Mathematical modeling and quantitative study of biological motility (in particular, of motility at microscopic scales) is producing new biophysical insight and is offering opportunities for new discoveries at the level of both fundamental science and technology. These range from the explanation of how complex behavior at the level of a single organism emerges from body architecture, to the understanding of collective phenomena in groups of organisms and tissues, and of how these forms of swarm intelligence can be controlled and harnessed in engineering applications, to the elucidation of processes of fundamental biological relevance at the cellular and sub-cellular level. In this paper, some of the most exciting new developments in the fields of locomotion of unicellular organisms, of soft adhesive locomotion across scales, of the study of pore translocation properties of knotted DNA, of the development of synthetic active solid sheets, of the mechanics of the unjamming transition in dense cell collectives, of the mechanics of cell sheet folding in volvocalean algae, and of the self-propulsion of topological defects in active matter are discussed. For each of these topics, we provide a brief state of the art, an example of recent achievements, and some directions for future research.

10aactive matter10aadhesive locomotion10acell motility10acell sheet folding10aknotted DNA10atopological defects10aunicellular swimmers10aunjamming transition1 aAgostinelli, Daniele1 aCerbino, Roberto1 aDel Alamo, Juan, C1 aDeSimone, Antonio1 aHöhn, Stephanie1 aMicheletti, Cristian1 aNoselli, Giovanni1 aSharon, Eran1 aYeomans, Julia uhttp://dx.doi.org/10.3934/mine.202001101292nas a2200145 4500008004100000245004900041210004900090300001200139490000700151520086800158100002901026700002101055700002401076856004601100 2019 eng d00aGround state energy of mixture of Bose gases0 aGround state energy of mixture of Bose gases a19500050 v313 aWe consider the asymptotic behavior of a system of multi-component trapped bosons, when the total particle number N becomes large. In the dilute regime, when the interaction potentials have the length scale of order O(N−1), we show that the leading order of the ground state energy is captured correctly by the Gross–Pitaevskii energy functional and that the many-body ground state fully condensates on the Gross–Pitaevskii minimizers. In the mean-field regime, when the interaction length scale is O(1), we are able to verify Bogoliubov’s approximation and obtain the second order expansion of the ground state energy. While such asymptotic results have several precursors in the literature on one-component condensates, the adaptation to the multi-component setting is non-trivial in various respects and the analysis will be presented in detail.

1 aMichelangeli, Alessandro1 aNam, Phan, Thanh1 aOlgiati, Alessandro uhttps://doi.org/10.1142/S0129055X1950005302026nas a2200205 4500008004100000022001400041245009500055210006900150300001100219520136500230653002001595653002401615653001701639653002101656100002501677700002701702700002201729700002201751856004701773 2019 eng d a0022-509600aNutations in growing plant shoots: The role of elastic deformations due to gravity loading0 aNutations in growing plant shoots The role of elastic deformatio a1037023 aThe effect of elastic deformations induced by gravity loading on the active circumnutation movements of growing plant shoots is investigated. We consider first a discrete model (a gravitropic spring-pendulum system) and then a continuous rod model which is analyzed both analytically (under the assumption of small deformations) and numerically (in the large deformation regime). We find that, for a choice of material parameters consistent with values reported in the available literature on plant shoots, rods of sufficient length may exhibit lateral oscillations of increasing amplitude, which eventually converge to limit cycles. This behavior strongly suggests the occurrence of a Hopf bifurcation, just as for the gravitropic spring-pendulum system, for which this result is rigorously established. At least in this restricted set of material parameters, our analysis supports a view of Darwin’s circumnutations as a biological analogue to structural systems exhibiting flutter instabilities, i.e., spontaneous oscillations away from equilibrium configurations driven by non-conservative loads. Here, in the context of nutation movements of growing plant shoots, the energy needed to sustain oscillations is continuously supplied to the system by the internal biochemical machinery presiding the capability of plants to maintain a vertical pose.

10aCircumnutations10aFlutter instability10aGravitropism10aHopf bifurcation1 aAgostinelli, Daniele1 aLucantonio, Alessandro1 aNoselli, Giovanni1 aDeSimone, Antonio uhttps://doi.org/10.1016/j.jmps.2019.10370201047nas a2200133 4500008004100000245007000041210006900111300001400180490000700194520062800201100002400829700002100853856003900874 2018 eng d00aAnalysis of a Dynamic Peeling Test with Speed-Dependent Toughness0 aAnalysis of a Dynamic Peeling Test with SpeedDependent Toughness a1206-12270 v783 aWe analyse a one-dimensional model of dynamic debonding for a thin film, where the local toughness of the glue between the film and the substrate also depends on the debonding speed. The wave equation on the debonded region is strongly coupled with Griffith's criterion for the evolution of the debonding front. We provide an existence and uniqueness result and find explicitly the solution in some concrete examples. We study the limit of solutions as inertia tends to zero, observing phases of unstable propagation, as well as time discontinuities, even though the toughness diverges at a limiting debonding speed.

