TY - JOUR T1 - Adaptation as a genome-wide autoregulatory principle in the stress response of yeast. JF - IET systems biology. 2011 Jul; 5(4):269-79 Y1 - 2011 A1 - F Eduati A1 - B Di Camillo A1 - G Toffolo A1 - Claudio Altafini A1 - Giovanna De Palo A1 - Mattia Zampieri AB - The gene expression response of yeast to various types of stresses/perturbations shows a common functional and dynamical pattern for the vast majority of genes, characterised by a quick transient peak (affecting primarily short genes) followed by a return to the pre-stimulus level. Kinetically, this process of adaptation following the transient excursion can be modelled using a genome-wide autoregulatory mechanism by means of which yeast aims at maintaining a preferential concentration in its mRNA levels. The resulting feedback system explains well the different time constants observable in the transient response, while being in agreement with all the known experimental dynamical features. For example, it suggests that a very rapid transient can be induced also by a slowly varying concentration of the gene products. PB - The Institution of Engineering and Technology UR - http://hdl.handle.net/1963/5106 U1 - 4922 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER -