01565nas a2200169 4500008004100000245010100041210006900142260001000211520092400221100002201145700002401167700002201191700001701213700001901230700002201249856012401271 2013 en d00aCommon dynamical features of sensory adaptation in photoreceptors and olfactory sensory neurons.0 aCommon dynamical features of sensory adaptation in photoreceptor bSISSA3 a
Sensory systems adapt, i.e., they adjust their sensitivity to external stimuli according to the ambient level. In this paper we show that single cell electrophysiological responses of vertebrate olfactory receptors and of photoreceptors to different input protocols exhibit several common features related to adaptation, and that these features can be used to investigate the dynamical structure of the feedback regulation responsible for the adaptation. In particular, we point out that two different forms of adaptation can be observed, in response to steps and to pairs of pulses. These two forms of adaptation appear to be in a dynamical trade-off: the more adaptation to a step is close to perfect, the slower is the recovery in adaptation to pulse pairs and viceversa. Neither of the two forms is explained by the dynamical models currently used to describe adaptation, such as the integral feedback model.
1 aDe Palo, Giovanna1 aFacchetti, Giuseppe1 aMazzolini, Monica1 aMenini, Anna1 aTorre, Vincent1 aAltafini, Claudio uhttps://www.math.sissa.it/publication/common-dynamical-features-sensory-adaptation-photoreceptors-and-olfactory-sensory01693nas a2200157 4500008004100000245008400041210006900125260003400194520117300228100002201401700002001423700001701443700001701460700002201477856003601499 2012 en d00aA dynamical feedback model for adaptation in the olfactory transduction pathway0 adynamical feedback model for adaptation in the olfactory transdu bBiophysical Society, Elsevier3 aOlfactory transduction exhibits two distinct types of adaptation, which we denote multipulse and step adaptation. In terms of measured transduction current, multipulse adaptation appears as a decrease in the amplitude of the second of two consecutive responses when the olfactory neuron is stimulated with two brief pulses. Step adaptation occurs in response to a sustained steplike stimulation and is characterized by a return to a steady-state current amplitude close to the prestimulus value, after a transient peak. In this article, we formulate a dynamical model of the olfactory transduction pathway, which includes the kinetics of the CNG channels, the concentration of Ca ions flowing through them, and the Ca-complexes responsible for the regulation. Based on this model, a common dynamical explanation for the two types of adaptation is suggested. We show that both forms of adaptation can be well described using different time constants for the kinetics of Ca ions (faster) and the kinetics of the feedback mechanisms (slower). The model is validated on experimental data collected in voltage-clamp conditions using different techniques and animal species.1 aDe Palo, Giovanna1 aBoccaccio, Anna1 aMiri, Andrew1 aMenini, Anna1 aAltafini, Claudio uhttp://hdl.handle.net/1963/701901400nas a2200169 4500008004100000245009000041210006900131260005000200520083200250100001401082700001801096700001501114700002201129700002201151700002101173856003601194 2011 en d00aAdaptation as a genome-wide autoregulatory principle in the stress response of yeast.0 aAdaptation as a genomewide autoregulatory principle in the stres bThe Institution of Engineering and Technology3 aThe gene expression response of yeast to various types of stresses/perturbations shows a common functional and dynamical pattern for the vast majority of genes, characterised by a quick transient peak (affecting primarily short genes) followed by a return to the pre-stimulus level. Kinetically, this process of adaptation following the transient excursion can be modelled using a genome-wide autoregulatory mechanism by means of which yeast aims at maintaining a preferential concentration in its mRNA levels. The resulting feedback system explains well the different time constants observable in the transient response, while being in agreement with all the known experimental dynamical features. For example, it suggests that a very rapid transient can be induced also by a slowly varying concentration of the gene products.1 aEduati, F1 aDi Camillo, B1 aToffolo, G1 aAltafini, Claudio1 aDe Palo, Giovanna1 aZampieri, Mattia uhttp://hdl.handle.net/1963/5106