1 aLazzaroni, Giuliano1 aNardini, Lorenzo uhttps://doi.org/10.1137/17M114735400579nas a2200145 4500008004100000245010500041210006900146300001600215490000700231100001500238700001600253700001700269700001800286856012900304 2018 eng d00aAn authenticated theoretical modeling of electrified fluid jet in core–shell nanofibers production0 aauthenticated theoretical modeling of electrified fluid jet in c a1791–18110 v471 aRafiei, S.1 aNoroozi, B.1 aHeltai, Luca1 aHaghi, A., K. uhttps://www.math.sissa.it/publication/authenticated-theoretical-modeling-electrified-fluid-jet-core%E2%80%93shell-nanofibers00945nas a2200109 4500008004100000245010200041210006900143520053000212100002100742700001800763856005400781 2018 en d00aExistence and uniqueness of dynamic evolutions for a one dimensional debonding model with damping0 aExistence and uniqueness of dynamic evolutions for a one dimensi3 aIn this paper we analyse a one-dimensional debonding model for a thin film peeled from a substrate when friction is taken into account. It is described by the weakly damped wave equation whose domain, the debonded region, grows according to a Griffth's criterion. Firstly we prove that the equation admits a unique solution when the evolution of the debonding front is assigned. Finally we provide an existence and uniqueness result for the coupled problem given by the wave equation together with Griffth's criterion.

1 aNardini, Lorenzo1 aRiva, Filippo uhttp://preprints.sissa.it/xmlui/handle/1963/3531900840nas a2200133 4500008004100000245007200041210006800113260001000181520040400191100001600595700002900611700001800640856004800658 2018 en d00aOn Krylov solutions to infinite-dimensional inverse linear problems0 aKrylov solutions to infinitedimensional inverse linear problems bSISSA3 aWe discuss, in the context of inverse linear problems in Hilbert space, the notion of the associated infinite-dimensional Krylov subspace and we produce necessary and sufficient conditions for the Krylov-solvability of the considered inverse problem. The presentation is based on theoretical results together with a series of model examples, and it is corroborated by specific numerical experiments.1 aCaruso, Noe1 aMichelangeli, Alessandro1 aNovati, Paolo uhttp://preprints.sissa.it/handle/1963/3532701671nas a2200205 4500008004100000022001400041245009100055210006900146300001100215490000800226520095800234653002501192653005401217653002501271653002901296100002501325700001901350700002501369856007101394 2018 eng d a0021-782400aMinimizing movements for mean curvature flow of droplets with prescribed contact angle0 aMinimizing movements for mean curvature flow of droplets with pr a1 - 580 v1173 aWe study the mean curvature motion of a droplet flowing by mean curvature on a horizontal hyperplane with a possibly nonconstant prescribed contact angle. Using the solutions constructed as a limit of an approximation algorithm of Almgren–Taylor–Wang and Luckhaus–Sturzenhecker, we show the existence of a weak evolution, and its compatibility with a distributional solution. We also prove various comparison results. Résumé Nous étudions le mouvement par courbure moyenne d'une goutte qui glisse par courbure moyenne sur un hyperplan horizontal avec un angle de contact prescrit éventuellement non constant. En utilisant les solutions construites comme limites d'un algorithme d'approximation dû à Almgren, Taylor et Wang et Luckhaus et Sturzenhecker, nous montrons l'existence d'une évolution faible, et sa compatibilité avec une solution au sens des distributions. Nous démontrons également plusieurs résultats de comparaison.

10aCapillary functional10aMean curvature flow with prescribed contact angle10aMinimizing movements10aSets of finite perimeter1 aBellettini, Giovanni1 aNovaga, Matteo1 aKholmatov, Shokhrukh uhttp://www.sciencedirect.com/science/article/pii/S002178241830082501019nas a2200157 4500008004100000022001400041245008700055210006900142260000800211300001400219490000700233520053000240100002400770700002100794856004600815 2018 eng d a1432-146700aOn the Quasistatic Limit of Dynamic Evolutions for a Peeling Test in Dimension One0 aQuasistatic Limit of Dynamic Evolutions for a Peeling Test in Di cFeb a269–3040 v283 aThe aim of this paper is to study the quasistatic limit of a one-dimensional model of dynamic debonding. We start from a dynamic problem that strongly couples the wave equation in a time-dependent domain with Griffith's criterion for the evolution of the domain. Passing to the limit as inertia tends to zero, we find that the limit evolution satisfies a stability condition; however, the activation rule in Griffith's (quasistatic) criterion does not hold in general, thus the limit evolution is not rate-independent.

1 aLazzaroni, Giuliano1 aNardini, Lorenzo uhttps://doi.org/10.1007/s00332-017-9407-000631nas a2200133 4500008004100000245015100041210006900192100002800261700002200289700001700311700002400328700002100352856012400373 2018 eng d00aA Reduced Basis approach for PDEs on parametrized geometries based on the Shifted Boundary Finite Element Method and application to fluid dynamics0 aReduced Basis approach for PDEs on parametrized geometries based1 aKaratzas, Efthymios, N.1 aStabile, Giovanni1 aNouveau, Leo1 aScovazzi, Guglielmo1 aRozza, Gianluigi uhttps://www.math.sissa.it/publication/reduced-basis-approach-pdes-parametrized-geometries-based-shifted-boundary-finite01137nas a2200133 4500008004100000245009100041210006900132260001000201520068100211100001600892700002900908700001800937856004800955 2018 en d00aTruncation and convergence issues for bounded linear inverse problems in Hilbert space0 aTruncation and convergence issues for bounded linear inverse pro bSISSA3 aWe present a general discussion of the main features and issues that (bounded) inverse linear problems in Hilbert space exhibit when the dimension of the space is infinite. This includes the set-up of a consistent notation for inverse problems that are genuinely infinite-dimensional, the analysis of the finite-dimensional truncations, a discussion of the mechanisms why the error or the residual generically fail to vanish in norm, and the identification of practically plausible sufficient conditions for such indicators to be small in some weaker sense. The presentation is based on theoretical results together with a series of model examples and numerical tests.1 aCaruso, Noe1 aMichelangeli, Alessandro1 aNovati, Paolo uhttp://preprints.sissa.it/handle/1963/3532600999nas a2200121 4500008004100000245009100041210006900132260001000201520057300211100002400784700002100808856004800829 2017 en d00aOn the 1D wave equation in time-dependent domains and the problem of debond initiation0 a1D wave equation in timedependent domains and the problem of deb bSISSA3 aMotivated by a debonding model for a thin film peeled from a substrate, we analyse the one-dimensional wave equation, in a time-dependent domain which is degenerate at the initial time. In the first part of the paper we prove existence for the wave equation when the evolution of the domain is given; in the second part of the paper, the evolution of the domain is unknown and is governed by an energy criterion coupled with the wave equation. Our existence result for such coupled problem is a contribution to the study of crack initiation in dynamic fracture.

