Mathematical modeling and quantitative study of biological motility (in particular, of motility at microscopic scales) is producing new biophysical insight and is offering opportunities for new discoveries at the level of both fundamental science and technology. These range from the explanation of how complex behavior at the level of a single organism emerges from body architecture, to the understanding of collective phenomena in groups of organisms and tissues, and of how these forms of swarm intelligence can be controlled and harnessed in engineering applications, to the elucidation of processes of fundamental biological relevance at the cellular and sub-cellular level. In this paper, some of the most exciting new developments in the fields of locomotion of unicellular organisms, of soft adhesive locomotion across scales, of the study of pore translocation properties of knotted DNA, of the development of synthetic active solid sheets, of the mechanics of the unjamming transition in dense cell collectives, of the mechanics of cell sheet folding in volvocalean algae, and of the self-propulsion of topological defects in active matter are discussed. For each of these topics, we provide a brief state of the art, an example of recent achievements, and some directions for future research.

VL - 2 UR - http://dx.doi.org/10.3934/mine.2020011 ER - TY - JOUR T1 - Activation of a muscle as a mapping of stress–strain curves JF - Extreme Mech. Lett. Y1 - 2019 A1 - Davide Riccobelli A1 - D. Ambrosi PB - Elsevier BV VL - 28 ER - TY - JOUR T1 - On the existence of elastic minimizers for initially stressed materials JF - Phil. Trans. R. Soc. A Y1 - 2019 A1 - Davide Riccobelli A1 - A. Agosti A1 - Pasquale Ciarletta PB - The Royal Society VL - 377 ER - TY - JOUR T1 - Nutations in growing plant shoots: The role of elastic deformations due to gravity loading JF - Journal of the Mechanics and Physics of Solids Y1 - 2019 A1 - Daniele Agostinelli A1 - Alessandro Lucantonio A1 - Giovanni Noselli A1 - Antonio DeSimone KW - Circumnutations KW - Flutter instability KW - Gravitropism KW - Hopf bifurcation AB -The effect of elastic deformations induced by gravity loading on the active circumnutation movements of growing plant shoots is investigated. We consider first a discrete model (a gravitropic spring-pendulum system) and then a continuous rod model which is analyzed both analytically (under the assumption of small deformations) and numerically (in the large deformation regime). We find that, for a choice of material parameters consistent with values reported in the available literature on plant shoots, rods of sufficient length may exhibit lateral oscillations of increasing amplitude, which eventually converge to limit cycles. This behavior strongly suggests the occurrence of a Hopf bifurcation, just as for the gravitropic spring-pendulum system, for which this result is rigorously established. At least in this restricted set of material parameters, our analysis supports a view of Darwin’s circumnutations as a biological analogue to structural systems exhibiting flutter instabilities, i.e., spontaneous oscillations away from equilibrium configurations driven by non-conservative loads. Here, in the context of nutation movements of growing plant shoots, the energy needed to sustain oscillations is continuously supplied to the system by the internal biochemical machinery presiding the capability of plants to maintain a vertical pose.

UR - https://doi.org/10.1016/j.jmps.2019.103702 ER - TY - JOUR T1 - Strong Novikov conjecture for low degree cohomology and exotic group C*-algebras JF - arXiv e-prints Y1 - 2019 A1 - Paolo Antonini A1 - Buss, Alcides A1 - Engel, Alexander A1 - Siebenand , Timo KW - Mathematics - K-Theory and Homology KW - Mathematics - Operator Algebras AB -We strengthen a result of Hanke–Schick about the strong Novikov conjecture for low degree cohomology by showing that their non-vanishing result for the maximal group $C^*$-algebra even holds for the reduced group $C^*$-algebra. To achieve this we provide a Fell absorption principle for certain exotic crossed product functors.

