02449nas a2200121   4500008004100000245012900041210006900170520189900239100002002138700002502158700001702183856012702200       2015                        en  d00aReduced Basis Isogeometric Methods (RB-IGA) for the real-time simulation of potential flows about parametrized NACA airfoils0 aReduced Basis Isogeometric Methods RBIGA for the realtime simula3 aWe present a Reduced Basis (RB) method based on Isogeometric Analysis (IGA) for the rapid and reliable evaluation of PDE systems characterized by complex geometrical features. At the current state of the art, this is the first case of coupling between RB and IGA methods. The construction of the RB method relies on an Isogeometric Boundary Element Method (IGA-BEM) as the high-fidelity technique, allowing a direct interface with Computer Aided Design (CAD) tools. A suitable Empirical Interpolation Method (EIM) ensures an efficient offline/online decomposition between the construction and the evaluation of the RB method. We consider the real-time simulation of potential flows past airfoils, parametrized with respect to the angle of attack and the NACA number identifying their shape, and we provide a validation of our methodology with respect to experimental data and reference numerical codes, showing in both cases a very good agreement.We present a Reduced Basis (RB) method based on Isogeometric Analysis (IGA) for the rapid and reliable evaluation of PDE systems characterized by complex geometrical features. At the current state of the art, this is the first case of coupling between RB and IGA methods. The construction of the RB method relies on an Isogeometric Boundary Element Method (IGA-BEM) as the high-fidelity technique, allowing a direct interface with Computer Aided Design (CAD) tools. A suitable Empirical Interpolation Method (EIM) ensures an efficient offline/online decomposition between the construction and the evaluation of the RB method. We consider the real-time simulation of potential flows past airfoils, parametrized with respect to the angle of attack and the NACA number identifying their shape, and we provide a validation of our methodology with respect to experimental data and reference numerical codes, showing in both cases a very good agreement.1 aManzoni, Andrea1 aSalmoiraghi, Filippo1 aHeltai, Luca  uhttps://www.math.sissa.it/publication/reduced-basis-isogeometric-methods-rb-iga-real-time-simulation-potential-flows-about02076nas a2200145   4500008004100000245004700041210004700088520166300135653001801798100001901816700001701835700002001852700002201872856003601894       2012                        en  d00aReverse engineering the euglenoid movement0 aReverse engineering the euglenoid movement3 aEuglenids exhibit an unconventional motility strategy amongst unicellular eukaryotes, consisting of large-amplitude highly concerted deformations of the entire body (euglenoid movement or metaboly). A plastic cell envelope called pellicle mediates these deformations. Unlike ciliary or flagellar motility, the biophysics of this mode is not well understood, including its efficiency and molecular machinery. We quantitatively examine video recordings of four euglenids executing such motions with statistical learning methods. This analysis reveals strokes of high uniformity in shape and pace. We then interpret the observations in the light of a theory for the pellicle kinematics, providing a precise understanding of the link between local actuation by pellicle shear and shape control. We systematically understand common observations, such as the helical conformations of the pellicle, and identify previously unnoticed features of metaboly. While two of our euglenids execute their stroke at constant body volume, the other two exhibit deviations of about 20% from their average volume, challenging current models of low Reynolds number locomotion. We find that the active pellicle shear deformations causing shape changes can reach 340%, and estimate the velocity of the molecular motors. Moreover, we find that metaboly accomplishes locomotion at hydrodynamic efficiencies comparable to those of ciliates and flagellates. Our results suggest new quantitative experiments, provide insight into the evolutionary history of euglenids, and suggest that the pellicle may serve as a model for engineered active surfaces with applications in microfluidics.10amicroswimmers1 aArroyo, Marino1 aHeltai, Luca1 aMillán, Daniel1 aDeSimone, Antonio  uhttp://hdl.handle.net/1963/644401810nas a2200121   4500008004300000245007000043210006600113520141500179100001901594700002201613700001701635856003601652       2010                        en_Ud  00aThe role of membrane viscosity in the dynamics of fluid membranes0 arole of membrane viscosity in the dynamics of fluid membranes3 aFluid membranes made out of lipid bilayers are the fundamental separation structure in eukaryotic cells. Many physiological processes rely on dramatic shape and topological changes (e.g. fusion, fission) of fluid membrane systems. Fluidity is key to the versatility and constant reorganization of lipid bilayers. Here, we study the role of the membrane intrinsic viscosity, arising from the friction of the lipid molecules as they rearrange to accommodate shape changes, in the dynamics of morphological changes of fluid vesicles. In particular, we analyze the competition between the membrane viscosity and the viscosity of the bulk fluid surrounding the vesicle as the dominant dissipative mechanism. We consider the relaxation dynamics of fluid vesicles put in an out-of-equilibrium state, but conclusions can be drawn regarding the kinetics or power consumption in regulated shape changes in the cell. On the basis of numerical calculations, we find that the dynamics arising from the membrane viscosity are qualitatively different from the dynamics arising from the bulk viscosity. When these two dissipation mechanisms are put in competition, we find that for small vesicles the membrane dissipation dominates, with a relaxation time that scales as the size of the vesicle to the power 2. For large vesicles, the bulk dissipation dominates, and the exponent in the relaxation time vs. size relation is 3.1 aArroyo, Marino1 aDeSimone, Antonio1 aHeltai, Luca  uhttp://hdl.handle.net/1963/3930