TY - JOUR T1 - Simulation-based uncertainty quantification of human arterial network hemodynamics JF - International Journal Numerical Methods Biomedical Engineering Y1 - 2012 A1 - Peng Chen A1 - Alfio Quarteroni A1 - Gianluigi Rozza KW - uncertainty quantification, mathematical modelling of the cardiovascular system, fluid-structure interaction AB - This work aims at identifying and quantifying uncertainties from various sources in human cardiovascular\r\nsystem based on stochastic simulation of a one dimensional arterial network. A general analysis of\r\ndifferent uncertainties and probability characterization with log-normal distribution of these uncertainties\r\nis introduced. Deriving from a deterministic one dimensional fluid structure interaction model, we establish\r\nthe stochastic model as a coupled hyperbolic system incorporated with parametric uncertainties to describe\r\nthe blood flow and pressure wave propagation in the arterial network. By applying a stochastic collocation\r\nmethod with sparse grid technique, we study systemically the statistics and sensitivity of the solution with\r\nrespect to many different uncertainties in a relatively complete arterial network with potential physiological\r\nand pathological implications for the first time. PB - Wiley U1 - 6467 U2 - Mathematics U4 - 1 U5 - MAT/08 ANALISI NUMERICA ER -