00974nas a2200109   4500008004300000245009300043210006900136520057600205100002500781700002200806856003600828       2006                        en_Ud  00aAn estimation of the controllability time for single-input systems on compact Lie Groups0 aestimation of the controllability time for singleinput systems o3 aGeometric control theory and Riemannian techniques are used to describe the reachable set at time t of left invariant single-input control systems on semi-simple compact Lie groups and to estimate the minimal time needed to reach any point from identity. This method provides an effective way to give an upper and a lower bound for the minimal time needed to transfer a controlled quantum system with a drift from a given initial position to a given final position. The bounds include diameters of the flag manifolds; the latter are also explicitly computed in the paper.1 aAgrachev, Andrei, A.1 aChambrion, Thomas  uhttp://hdl.handle.net/1963/213502436nas a2200169   4500008004100000245007600041210006900117260007200186520184400258100002002102700002202122700001802144700002502162700001902187700002402206856003602230       2006                        en  d00aExperimental and modeling studies of desensitization of P2X3 receptors.0 aExperimental and modeling studies of desensitization of P2X3 rec  bthe American Society for Pharmacology and Experimental Therapeutics3 aThe function of ATP-activated P2X3 receptors involved in pain sensation is modulated by desensitization, a phenomenon poorly understood. The present study used patch-clamp recording from cultured rat or mouse sensory neurons and kinetic modeling to clarify the properties of P2X3 receptor desensitization. Two types of desensitization were observed, a fast process (t1/2 = 50 ms; 10 microM ATP) following the inward current evoked by micromolar agonist concentrations, and a slow process (t1/2 = 35 s; 10 nM ATP) that inhibited receptors without activating them. We termed the latter high-affinity desensitization (HAD). Recovery from fast desensitization or HAD was slow and agonist-dependent. When comparing several agonists, there was analogous ranking order for agonist potency, rate of desensitization and HAD effectiveness, with 2-methylthioadenosine triphosphate the strongest and beta,gamma-methylene-ATP the weakest. HAD was less developed with recombinant (ATP IC50 = 390 nM) than native P2X3 receptors (IC50 = 2.3 nM). HAD could also be induced by nanomolar ATP when receptors seemed to be nondesensitized, indicating that resting receptors could express high-affinity binding sites. Desensitization properties were well accounted for by a cyclic model in which receptors could be desensitized from either open or closed states. Recovery was assumed to be a multistate process with distinct kinetics dependent on the agonist-dependent dissociation rate from desensitized receptors. Thus, the combination of agonist-specific mechanisms such as desensitization onset, HAD, and resensitization could shape responsiveness of sensory neurons to P2X3 receptor agonists. By using subthreshold concentrations of an HAD-potent agonist, it might be possible to generate sustained inhibition of P2X3 receptors for controlling chronic pain.1 aSokolova, Elena1 aSkorinkin, Andrei1 aMoiseev, Igor1 aAgrachev, Andrei, A.1 aNistri, Andrea1 aGiniatullin, Rashid  uhttp://hdl.handle.net/1963/4974