00704nas a2200181   4500008004100000245009900041210006900140300001400209490000700223100001700230700002000247700002000267700002200287700002100309700002000330700002200350856015000372       2017                        eng d00aNumerical modeling of hemodynamics scenarios of patient-specific coronary artery bypass grafts0 aNumerical modeling of hemodynamics scenarios of patientspecific   a1373-13990 v161 aBallarin, F.1 aFaggiano, Elena1 aManzoni, Andrea1 aQuarteroni, Alfio1 aRozza, Gianluigi1 aIppolito, Sonia1 aScrofani, Roberto  uhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85015065851&doi=10.1007%2fs10237-017-0893-7&partnerID=40&md5=c388f20bd5de14187bad9ed7d9affbd001710nas a2200193   4500008004100000245011900041210006900160260001400229520106200243100001701305700002001322700002001342700002101362700002201383700002001405700002201425700001801447856005101465       2016                        en  d00aA fast virtual surgery platform for many scenarios haemodynamics of patient-specific coronary artery bypass grafts0 afast virtual surgery platform for many scenarios haemodynamics o  bSubmitted3 aA fast computational framework is devised to the study of
several configurations of patient-specific coronary artery bypass
grafts. This is especially useful to perform a sensitivity
analysis of the haemodynamics for different flow conditions
occurring in native coronary arteries and bypass grafts, the
investigation of the progression of the coronary artery disease and the choice of the most appropriate surgical procedure.
A complete pipeline, from the acquisition of patientspecific
medical images to fast parametrized computational
simulations, is proposed. Complex surgical configurations
employed in the clinical practice, such as Y-grafts and sequential
grafts, are studied. A virtual surgery platform based
on model reduction of unsteady Navier Stokes equations for
blood dynamics is proposed to carry out sensitivity analyses
in a very rapid and reliable way. A specialized geometrical
parametrization is employed to compare the effect of stenosis
and anastomosis variation on the outcome of the surgery
in several relevant cases.1 aBallarin, F.1 aFaggiano, Elena1 aManzoni, Andrea1 aRozza, Gianluigi1 aQuarteroni, Alfio1 aIppolito, Sonia1 aScrofani, Roberto1 aAntona, Carlo  uhttp://urania.sissa.it/xmlui/handle/1963/3524001813nas a2200169   4500008004100000245015600041210006900197520118400266100001701450700002001467700002001487700002001507700002201527700002101549700002201570856005101592       2015                        en  d00aFast simulations of patient-specific haemodynamics of coronary artery bypass grafts based on a POD-Galerkin method and a vascular shape parametrization0 aFast simulations of patientspecific haemodynamics of coronary ar3 aIn this work a reduced-order computational framework for the study of haemodynamics
in three-dimensional patient-specific configurations of coronary artery bypass grafts
dealing with a wide range of scenarios is proposed. We combine several efficient algorithms to face at the same time both the geometrical complexity involved in the description of the vascular network and the huge computational cost entailed by time dependent patient-specific flow simulations. Medical imaging procedures allow to reconstruct patient-specific configurations from clinical data. A centerlines-based parametrization is proposed to efficiently handle geometrical variations. POD–Galerkin reduced-order models are employed to cut down large computational costs. This computational framework allows to characterize blood flows for different physical and geometrical variations relevant in the clinical practice, such as stenosis factors and anastomosis variations, in a rapid and reliable way. Several numerical results are
discussed, highlighting the computational performance of the proposed framework, as well as its capability to perform sensitivity analysis studies, so far out of reach.1 aBallarin, F.1 aFaggiano, Elena1 aIppolito, Sonia1 aManzoni, Andrea1 aQuarteroni, Alfio1 aRozza, Gianluigi1 aScrofani, Roberto  uhttp://urania.sissa.it/xmlui/handle/1963/34623