ER - TY - JOUR T1 - The Baum–Connes conjecture localised at the unit element of a discrete group JF - ArXiv e-prints Y1 - 2018 A1 - Paolo Antonini A1 - Azzali, S. A1 - Skandalis, G. KW - 19K35 KW - 46L80 KW - 46L85 KW - 58J22 KW - Mathematics - K-Theory and Homology KW - Mathematics - Operator Algebras ER - TY - CHAP T1 - Computational methods in cardiovascular mechanics T2 - Cardiovascular Mechanics Y1 - 2018 A1 - Auricchio, Ferdinando A1 - Conti, Michele A1 - Lefieux, Adrian A1 - Morganti, Simone A1 - Alessandro Reali A1 - Gianluigi Rozza A1 - Veneziani, Alessandro ED - Michel F. Labrosse AB -The introduction of computational models in cardiovascular sciences has been progressively bringing new and unique tools for the investigation of the physiopathology. Together with the dramatic improvement of imaging and measuring devices on one side, and of computational architectures on the other one, mathematical and numerical models have provided a new, clearly noninvasive, approach for understanding not only basic mechanisms but also patient-specific conditions, and for supporting the design and the development of new therapeutic options. The terminology in silico is, nowadays, commonly accepted for indicating this new source of knowledge added to traditional in vitro and in vivo investigations. The advantages of in silico methodologies are basically the low cost in terms of infrastructures and facilities, the reduced invasiveness and, in general, the intrinsic predictive capabilities based on the use of mathematical models. The disadvantages are generally identified in the distance between the real cases and their virtual counterpart required by the conceptual modeling that can be detrimental for the reliability of numerical simulations.

JF - Cardiovascular Mechanics PB - CRC Press UR - https://www.taylorfrancis.com/books/e/9781315280288/chapters/10.1201%2Fb21917-5 ER - TY - JOUR T1 - The deal.II Library, Version 9.0 JF - JOURNAL OF NUMERICAL MATHEMATICS Y1 - 2018 A1 - Giovanni Alzetta A1 - Arndt, Daniel A1 - W. Bangerth A1 - Boddu, Vishal A1 - Brands, Benjamin A1 - Denis Davydov A1 - Gassmöller, Rene A1 - Timo Heister A1 - Luca Heltai A1 - Kormann, Katharina A1 - Martin Kronbichler A1 - Matthias Maier A1 - Pelteret, Jean-Paul A1 - B. Turcksin A1 - David Wells UR - https://doi.org/10.1515/jnma-2018-0054 ER - TY - ABST T1 - The Effort of Increasing Reynolds Number in Projection-Based Reduced Order Methods: from Laminar to Turbulent Flows Y1 - 2018 A1 - Saddam Hijazi A1 - Shafqat Ali A1 - Giovanni Stabile A1 - Francesco Ballarin A1 - Gianluigi Rozza ER - TY - RPRT T1 - Foldable structures made of hydrogel bilayers Y1 - 2018 A1 - Virginia Agostiniani A1 - Antonio DeSimone A1 - Alessandro Lucantonio A1 - Danka Lučić ER - TY - JOUR T1 - Global, finite energy, weak solutions for the NLS with rough, time-dependent magnetic potentials JF - Zeitschrift für angewandte Mathematik und Physik Y1 - 2018 A1 - Paolo Antonelli A1 - Alessandro Michelangeli A1 - Raffaele Scandone AB -We prove the existence of weak solutions in the space of energy for a class of nonlinear Schrödinger equations in the presence of a external, rough, time-dependent magnetic potential. Under our assumptions, it is not possible to study the problem by means of usual arguments like resolvent techniques or Fourier integral operators, for example. We use a parabolic regularisation, and we solve the approximating Cauchy problem. This is achieved by obtaining suitable smoothing estimates for the dissipative evolution. The total mass and energy bounds allow to extend the solution globally in time. We then infer sufficient compactness properties in order to produce a global-in-time finite energy weak solution to our original problem.

VL - 69 UR - https://doi.org/10.1007/s00033-018-0938-5 ER - TY - JOUR T1 - Heterogeneous elastic plates with in-plane modulation of the target curvature and applications to thin gel sheets JF - ESAIM: Control, Optimisation and Calculus of Variations Y1 - 2018 A1 - Virginia Agostiniani A1 - Alessandro Lucantonio A1 - Danka Lučić PB - EDP Sciences ER - TY - JOUR T1 - A Localized Reduced-Order Modeling Approach for PDEs with Bifurcating Solutions JF - ArXiv e-prints Y1 - 2018 A1 - Martin W. Hess A1 - A. Alla A1 - Annalisa Quaini A1 - Gianluigi Rozza A1 - M. Gunzburger KW - Mathematics - Numerical Analysis ER - TY - JOUR T1 - Peristaltic Waves as Optimal Gaits in Metameric Bio-Inspired Robots JF - Frontiers in Robotics and AI Y1 - 2018 A1 - Daniele Agostinelli A1 - François Alouges A1 - Antonio DeSimone KW - Biomimetic robots KW - Crawling motility KW - Lumbricus terrestris KW - Metameric robots KW - Optimization KW - Peristalsis KW - Self-propulsion KW - Soft robotics AB -*Peristalsis*, i.e., a motion pattern arising from the propagation of muscle contraction and expansion waves along the body, is a common locomotion strategy for limbless animals. Mimicking peristalsis in bio-inspired robots has attracted considerable attention in the literature. It has recently been observed that maximal velocity in a metameric earthworm-like robot is achieved by actuating the segments using a “phase coordination” principle. This paper shows that, in fact, peristalsis (which requires not only phase coordination, but also that all segments oscillate at same frequency and amplitude) emerges from optimization principles. More precisely, basing our analysis on the assumption of small deformations, we show that peristaltic waves provide the optimal actuation solution in the ideal case of a periodic infinite system, and that this is approximately true, modulo edge effects, for the real, finite length system. Therefore, this paper confirms the effectiveness of mimicking peristalsis in bio-inspired robots, at least in the small-deformation regime. Further research will be required to test the effectiveness of this strategy if large deformations are allowed.

