01813nas a2200205   4500008004100000245005400041210005400095260001400149300000700163520117300170100002601343700001901369700002001388700002101408700002201429700002101451700002601472700002501498856008401523       2018                        eng d00aComputational methods in cardiovascular mechanics0 aComputational methods in cardiovascular mechanics  bCRC Press  a543 a<p>The introduction of computational models in cardiovascular sciences has been progressively bringing new and unique tools for the investigation of the physiopathology. Together with the dramatic improvement of imaging and measuring devices on one side, and of computational architectures on the other one, mathematical and numerical models have provided a new, clearly noninvasive, approach for understanding not only basic mechanisms but also patient-specific conditions, and for supporting the design and the development of new therapeutic options. The terminology in silico is, nowadays, commonly accepted for indicating this new source of knowledge added to traditional in vitro and in vivo investigations. The advantages of in silico methodologies are basically the low cost in terms of infrastructures and facilities, the reduced invasiveness and, in general, the intrinsic predictive capabilities based on the use of mathematical models. The disadvantages are generally identified in the distance between the real cases and their virtual counterpart required by the conceptual modeling that can be detrimental for the reliability of numerical simulations.</p>1 aAuricchio, Ferdinando1 aConti, Michele1 aLefieux, Adrian1 aMorganti, Simone1 aReali, Alessandro1 aRozza, Gianluigi1 aVeneziani, Alessandro1 aLabrosse, Michel, F.  uhttps://www.taylorfrancis.com/books/e/9781315280288/chapters/10.1201%2Fb21917-5