1 aLazzaroni, Giuliano1 aNardini, Lorenzo uhttp://preprints.sissa.it/handle/1963/3530201160nas a2200205 4500008004100000022001400041245006400055210006400119300000900183490000700192520049200199653003500691653001800726653003600744653002900780100002500809700001900834700002500853856007600878 2017 eng d a1534-039200aMinimizers of anisotropic perimeters with cylindrical norms0 aMinimizers of anisotropic perimeters with cylindrical norms a14270 v163 aWe study various regularity properties of minimizers of the Φ–perimeter, where Φ is a norm. Under suitable assumptions on Φ and on the dimension of the ambient space, we prove that the boundary of a cartesian minimizer is locally a Lipschitz graph out of a closed singular set of small Hausdorff dimension. Moreover, we show the following anisotropic Bernstein-type result: any entire cartesian minimizer is the subgraph of a monotone function depending only on one variable.

10aanisotropic Bernstein problem;10aminimal cones10aNon parametric minimal surfaces10aSets of finite perimeter1 aBellettini, Giovanni1 aNovaga, Matteo1 aKholmatov, Shokhrukh uhttp://aimsciences.org//article/id/47054f15-00c7-40b7-9da1-4c0b1d0a103d00446nas a2200133 4500008004100000022001400041245009200055210006900147260000800216300001400224490000700238100002100245856004600266 2017 eng d a1572-922200aA Note on the Convergence of Singularly Perturbed Second Order Potential-Type Equations0 aNote on the Convergence of Singularly Perturbed Second Order Pot cJun a783–7970 v291 aNardini, Lorenzo uhttps://doi.org/10.1007/s10884-015-9461-y01239nas a2200169 4500008004100000022001400041245003900055210003900094260000800133300000700141490000900148520080000157100001900957700002500976700002401001856004401025 2017 eng d a1029-847900aReal topological string amplitudes0 aReal topological string amplitudes cMar a800 v20173 aWe discuss the physical superstring correlation functions in type I theory (or equivalently type II with orientifold) that compute real topological string amplitudes. We consider the correlator corresponding to holomorphic derivative of the real topological amplitude $\mathcal{G_\chi}$, at fixed worldsheet Euler characteristic $\chi$. This corresponds in the low-energy effective action to $\mathcal{N}=2$ Weyl multiplet, appropriately reduced to the orientifold invariant part, and raised to the power $g'= −\chi+ 1$. We show that the physical string correlator gives precisely the holomorphic derivative of topological amplitude. Finally, we apply this method to the standard closed oriented case as well, and prove a similar statement for the topological amplitude $\mathcal{F}_g$.

1 aNarain, K., S.1 aPiazzalunga, Nicolò1 aTanzini, Alessandro uhttps://doi.org/10.1007/JHEP03(2017)08000453nas a2200133 4500008004100000245009600041210006900137260000700206300001100213100001900224700002100243700001800264856003700282 2017 eng d00aSymplectic geometry of the moduli space of projective structures in homological coordinates0 aSymplectic geometry of the moduli space of projective structures c06 a1–561 aBertola, Marco1 aKorotkin, Dmitry1 aNorton, Chaya uhttps://arxiv.org/abs/1506.0791801120nas a2200229 4500008004100000022001400041245008700055210006900142300001600211490000800227520034000235653002200575653003200597653002100629653002500650653003400675653004400709100002100753700002400774700002100798856007100819 2016 eng d a0022-039600aExistence and uniqueness of dynamic evolutions for a peeling test in dimension one0 aExistence and uniqueness of dynamic evolutions for a peeling tes a4897 - 49230 v2613 aIn this paper we present a one-dimensional model of a dynamic peeling test for a thin film, where the wave equation is coupled with a Griffith criterion for the propagation of the debonding front. Our main results provide existence and uniqueness for the solution to this coupled problem under different assumptions on the data.

10aDynamic debonding10aDynamic energy release rate10aDynamic fracture10aGriffith's criterion10aMaximum dissipation principle10aWave equation in time-dependent domains1 aDal Maso, Gianni1 aLazzaroni, Giuliano1 aNardini, Lorenzo uhttp://www.sciencedirect.com/science/article/pii/S002203961630177201765nas a2200217 4500008004100000022001400041245005300055210005300108300001400161490000700175520110000182653002201282653002501304653002801329653003001357653002701387100002201414700001801436700002201454856007101476 2015 eng d a0022-509600aLiquid crystal elastomer strips as soft crawlers0 aLiquid crystal elastomer strips as soft crawlers a254 - 2720 v843 aIn this paper, we speculate on a possible application of Liquid Crystal Elastomers to the field of soft robotics. In particular, we study a concept for limbless locomotion that is amenable to miniaturisation. For this purpose, we formulate and solve the evolution equations for a strip of nematic elastomer, subject to directional frictional interactions with a flat solid substrate, and cyclically actuated by a spatially uniform, time-periodic stimulus (e.g., temperature change). The presence of frictional forces that are sensitive to the direction of sliding transforms reciprocal, ‘breathing-like’ deformations into directed forward motion. We derive formulas quantifying this motion in the case of distributed friction, by solving a differential inclusion for the displacement field. The simpler case of concentrated frictional interactions at the two ends of the strip is also solved, in order to provide a benchmark to compare the continuously distributed case with a finite-dimensional benchmark. We also provide explicit formulas for the axial force along the crawler body.