In the setting of planar linearized elasticity, we study a fracture model depending on the crack opening. Assuming that the crack path is known a priori and sufficiently smooth, we prove that the energy release rate is well defined. Then, we consider the problem of quasi-static evolution for our model. Thanks to a vanishing viscosity approach, we show the existence of such an evolution satisfying a weak Griffith’s criterion.

PB - EDP Sciences VL - 23 UR - https://www.esaim-cocv.org/component/article?access=doi&doi=10.1051/cocv/2016014 ER - TY - RPRT T1 - Friedrichs systems in a Hilbert space framework: solvability and multiplicity Y1 - 2017 A1 - Nenad Antonić A1 - Marko Erceg A1 - Alessandro Michelangeli AB - The Friedrichs (1958) theory of positive symmetric systems of first order partial differential equations encompasses many standard equations of mathematical physics, irrespective of their type. This theory was recast in an abstract Hilbert space setting by Ern, Guermond and Caplain (2007), and by Antonić and Burazin (2010). In this work we make a further step, presenting a purely operator-theoretic description of abstract Friedrichs systems, and proving that any pair of abstract Friedrichs operators admits bijective extensions with a signed boundary map. Moreover, we provide suffcient and necessary conditions for existence of infinitely many such pairs of spaces, and by the universal operator extension theory (Grubb, 1968) we get a complete identification of all such pairs, which we illustrate on two concrete one-dimensional examples. UR - http://preprints.sissa.it/handle/1963/35280 U1 - 35587 U2 - Mathematics U4 - 1 ER - TY - JOUR T1 - Homotopically invisible singular curves JF - Calculus of Variations and Partial Differential Equations Y1 - 2017 A1 - Andrei A. Agrachev A1 - Francesco Boarotto A1 - Antonio Lerario VL - 56 UR - https://doi.org/10.1007/s00526-017-1203-z ER - TY - JOUR T1 - The injectivity radius of Lie manifolds JF - ArXiv e-prints Y1 - 2017 A1 - Paolo Antonini A1 - Guido De Philippis A1 - Nicola Gigli KW - (58J40) KW - 53C21 KW - Mathematics - Differential Geometry AB -We prove in a direct, geometric way that for any compatible Riemannian metric on a Lie manifold the injectivity radius is positive

UR - https://arxiv.org/pdf/1707.07595.pdf ER - TY - JOUR T1 - Integrable lifts for transitive Lie algebroids JF - ArXiv e-prints Y1 - 2017 A1 - Androulidakis, I. A1 - Paolo Antonini KW - 14F40 KW - 58H05 KW - Mathematics - Differential Geometry AB -Inspired by the work of Molino, we show that the integrability obstruction for transitive Lie algebroids can be made to vanish by adding extra dimensions. In particular, we prove that the Weinstein groupoid of a non-integrable transitive and abelian Lie algebroid, is the quotient of a finite dimensional Lie groupoid. Two constructions as such are given: First, explaining the counterexample to integrability given by Almeida and Molino, we see that it can be generalized to the construction of an "Almeida-Molino" integrable lift when the base manifold is simply connected. On the other hand, we notice that the classical de Rham isomorphism provides a universal integrable algebroid. Using it we construct a "de Rham" integrable lift for any given transitive Abelian Lie algebroid.

