TY - JOUR T1 - Numerical modeling of hemodynamics scenarios of patient-specific coronary artery bypass grafts JF - Biomechanics and Modeling in Mechanobiology Y1 - 2017 A1 - F. Ballarin A1 - Elena Faggiano A1 - Andrea Manzoni A1 - Alfio Quarteroni A1 - Gianluigi Rozza A1 - Sonia Ippolito A1 - Roberto Scrofani VL - 16 UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015065851&doi=10.1007%2fs10237-017-0893-7&partnerID=40&md5=c388f20bd5de14187bad9ed7d9affbd0 ER - TY - RPRT T1 - A fast virtual surgery platform for many scenarios haemodynamics of patient-specific coronary artery bypass grafts Y1 - 2016 A1 - F. Ballarin A1 - Elena Faggiano A1 - Andrea Manzoni A1 - Gianluigi Rozza A1 - Alfio Quarteroni A1 - Sonia Ippolito A1 - Roberto Scrofani A1 - Carlo Antona AB - A fast computational framework is devised to the study of several configurations of patient-specific coronary artery bypass grafts. This is especially useful to perform a sensitivity analysis of the haemodynamics for different flow conditions occurring in native coronary arteries and bypass grafts, the investigation of the progression of the coronary artery disease and the choice of the most appropriate surgical procedure. A complete pipeline, from the acquisition of patientspecific medical images to fast parametrized computational simulations, is proposed. Complex surgical configurations employed in the clinical practice, such as Y-grafts and sequential grafts, are studied. A virtual surgery platform based on model reduction of unsteady Navier Stokes equations for blood dynamics is proposed to carry out sensitivity analyses in a very rapid and reliable way. A specialized geometrical parametrization is employed to compare the effect of stenosis and anastomosis variation on the outcome of the surgery in several relevant cases. PB - Submitted UR - http://urania.sissa.it/xmlui/handle/1963/35240 U1 - 35545 U2 - Mathematics U4 - 1 U5 - MAT/08 ER - TY - RPRT T1 - Fast simulations of patient-specific haemodynamics of coronary artery bypass grafts based on a POD-Galerkin method and a vascular shape parametrization Y1 - 2015 A1 - F. Ballarin A1 - Elena Faggiano A1 - Sonia Ippolito A1 - Andrea Manzoni A1 - Alfio Quarteroni A1 - Gianluigi Rozza A1 - Roberto Scrofani AB - In this work a reduced-order computational framework for the study of haemodynamics in three-dimensional patient-specific configurations of coronary artery bypass grafts dealing with a wide range of scenarios is proposed. We combine several efficient algorithms to face at the same time both the geometrical complexity involved in the description of the vascular network and the huge computational cost entailed by time dependent patient-specific flow simulations. Medical imaging procedures allow to reconstruct patient-specific configurations from clinical data. A centerlines-based parametrization is proposed to efficiently handle geometrical variations. POD–Galerkin reduced-order models are employed to cut down large computational costs. This computational framework allows to characterize blood flows for different physical and geometrical variations relevant in the clinical practice, such as stenosis factors and anastomosis variations, in a rapid and reliable way. Several numerical results are discussed, highlighting the computational performance of the proposed framework, as well as its capability to perform sensitivity analysis studies, so far out of reach. UR - http://urania.sissa.it/xmlui/handle/1963/34623 U1 - 34824 U2 - Mathematics U4 - 1 U5 - MAT/08 ER -