10aCrawling motility10aDirectional surfaces10aFrictional interactions10aLiquid crystal elastomers10aSoft biomimetic robots1 aDeSimone, Antonio1 aGidoni, Paolo1 aNoselli, Giovanni uhttp://www.sciencedirect.com/science/article/pii/S002250961530043001235nas a2200145 4500008004100000245010300041210006900144300001400213490000700227520066400234100002000898700002000918700002100938856013000959 2015 eng d00aReduced basis approximation of parametrized optimal flow control problems for the Stokes equations0 aReduced basis approximation of parametrized optimal flow control a319–3360 v693 aThis paper extends the reduced basis method for the solution of parametrized optimal control problems presented in Negri et al. (2013) to the case of noncoercive (elliptic) equations, such as the Stokes equations. We discuss both the theoretical properties-with particular emphasis on the stability of the resulting double nested saddle-point problems and on aggregated error estimates-and the computational aspects of the method. Then, we apply it to solve a benchmark vorticity minimization problem for a parametrized bluff body immersed in a two or a three-dimensional flow through boundary control, demonstrating the effectivity of the methodology.

1 aNegri, Federico1 aManzoni, Andrea1 aRozza, Gianluigi uhttps://www.math.sissa.it/publication/reduced-basis-approximation-parametrized-optimal-flow-control-problems-stokes-equations01081nas a2200145 4500008004100000245007400041210006900115260003100184520057600215100002700791700002100818700002300839700002200862856005100884 2014 en d00aBuckling dynamics of a solvent-stimulated stretched elastomeric sheet0 aBuckling dynamics of a solventstimulated stretched elastomeric s bRoyal Society of Chemistry3 aWhen stretched uniaxially, a thin elastic sheet may exhibit buckling. The occurrence of buckling depends on the geometrical properties of the sheet and the magnitude of the applied strain. Here we show that an elastomeric sheet initially stable under uniaxial stretching can destabilize when exposed to a solvent that swells the elastomer. We demonstrate experimentally and computationally that the features of the buckling pattern depend on the magnitude of stretching, and this observation offers a new way for controlling the shape of a swollen homogeneous thin sheet.1 aLucantonio, Alessandro1 aRoché, Matthieu1 aNardinocchi, Paola1 aStone, Howard, A. uhttp://urania.sissa.it/xmlui/handle/1963/3496701733nas a2200217 4500008004100000022001400041245003700055210003700092300001200129490000700141520111900148653002901267653001901296653002201315653002501337653002001362100001801382700002201400700002201422856007101444 2014 eng d a0020-746200aCrawling on directional surfaces0 aCrawling on directional surfaces a65 - 730 v613 aIn this paper we study crawling locomotion based on directional frictional interactions, namely, frictional forces that are sensitive to the sign of the sliding velocity. Surface interactions of this type are common in biology, where they arise from the presence of inclined hairs or scales at the crawler/substrate interface, leading to low resistance when sliding ‘along the grain’, and high resistance when sliding ‘against the grain’. This asymmetry can be exploited for locomotion, in a way analogous to what is done in cross-country skiing (classic style, diagonal stride). We focus on a model system, namely, a continuous one-dimensional crawler and provide a detailed study of the motion resulting from several strategies of shape change. In particular, we provide explicit formulae for the displacements attainable with reciprocal extensions and contractions (breathing), or through the propagation of extension or contraction waves. We believe that our results will prove particularly helpful for the study of biological crawling motility and for the design of bio-mimetic crawling robots.