UR - https://arxiv.org/pdf/1707.04855.pdf ER - TY - RPRT T1 - Linearisation of multiwell energies Y1 - 2017 A1 - Roberto Alicandro A1 - Gianni Dal Maso A1 - Giuliano Lazzaroni A1 - Mariapia Palombaro AB - Linear elasticity can be rigorously derived from finite elasticity under the assumption of small loadings in terms of Gamma-convergence. This was first done in the case of one-well energies with super-quadratic growth and later generalised to different settings, in particular to the case of multi-well energies where the distance between the wells is very small (comparable to the size of the load). In this paper we study the case when the distance between the wells is independent of the size of the load. In this context linear elasticity can be derived by adding to the multi-well energy a singular higher order term which penalises jumps from one well to another. The size of the singular term has to satisfy certain scaling assumptions whose optimality is shown in most of the cases. Finally, the derivation of linear elasticty from a two-well discrete model is provided, showing that the role of the singular perturbation term is played in this setting by interactions beyond nearest neighbours. UR - http://preprints.sissa.it/handle/1963/35288 U1 - 35594 U2 - Mathematics U4 - 1 ER - TY - JOUR T1 - A lower semicontinuity result for a free discontinuity functional with a boundary term JF - Journal de Mathématiques Pures et Appliquées Y1 - 2017 A1 - Stefano Almi A1 - Gianni Dal Maso A1 - Rodica Toader AB -We study the lower semicontinuity in $GSBV^{p}(\Omega;\mathbb{R}^{m})$ of a free discontinuity functional $\mathcal{F}(u)$ that can be written as the sum of a crack term, depending only on the jump set $S_{u}$, and of a boundary term, depending on the trace of $u$ on $\partial\Omega$. We give sufficient conditions on the integrands for the lower semicontinuity of $\mathcal{F}$. Moreover, we prove a relaxation result, which shows that, if these conditions are not satisfied, the lower semicontinuous envelope of $\mathcal{F}$ can be represented by the sum of two integrals on $S_{u}$ and $\partial\Omega$, respectively.

VL - 108 UR - http://hdl.handle.net/20.500.11767/15979 IS - 6 U1 - 34731 U2 - Mathematics U4 - 1 U5 - MAT/05 ER - TY - JOUR T1 - Solid tumors are poroelastic solids with a chemo-mechanical feedback on growth JF - J. Elast. Y1 - 2017 A1 - D. Ambrosi A1 - Pezzuto, S. A1 - Davide Riccobelli A1 - Stylianopoulos, T. A1 - Pasquale Ciarletta PB - Springer Netherlands VL - 129 ER - TY - RPRT T1 - Eulerian, Lagrangian and Broad continuous solutions to a balance law with non convex flux II Y1 - 2016 A1 - Giovanni Alberti A1 - Stefano Bianchini A1 - Laura Caravenna UR - http://urania.sissa.it/xmlui/handle/1963/35197 U1 - 35494 U2 - Mathematics ER - TY - JOUR T1 - Eulerian, Lagrangian and Broad continuous solutions to a balance law with non-convex flux I JF - Journal of Differential Equations, vol. 261, issue 8 (2016): 4298-4337 Y1 - 2016 A1 - Giovanni Alberti A1 - Stefano Bianchini A1 - Laura Caravenna PB - Elsevier UR - http://urania.sissa.it/xmlui/handle/1963/35207 U1 - 35507 U2 - Mathematics ER - TY - RPRT T1 - A fast virtual surgery platform for many scenarios haemodynamics of patient-specific coronary artery bypass grafts Y1 - 2016 A1 - Francesco Ballarin A1 - Elena Faggiano A1 - Andrea Manzoni A1 - Gianluigi Rozza A1 - Alfio Quarteroni A1 - Sonia Ippolito A1 - Roberto Scrofani A1 - Carlo Antona AB - A fast computational framework is devised to the study of several configurations of patient-specific coronary artery bypass grafts. This is especially useful to perform a sensitivity analysis of the haemodynamics for different flow conditions occurring in native coronary arteries and bypass grafts, the investigation of the progression of the coronary artery disease and the choice of the most appropriate surgical procedure. A complete pipeline, from the acquisition of patientspecific medical images to fast parametrized computational simulations, is proposed. Complex surgical configurations employed in the clinical practice, such as Y-grafts and sequential grafts, are studied. A virtual surgery platform based on model reduction of unsteady Navier Stokes equations for blood dynamics is proposed to carry out sensitivity analyses in a very rapid and reliable way. A specialized geometrical parametrization is employed to compare the effect of stenosis and anastomosis variation on the outcome of the surgery in several relevant cases. PB - Submitted UR - http://urania.sissa.it/xmlui/handle/1963/35240 U1 - 35545 U2 - Mathematics U4 - 1 U5 - MAT/08 ER - TY - JOUR T1 - The Gysin sequence for quantum lens spaces JF - Journal of Noncommutative Geometry Y1 - 2016 A1 - Francesca Arici A1 - Simon Brain A1 - Giovanni Landi AB -We define quantum lens spaces as ‘direct sums of line bundles’ and exhibit them as ‘total spaces’ of certain principal bundles over quantum projective spaces. For each of these quantum lens spaces we construct an analogue of the classical Gysin sequence in K-theory. We use the sequence to compute the K-theory of the quantum lens spaces, in particular to give explicit geometric representatives of their K-theory classes. These representatives are interpreted as ‘line bundles’ over quantum lens spaces and generically define ‘torsion classes’. We work out explicit examples of these classes.

VL - 9 ER - TY - CHAP T1 - Pimsner Algebras and Circle Bundles T2 - Noncommutative Analysis, Operator Theory and Applications Y1 - 2016 A1 - Francesca Arici A1 - Francesco D'Andrea A1 - Giovanni Landi ED - Alpay, Daniel ED - Cipriani, Fabio ED - Colombo, Fabrizio ED - Guido, Daniele ED - Sabadini, Irene ED - Sauvageot, Jean-Luc AB -We report on the connections between noncommutative principal circle bundles, Pimsner algebras and strongly graded algebras. We illustrate several results with examples of quantum weighted projective and lens spaces and θ-deformations.

JF - Noncommutative Analysis, Operator Theory and Applications PB - Springer International Publishing CY - Cham SN - 978-3-319-29116-1 UR - https://doi.org/10.1007/978-3-319-29116-1_1 ER - TY - JOUR T1 - Pimsner algebras and Gysin sequences from principal circle actions JF - Journal of Noncommutative Geometry Y1 - 2016 A1 - Francesca Arici A1 - Jens Kaad A1 - Giovanni Landi VL - 10 UR - http://hdl.handle.net/2066/162951 ER - TY - RPRT T1 - Quasi-static hydraulic crack growth driven by Darcy's law Y1 - 2016 A1 - Stefano Almi AB -In the framework of rate independent processes, we present a variational model of quasi-static crack growth in hydraulic fracture. We first introduce the energy functional and study the equilibrium conditions of an unbounded linearly elastic body subject to a remote strain ε ∈ R and with a sufficiently regular crack Γ filled by a volume V of incompressible fluid. In particular, we are able to find the pressure p of the fluid inside the crack as a function of Γ, V , and ε. Then, we study the problem of quasi-static evolution for our model, imposing that the fluid volume V and the fluid pressure p are related by Darcy’s law. We show the existence of such an evolution, and we prove that it satisfies a weak notion of the so-called Griffith’s criterion.

UR - http://urania.sissa.it/xmlui/handle/1963/35198 U1 - 35492 U2 - Mathematics U4 - 1 U5 - MAT/05 ER - TY - THES T1 - Some results on the mathematical analysis of crack problems with forces applied on the fracture lips Y1 - 2016 A1 - Stefano Almi KW - Fracture mechanics AB - This thesis is devoted to the study of some models of fracture growth in elastic materials, characterized by the presence of forces acting on the crack lips. Working in the general framework of rate-independent processes, we first discuss a variational formulation of the problem of quasi-static crack evolution in hydraulic fracture. Then, we investigate the crack growth process in a cohesive fracture model, showing the existence of an evolution satisfying a weak Griffith's criterion. Finally, in the last chapter of this work we investigate, in the static case, the interaction between the energy spent in order to create a new fracture and the energy spent by the applied surface forces. This leads us to study the lower semicontinuity properties of a free discontinuity functional F(u) that can be written as the sum of a crack term, depending on the jump set of u, and of a boundary term, depending on the trace of u. PB - SISSA U1 - 35503 U2 - Mathematics U4 - 1 U5 - MAT/05 ER - TY - JOUR T1 - Volume geodesic distortion and Ricci curvature for Hamiltonian dynamics JF - arXiv preprint arXiv:1602.08745 Y1 - 2016 A1 - Andrei A. Agrachev A1 - Davide Barilari A1 - Elisa Paoli ER - TY - JOUR T1 - Anisotropic mean curvature on facets and relations with capillarity Y1 - 2015 A1 - Stefano Amato A1 - Lucia Tealdi A1 - Giovanni Bellettini AB -We discuss the relations between the anisotropic calibrability of a facet F of a solid crystal E, and the capillary problem on a capillary tube with base F. When F is parallel to a facet of the Wulff shape, calibrability is equivalent to show the existence of an anisotropic subunitary vector field in $F, with suitable normal trace on the boundary of the facet, and with constant divergence equal to the anisotropic mean curvature of F. When the Wulff shape is a cylynder, assuming E convex at F, and F (strictly) calibrable, such a vector field is obtained by solving the capillary problem on F in absence of gravity and with zero contact angle. We show some examples of facets for which it is possible, even without the strict calibrability assumption, to build one of these vector fields. The construction provides, at least for convex facets of class C^{1,1}, the solution of the total variation flow starting at 1_F.