10aBio-mimetic micro-robots10aCell migration10aCrawling motility10aDirectional surfaces10aSelf-propulsion1 aGidoni, Paolo1 aNoselli, Giovanni1 aDeSimone, Antonio uhttp://www.sciencedirect.com/science/article/pii/S002074621400021301213nas a2200145 4500008004100000245011200041210006900153260001300222520069800235653001900933100002200952700002000974700002200994856005101016 2014 en d00aDiscrete one-dimensional crawlers on viscous substrates: achievable net displacements and their energy cost0 aDiscrete onedimensional crawlers on viscous substrates achievabl bElsevier3 aWe study model one-dimensional crawlers, namely, model mechanical systems that can achieve self-propulsion by controlled shape changes of their body (extension or contraction of portions of the body), thanks to frictional interactions with a rigid substrate. We evaluate the achievable net displacement and the related energetic cost for self-propulsion by discrete crawlers (i.e., whose body is made of a discrete number of contractile or extensile segments) moving on substrates with either a Newtonian (linear) or a Bingham-type (stick-slip) rheology. Our analysis is aimed at constructing the basic building blocks towards an integrative, multi-scale description of crawling cell motility.10aCell migration1 aNoselli, Giovanni1 aTatone, Amabile1 aDeSimone, Antonio uhttp://urania.sissa.it/xmlui/handle/1963/3444901083nas a2200121 4500008004100000245012700041210006900168260002900237520052100266100002200787700002200809856013000831 2014 en d00aA robotic crawler exploiting directional frictional interactions: experiments, numerics, and derivation of a reduced model0 arobotic crawler exploiting directional frictional interactions e bRoyal Society Publishing3 aWe present experimental and numerical results for a model crawler which is able to extract net positional changes from reciprocal shape changes, i.e. ‘breathing-like’ deformations, thanks to directional, frictional interactions with a textured solid substrate, mediated by flexible inclined feet. We also present a simple reduced model that captures the essential features of the kinematics and energetics of the gait, and compare its predictions with the results from experiments and from numerical simulations.1 aNoselli, Giovanni1 aDeSimone, Antonio uhttps://www.math.sissa.it/publication/robotic-crawler-exploiting-directional-frictional-interactions-experiments-numerics-and01169nas a2200133 4500008004100000245007700041210006900118260003400187520069100221100002700912700002300939700002200962856005100984 2014 en d00aSwelling dynamics of a thin elastomeric sheet under uniaxial pre-stretch0 aSwelling dynamics of a thin elastomeric sheet under uniaxial pre bAmerican Institute of Physics3 aIt has been demonstrated experimentally that pre-stretch affects the swelling of an elastomeric membrane when it is exposed to a solvent. We study theoretically the one-dimensional swelling of a pre-stretched thin elastomeric sheet, bonded to an impermeable rigid substrate, to quantify the influence of pre-stretch. We show that the solvent uptake increases when pre-stretch increases, both at equilibrium and during the swelling transient, where it exhibits two different scaling regimes. The coupling between the solvent uptake and pre-stretch may be practically exploited to design soft actuators where the swelling-induced deformations can be controlled by varying the pre-stretch.1 aLucantonio, Alessandro1 aNardinocchi, Paola1 aStone, Howard, A. uhttp://urania.sissa.it/xmlui/handle/1963/3511301394nas a2200133 4500008004100000245006500041210006400106260002800170520094000198100002701138700002301165700002101188856005101209 2014 en d00aSwelling-induced and controlled curving in layered gel beams0 aSwellinginduced and controlled curving in layered gel beams bRoyal Society of London3 aWe describe swelling-driven curving in originally straight and non-homogeneous beams. We present and verify a structural model of swollen beams, based on a new point of view adopted to describe swelling-induced deformation processes in bilayered gel beams, that is based on the split of the swelling-induced deformation of the beam at equilibrium into two components, both depending on the elastic properties of the gel. The method allows us to: (i) determine beam stretching and curving, once assigned the characteristics of the solvent bath and of the non-homogeneous beam, and (ii) estimate the characteristics of non-homogeneous flat gel beams in such a way as to obtain, under free-swelling conditions, three-dimensional shapes. The study was pursued by means of analytical, semi-analytical and numerical tools; excellent agreement of the outcomes of the different techniques was found, thus confirming the strength of the method.1 aLucantonio, Alessandro1 aNardinocchi, Paola1 aPezzulla, Matteo uhttp://urania.sissa.it/xmlui/handle/1963/3498701071nas a2200145 4500008004100000245006700041210006600108260001300174520054900187100002200736700002400758700002200782700002000804856010100824 2013 en d00aCrawlers in viscous environments: linear vs nonlinear rheology0 aCrawlers in viscous environments linear vs nonlinear rheology bElsevier3 aWe study model self-propelled crawlers which derive their propulsive capabilities from the tangential resistance to motion offered by the environment. Two types of relationships between tangential forces and slip velocities are considered: a linear, Newtonian one and a nonlinear one of Bingham-type. Different behaviors result from the two different rheologies. These differences and their implications in terms of motility performance are discussed. Our aim is to develop new tools and insight for future studies of cell motility by crawling.1 aDeSimone, Antonio1 aGuarnieri, Federica1 aNoselli, Giovanni1 aTatone, Amabile uhttps://www.math.sissa.it/publication/crawlers-viscous-environments-linear-vs-nonlinear-rheology01676nas a2200145 4500008004100000245009400041210006900135260001000204520112400214653008201338100002001420700002501440700002901465856003601494 2013 en d00aMinimal partitions and image classification using a gradient-free perimeter approximation0 aMinimal partitions and image classification using a gradientfree bSISSA3 aIn this paper a new