PB - de Gruyter UR - http://urania.sissa.it/xmlui/handle/1963/34481 U1 - 34663 U2 - Mathematics U4 - 1 U5 - MAT/05 ER - TY - JOUR T1 - Constrained BV functions on double coverings for Plateau's type problems JF - Adv. Calc. Var. Y1 - 2015 A1 - Stefano Amato A1 - Giovanni Bellettini A1 - Maurizio Paolini AB -We link Brakke's "soap films" covering construction with the theory of finite perimeter sets, in order to study Plateau's problem without fixing a priori the topology of the solution. The minimization is set up in the class of $BV$ functions defined on a double covering space of the complement of an $(n − 2)$-dimensional smooth compact manifold $S$ without boundary. The main novelty of our approach stands in the presence of a suitable constraint on the fibers, which couples together the covering sheets. The model allows to avoid all issues concerning the presence of the boundary $S$. The constraint is lifted in a natural way to Sobolev spaces, allowing also an approach based on $Γ$-convergence theory.

U1 - 7597 ER - TY - JOUR T1 - Geodesics and horizontal-path spaces in Carnot groups JF - Geometry & Topology Y1 - 2015 A1 - Andrei A. Agrachev A1 - Alessandro Gentile A1 - Antonio Lerario AB -We study properties of the space of horizontal paths joining the origin with a vertical point on a generic two-step Carnot group. The energy is a Morse-Bott functional on paths and its critical points (sub-Riemannian geodesics) appear in families (compact critical manifolds) with controlled topology. We study the asymptotic of the number of critical manifolds as the energy grows. The topology of the horizontal-path space is also investigated, and we find asymptotic results for the total Betti number of the sublevels of the energy as it goes to infinity. We interpret these results as local invariants of the sub-Riemannian structure.