mathematically-founded method for the optimal partitioning of domains, with applications to the classification of greyscale and color images, is proposed. Since optimal partition problems are in general ill-posed, some regularization strategy is required. Here we regularize by a non-standard approximation of the total interface length, which does not involve the gradient of approximate characteristic functions, in contrast to the classical Modica-Mortola approximation. Instead, it involves a system of uncoupled linear partial differential equations and nevertheless shows $\Gamma$-convergence properties in appropriate function spaces. This approach leads to an alternating algorithm that ensures a decrease of the objective function at each iteration, and which always provides a partition, even during the iterations. The efficiency of this algorithm is illustrated by various numerical examples. Among them we consider binary and multilabel minimal partition problems including supervised or automatic image classification, inpainting, texture pattern identification and deblurring.10aImage classification, deblurring, optimal partitions, perimeter approximation1 aAmstutz, Samuel1 aVan Goethem, Nicolas1 aNovotny, Antonio, André uhttp://hdl.handle.net/1963/697601701nas a2200157 4500008004100000245007600041210006900117300001800186490000700204520113900211100002001350700002101370700002001391700002201411856011001433 2013 eng d00aReduced basis method for parametrized elliptic optimal control problems0 aReduced basis method for parametrized elliptic optimal control p aA2316–A23400 v353 aWe propose a suitable model reduction paradigm-the certified reduced basis method (RB)-for the rapid and reliable solution of parametrized optimal control problems governed by partial differential equations. In particular, we develop the methodology for parametrized quadratic optimization problems with elliptic equations as a constraint and infinite-dimensional control variable. First, we recast the optimal control problem in the framework of saddle-point problems in order to take advantage of the already developed RB theory for Stokes-type problems. Then, the usual ingredients of the RB methodology are called into play: a Galerkin projection onto a low-dimensional space of basis functions properly selected by an adaptive procedure; an affine parametric dependence enabling one to perform competitive offline-online splitting in the computational procedure; and an efficient and rigorous a posteriori error estimate on the state, control, and adjoint variables as well as on the cost functional. Finally, we address some numerical tests that confirm our theoretical results and show the efficiency of the proposed technique.1 aNegri, Federico1 aRozza, Gianluigi1 aManzoni, Andrea1 aQuarteroni, Alfio uhttps://www.math.sissa.it/publication/reduced-basis-method-parametrized-elliptic-optimal-control-problems01218nas a2200121 4500008004100000245008200041210006900123520080800192100002201000700002301022700001501045856003601060 2013 en d00aStabilization of Stochastic Quantum Dynamics via Open and Closed Loop Control0 aStabilization of Stochastic Quantum Dynamics via Open and Closed3 aIn this paper, we investigate parametrization-free solutions of the problem of quantum pure state preparation and subspace stabilization by means of Hamiltonian control, continuous measurement, and quantum feedback, in the presence of a Markovian environment. In particular, we show that whenever suitable dissipative effects are induced either by the unmonitored environment, or by non-Hermitian measurements, there is no need for feedback, as open-loop time-invariant control is sufficient to achieve stabilization of the target set in probability. Constructive necessary and sufficient conditions on the form of the control Hamiltonian can be provided in this case. When time-invariant control is not sufficient, state stabilization can be attained by the addition of filtering-based feedback control1 aAltafini, Claudio1 aTicozzi, Francesco1 aNishio, K. uhttp://hdl.handle.net/1963/650301651nas a2200133 4500008004100000245008400041210006900125520120500194653002101399100002101420700002001441700002001461856003601481 2012 en d00aReduction strategies for PDE-constrained oprimization problems in Haemodynamics0 aReduction strategies for PDEconstrained oprimization problems in3 aSolving optimal control problems for many different scenarios obtained by varying a set of parameters in the state system is a computationally extensive task. In this paper we present a new reduced framework for the formulation, the analysis and the numerical solution of parametrized PDE-constrained optimization problems. This framework is based on a suitable saddle-point formulation of the optimal control problem and exploits the reduced basis method for the rapid and reliable solution of parametrized PDEs, leading to a relevant computational reduction with respect to traditional discretization techniques such as the finite element method. This allows a very efficient evaluation of state solutions and cost functionals, leading to an effective solution of repeated optimal control problems, even on domains of variable shape, for which a further (geometrical) reduction is pursued, relying on flexible shape parametrization techniques. This setting is applied to the solution of two problems arising from haemodynamics, dealing with both data reconstruction and data assimilation over domains of variable shape,\\r\\nwhich can be recast in a common PDE-constrained optimization formulation.10ainverse problems1 aRozza, Gianluigi1 aManzoni, Andrea1 aNegri, Federico uhttp://hdl.handle.net/1963/633801511nas a2200145 4500008004100000245007100041210006900112260001000181520099600191653006801187100002001255700002901275700002501304856003601329 2012 en d00aTopological sensitivity analysis for high order elliptic operators0 aTopological sensitivity analysis for high order elliptic operato bSISSA3 aThe topological derivative is defined as the first term of the asymptotic expansion of a given shape functional with respect to a small parameter that measures the size of a singular domain perturbation. It has applications in many different fields such as shape