PB - Mathematical Sciences Publishers VL - 19 ER - TY - JOUR T1 - The phototransduction machinery in the rod outer segment has a strong efficacy gradient Y1 - 2015 A1 - Monica Mazzolini A1 - Giuseppe Facchetti A1 - L. Andolfi A1 - R. Proietti Zaccaria A1 - S. Tuccio A1 - J. Treud A1 - Claudio Altafini A1 - Enzo M. Di Fabrizio A1 - Marco Lazzarino A1 - G. Rapp A1 - Vincent Torre PB - National Academy of Sciences UR - http://urania.sissa.it/xmlui/handle/1963/35157 N1 - Open Access article U1 - 35382 U2 - Neuroscience ER - TY - THES T1 - Principal circle bundles, Pimsner algebras and Gysin sequences Y1 - 2015 A1 - Francesca Arici AB - Principal circle bundles and Gysin sequences play a crucial role in mathematical physics, in particular in Chern-Simons theories and T-duality. This works focuses on the noncommutative topology of principal circle bundles: we investigate the connections between noncommutative principal circle bundles, Pimsner algebras and strongly graded algebras. At the C*-algebraic level, we start from a self-Morita equivalence bimodule E for a C*-algebra B which we think of as a non commutative line bundle over the `base space’ algebra B. The corresponding Pimsner algebra O_E, is then the total space algebra of an associated circle bundle. A natural six term exact sequence, an analogue of the Gysin sequence for circle bundles, relates the KK-theories of O_E and of the base space B. We illustrate several results with the examples of quantum weighted projective and lens spaces. PB - SISSA U1 - 34744 U2 - Mathematics U4 - 1 U5 - MAT/07 ER - TY - THES T1 - Some results on anisotropic mean curvature and other phase-transition problems Y1 - 2015 A1 - Stefano Amato KW - Anisotropic mean curvature AB - The present thesis is divided into three parts. In the first part, we analyze a suitable regularization — which we call nonlinear multidomain model — of the motion of a hypersurface under smooth anisotropic mean curvature flow. The second part of the thesis deals with crystalline mean curvature of facets of a solid set of R^3 . Finally, in the third part we study a phase-transition model for Plateau’s type problems based on the theory of coverings and of BV functions. PB - SISSA U1 - 34733 U2 - Mathematics U4 - 1 U5 - MAT/05 ER - TY - JOUR T1 - Achieving unanimous opinions in signed social networks Y1 - 2014 A1 - Claudio Altafini A1 - Gabriele Lini AB - Being able to predict the outcome of an opinion forming process is an important problem in social network theory. However, even for linear dynamics, this becomes a difficult task as soon as non-cooperative interactions are taken into account. Such interactions are naturally modeled as negative weights on the adjacency matrix of the social network. In this paper we show how the Perron-Frobenius theorem can be used for this task also beyond its standard formulation for cooperative systems. In particular we show how it is possible to associate the achievement of unanimous opinions with the existence of invariant cones properly contained in the positive orthant. These cases correspond to signed adjacency matrices having the eventual positivity property, i.e., such that in sufficiently high powers all negative entries have disappeared. More generally, we show how for social networks the achievement of a, possibily non-unanimous, opinion can be associated to the existence of an invariant cone fully contained in one of the orthants of n. PB - Institute of Electrical and Electronics Engineers Inc. UR - http://urania.sissa.it/xmlui/handle/1963/34935 U1 - 35137 U2 - Mathematics U4 - 1 ER - TY - JOUR T1 - On conjugate times of LQ optimal control problems Y1 - 2014 A1 - Andrei A. Agrachev A1 - Luca Rizzi A1 - Pavel Silveira KW - Optimal control, Lagrange Grassmannian, Conjugate point AB - Motivated by the study of linear quadratic optimal control problems, we consider a dynamical system with a constant, quadratic Hamiltonian, and we characterize the number of conjugate times in terms of the spectrum of the Hamiltonian vector field $\vec{H}$. We prove the following dichotomy: the number of conjugate times is identically zero or grows to infinity. The latter case occurs if and only if $\vec{H}$ has at least one Jordan block of odd dimension corresponding to a purely imaginary eigenvalue. As a byproduct, we obtain bounds from below on the number of conjugate times contained in an interval in terms of the spectrum of $\vec{H}$. PB - Springer UR - http://hdl.handle.net/1963/7227 N1 - 14 pages, 1 figure U1 - 7261 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - JOUR T1 - On the Lp-differentiability of certain classes of functions Y1 - 2014 A1 - Giovanni Alberti A1 - Stefano Bianchini A1 - Gianluca Crippa AB - We prove the Lp-differentiability at almost every point for convolution products on ℝd of the form K*μ, where μ is bounded measure and K is a homogeneous kernel of degree 1-d. From this result we derive the Lp-differentiability for vector fields on R d whose curl and divergence are measures, and also for vector fields with bounded deformation. PB - European Mathematical Society UR - http://urania.sissa.it/xmlui/handle/1963/34695 U1 - 34909 U2 - Mathematics U4 - 1 U5 - MAT/05 ER - TY - JOUR T1 - New results on Gamma-limits of integral functionals Y1 - 2014 A1 - Nadia Ansini A1 - Gianni Dal Maso A1 - Caterina Ida Zeppieri KW - Gamma-convergence PB - Elsevier UR - http://hdl.handle.net/1963/5880 U1 - 5745 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - Nonsingular Isogeometric Boundary Element Method for Stokes Flows in 3D Y1 - 2014 A1 - Luca Heltai A1 - Marino Arroyo A1 - Antonio DeSimone KW - Isogeometric Analysis AB - Isogeometric analysis (IGA) is emerging as a technology bridging Computer Aided Geometric Design (CAGD), most commonly based on Non-Uniform Rational B-Splines (NURBS) surfaces, and engineering analysis. In finite element and boundary element isogeometric methods (FE-IGA and IGA-BEM), the NURBS basis functions that de- scribe the geometry define also the approximation spaces. In the FE-IGA approach, the surfaces generated by the CAGD tools need to be extended to volumetric descriptions, a major open problem in 3D. This additional passage can be avoided in principle when the partial differential equations to be solved admit a formulation in terms of bound- ary integral equations, leading to Boundary Element Isogeometric Analysis (IGA-BEM). The main advantages of such an approach are given by the dimensionality reduction of the problem (from volumetric-based to surface-based), by the fact that the interface with CAGD tools is direct, and by the possibility to treat exterior problems, where the computational domain is infinite. By contrast, these methods produce system matrices which are full, and require the integration of singular kernels. In this paper we address the second point and propose a nonsingular formulation of IGA-BEM for 3D Stokes flows, whose convergence is carefully tested numerically. Standard Gaussian quadrature rules suffice to integrate the boundary integral equations, and carefully chosen known exact solutions of the interior Stokes problem are used to correct the resulting matrices, extending the work by Klaseboer et al. [27] to IGA-BEM. PB - Elsevier UR - http://hdl.handle.net/1963/6326 U1 - 6250 U2 - Mathematics U4 - 1 U5 - MAT/08 ANALISI NUMERICA ER - TY - JOUR T1 - Quasi-static crack growth in hydraulic fracture JF - Nonlinear Analysis Y1 - 2014 A1 - Stefano Almi A1 - Gianni Dal Maso A1 - Rodica Toader AB -We present a variational model for the quasi-static crack growth in hydraulic fracture in the framework of the energy formulation of rate-independent processes. The cracks are assumed to lie on a prescribed plane and to satisfy a very weak regularity assumption.