and topology optimization, inverse problems, image processing and mechanical modeling including synthesis and/or optimal design of microstructures, fracture mechanics sensitivity analysis and damage evolution modeling. The topological derivative has been fully developed for a wide range of second order differential operators. In this paper we deal with the topological asymptotic expansion of a class of shape functionals associated with elliptic differential operators of order 2m, m>=1. The general structure of the polarization tensor is derived and the concept of degenerate polarization tensor is introduced. We provide full mathematical justifications for the derived formulas, including precise estimates of remainders.10aTopological derivative, Elliptic operators, Polarization tensor1 aAmstutz, Samuel1 aNovotny, Antonio, André1 aVan Goethem, Nicolas uhttp://hdl.handle.net/1963/634300645nas a2200121 4500008004300000245011200043210006900155520019600224100002300420700002200443700002200465856003600487 2007 en_Ud 00aAsymptotic behaviour of smooth solutions for partially dissipative hyperbolic systems with a convex entropy0 aAsymptotic behaviour of smooth solutions for partially dissipati3 aWe study the asymptotic time behavior of global smooth solutions to general entropy dissipative hyperbolic systems of balance law in m space dimensions, under the Shizuta-Kawashima condition.1 aBianchini, Stefano1 aHanouzet, Bernard1 aNatalini, Roberto uhttp://hdl.handle.net/1963/178000420nas a2200121 4500008004100000245006400041210006300105260003700168100002200205700001700227700001800244856003600262 2007 en d00aBoundary-clustered interfaces for the Allen–Cahn equation0 aBoundaryclustered interfaces for the Allen–Cahn equation bMathematical Sciences Publishers1 aMalchiodi, Andrea1 aNi, Wei-Ming1 aWei, Juncheng uhttp://hdl.handle.net/1963/508900729nas a2200121 4500008004300000245002700043210002700070520041600097100002200513700001800535700001800553856003600571 2007 en_Ud 00aSmooth toric DM stacks0 aSmooth toric DM stacks3 aWe give a new definition of smooth toric DM stacks in the same spirit of toric varieties. We show that our definition is equivalent to the one of Borisov, Chen and Smith in terms of stacky fans. In particular, we give a geometric interpretation of the combinatorial data contained in a stacky fan. We also give a bottom up classification in terms of simplicial toric varieties and fiber products of root stacks.1 aFantechi, Barbara1 aMann, Etienne1 aNironi, Fabio uhttp://hdl.handle.net/1963/212000914nas a2200109 4500008004300000245006600043210006600109520054400175100002200719700002700741856003600768 2007 en_Ud 00aSome existence results for the Toda system on closed surfaces0 aSome existence results for the Toda system on closed surfaces3 aGiven a compact closed surface $\\\\Sig$, we consider the {\\\\em generalized Toda} system of equations on $\\\\Sig$: $- \\\\D u_i = \\\\sum_{j=1}^2 \\\\rho_j a_{ij} \\\\left( \\\\frac{h_j e^{u_j}}{\\\\int_\\\\Sig h_j e^{u_j} dV_g} - 1 \\\\right)$ for $i = 1, 2$, where $\\\\rho_1, \\\\rho_2$ are real parameters and $h_1, h_2$ are smooth positive functions. Exploiting the variational structure of the problem and using a new minimax scheme we prove existence of solutions for generic values of $\\\\rho_1$ and for $\\\\rho_2 < 4 \\\\pi$.1 aMalchiodi, Andrea1 aNdiaye, Cheikh Birahim uhttp://hdl.handle.net/1963/177500378nas a2200109 4500008004300000245006600043210006400109100001700173700001900190700002300209856003600232 2006 en_Ud 00aClassification of stable time-optimal controls on 2-manifolds0 aClassification of stable timeoptimal controls on 2manifolds1 aBoscain, Ugo1 aNikolaev, Igor1 aPiccoli, Benedetto uhttp://hdl.handle.net/1963/219602436nas a2200169 4500008004100000245007600041210006900117260007200186520184400258100002002102700002202122700001802144700002502162700001902187700002402206856003602230 2006 en d00aExperimental and modeling studies of desensitization of P2X3 receptors.0 aExperimental and modeling studies of desensitization of P2X3 rec bthe American Society for Pharmacology and Experimental Therapeutics3 aThe function of ATP-activated P2X3 receptors involved in pain sensation is modulated by desensitization, a phenomenon poorly understood. The present study used patch-clamp recording from cultured rat or mouse sensory neurons and kinetic modeling to clarify the properties of P2X3 receptor desensitization. Two types of desensitization were observed, a fast process (t1/2 = 50 ms; 10 microM ATP) following the inward current evoked by micromolar agonist concentrations, and a slow process (t1/2 = 35 s; 10 nM ATP) that inhibited receptors without activating them. We termed the latter high-affinity desensitization (HAD). Recovery from fast desensitization or HAD was slow and agonist-dependent. When comparing several agonists, there was analogous ranking order for agonist potency, rate of desensitization and HAD effectiveness, with 2-methylthioadenosine triphosphate the strongest and beta,gamma-methylene-ATP the weakest. HAD was less developed with recombinant (ATP IC50 = 390 nM) than native P2X3 receptors (IC50 = 2.3 nM). HAD could also be induced by nanomolar ATP when receptors seemed to be nondesensitized, indicating that resting receptors could express high-affinity binding sites. Desensitization properties were well accounted for by a cyclic model in which receptors could be desensitized from either open or closed states. Recovery was assumed to be a multistate process with distinct kinetics dependent on the agonist-dependent dissociation rate from desensitized receptors. Thus, the combination of agonist-specific mechanisms such as desensitization onset, HAD, and resensitization could shape responsiveness of sensory neurons to P2X3 receptor agonists. By using subthreshold concentrations of an HAD-potent agonist, it might be possible to generate sustained inhibition of P2X3 receptors for controlling chronic pain.1 aSokolova, Elena1 aSkorinkin, Andrei1 aMoiseev, Igor1 aAgrachev, Andrei, A.1 aNistri, Andrea1 aGiniatullin, Rashid uhttp://hdl.handle.net/1963/497400421nas a2200121 4500008004300000245008100043210006900124260001300193100002200206700001700228700001800245856003600263 2005 en_Ud 00aMultiple clustered layer solutions for semilinear Neumann problems on a ball0 aMultiple clustered layer solutions for semilinear Neumann proble bElsevier1 aMalchiodi, Andrea1 aNi, Wei-Ming1 aWei, Juncheng uhttp://hdl.handle.net/1963/353200490nas a2200121 4500008004100000245011600041210006900157260004300226100002400269700002200293700001700315856003600332 2004 en d00aSingularity perturbed elliptic equations with symmetry: existence of solutions concetrating on spheres, Part II0 aSingularity perturbed elliptic equations with symmetry existence bIndiana University Mathematics Journal1 aAmbrosetti, Antonio1 aMalchiodi, Andrea1 aNi, Wei-Ming uhttp://hdl.handle.net/1963/166300803nas a2200109 4500008004100000245008400041210006900125260001800194520042700212100001800639856003600657 2003 en d00aA finite element approximation of the Griffith\\\'s model in fracture mechanics0 afinite element approximation of the Griffiths model in fracture bSISSA Library3 aThe Griffith model for the mechanics of fractures in brittle materials is consider in the weak formulation of SBD spaces. We suggest an approximation, in the sense of Gamma-convergence, by a sequence of discrete functionals defined on finite elements spaces over structured and adaptive triangulations. The quasi-static evolution for boundary value problems is also taken into account and some numerical results are shown.1 aNegri, Matteo uhttp://hdl.handle.net/1963/154800459nas a2200121 4500008004100000245011500041210006900156260001300225100002400238700002200262700001700284856003600301 2003 en d00aSingularly perturbed elliptic equations with symmetry: existence of solutions concentrating on spheres, Part I0 aSingularly perturbed elliptic equations with symmetry existence bSpringer1 aAmbrosetti, Antonio1 aMalchiodi, Andrea1 aNi, Wei-Ming uhttp://hdl.handle.net/1963/163300398nas a2200121 4500008004300000245006200043210006100105260001300166100002100179700001800200700002200218856003600240 2002 en_Ud 00aLinearized elasticity as gamma-limit of finite elasticity0 aLinearized elasticity as gammalimit of finite elasticity bSpringer1 aDal Maso, Gianni1 aNegri, Matteo1 aPercivale, Danilo uhttp://hdl.handle.net/1963/305200585nas a2200133 4500008004100000245008200041210006900123260001800192520014200210100002400352700002200376700001700398856003600415 2002 en d00aSolutions concentrating on spheres to symmetric singularly perturbed problems0 aSolutions concentrating on spheres to symmetric singularly pertu bSISSA Library3 aWe discuss some existence results concerning problems (NLS) and (N), proving the existence of radial solutions concentrating on a sphere.1 aAmbrosetti, Antonio1 aMalchiodi, Andrea1 aNi, Wei-Ming uhttp://hdl.handle.net/1963/159400362nas a2200121 4500008004100000245004000041210003900081260001800120100002100138700001900159700002600178856003600204 2001 en d00aDieletric breakdown: optimal bounds0 aDieletric breakdown optimal bounds bSISSA Library1 aGarroni, Adriana1 aNesi, Vincenzo1 aPonsiglione, Marcello uhttp://hdl.handle.net/1963/156900408nas a2200109 4500008004100000245009600041210006900137260001000206653002800216100001800244856003600262 2001 en d00aNumerical Methods for Free-Discontinuity Problems Based on Approximations by Γ-Convergence0 aNumerical Methods for FreeDiscontinuity Problems Based on Approx bSISSA10aMumford-Shah functional1 aNegri, Matteo uhttp://hdl.handle.net/1963/539900360nas a2200109 4500008004100000245005800041210005700099260001800156100001800174700002200192856003600214 2001 en d00aNumerical minimization of the Mumford-Shah functional0 aNumerical minimization of the MumfordShah functional bSISSA Library1 aNegri, Matteo1 aPaolini, Maurizio uhttp://hdl.handle.net/1963/146100595nas a2200109 4500008004100000245010900041210006900150260002300219520018900242100001800431856003600449 1999 en d00aThe anisotropy introduced by the mesh in the finite element approximation of the Mumford-Shah functional0 aanisotropy introduced by the mesh in the finite element approxim bTaylor and Francis3 aWe compute explicitly the anisotropy effect in the H1 term, generated in the approximation of the Mumford-Shah functional by finite element spaces defined on structured triangulations.1 aNegri, Matteo uhttp://hdl.handle.net/1963/127600455nas a2200133 4500008004100000245007400041210006900115260001000184100002100194700002300215700002300238700002400261856003600285 1998 en d00aLimits of variational problems for Dirichlet forms in varying domains0 aLimits of variational problems for Dirichlet forms in varying do bSISSA1 aDal Maso, Gianni1 aDe Cicco, Virginia1 aNotarantonio, Lino1 aTchou, Nicoletta A. uhttp://hdl.handle.net/1963/644001654nas a2200121 4500008004300000245006200043210006000105260001300165520127600178100002401454700001801478856003601496 1992 en_Ud 00aTopological "observables" in semiclassical field theories0 aTopological observables in semiclassical field theories bElsevier3 aWe give a geometrical set up for the semiclassical approximation to euclidean field theories having families of minima (instantons) parametrized by suitable moduli spaces ${\mathcal{M}}$. The standard examples are of course Yang-Mills theory and non-linear $\sigma$-models. The relevant space here is a family of measure spaces $\tilde{\mathcal{N}} \rightarrow \mathcal{M}$, with standard fibre a distribution space, given by a suitable extension of the normal bundle to $\mathcal{M}$ in the space of smooth fields. Over $\tilde{\mathcal{N}}$ there is a probability measure $d\mu$ given by the twisted product of the (normalized) volume element on $\mathcal{M}$ and the family of gaussian measures with covariance given by the tree propagator $C_\phi$ in the background of an instanton $\phi \in \mathcal{M}$. The space of "observables", i.e. measurable functions on ($\tilde{\mathcal{N}},\, d\mu$), is studied and it is shown to contain a topological sector, corresponding to the intersection theory on $\mathcal{M}$. The expectation value of these topological "observables" does not depend on the covariance; it is therefore exact at all orders in perturbation theory and can moreover be computed in the topological regime by setting the covariance to zero.

1 aNolasco, Margherita1 aReina, Cesare uhttp://hdl.handle.net/1963/3541