PB - Elsevier VL - 109 UR - http://hdl.handle.net/20.500.11767/17350 IS - Nov U1 - 34741 U2 - Mathematics U4 - 1 U5 - MAT/05 ER - TY - CHAP T1 - Reduction on characteristics for continuous of a scalar balance law T2 - AIMS Series on Applied Mathematics, vol. 8 (2014): 399 - 406 Y1 - 2014 A1 - Giovanni Alberti A1 - Stefano Bianchini A1 - Laura Caravenna KW - Method of characteristics JF - AIMS Series on Applied Mathematics, vol. 8 (2014): 399 - 406 PB - SISSA UR - http://hdl.handle.net/1963/6562 U1 - 6516 U2 - Mathematics U4 - 1 ER - TY - JOUR T1 - Shape control of active surfaces inspired by the movement of euglenids Y1 - 2014 A1 - Marino Arroyo A1 - Antonio DeSimone AB - We examine a novel mechanism for active surface morphing inspired by the cell body deformations of euglenids. Actuation is accomplished through in-plane simple shear along prescribed slip lines decorating the surface. Under general non-uniform actuation, such local deformation produces Gaussian curvature, and therefore leads to shape changes. Geometrically, a deformation that realizes the prescribed local shear is an isometric embedding. We explore the possibilities and limitations of this bio-inspired shape morphing mechanism, by first characterizing isometric embeddings under axisymmetry, understanding the limits of embeddability, and studying in detail the accessibility of surfaces of zero and constant curvature. Modeling mechanically the active surface as a non-Euclidean plate (NEP), we further examine the mechanism beyond the geometric singularities arising from embeddability, where mechanics and buckling play a decisive role. We also propose a non-axisymmetric actuation strategy to accomplish large amplitude bending and twisting motions of elongated cylindrical surfaces. Besides helping understand how euglenids delicately control their shape, our results may provide the background to engineer soft machines. PB - Elsevier UR - http://urania.sissa.it/xmlui/handle/1963/35118 U1 - 35375 U2 - Mathematics U4 - 1 ER - TY - JOUR T1 - A uniqueness result for the continuity equation in two dimensions: dedicated to constantine dafermos on the occasion of his 70th birthday Y1 - 2014 A1 - Giovanni Alberti A1 - Stefano Bianchini A1 - Gianluca Crippa AB - We characterize the autonomous, divergence-free vector fields b on the plane such that the Cauchy problem for the continuity equation ∂tu +div(bu) = 0 admits a unique bounded solution (in the weak sense) for every bounded initial datum; the characterization is given in terms of a property of Sard type for the potential f associated to b. As a corollary we obtain uniqueness under the assumption that the curl of b is a measure. This result can be extended to certain nonautonomous vector fields b with bounded divergence. PB - European Mathematical Society; Springer Verlag UR - http://urania.sissa.it/xmlui/handle/1963/34692 U1 - 34906 U2 - Mathematics U4 - 1 ER - TY - RPRT T1 - Attainment results for nematic elastomers Y1 - 2013 A1 - Virginia Agostiniani A1 - Gianni Dal Maso A1 - Antonio DeSimone AB - We consider a class of non-quasiconvex frame indifferent energy densities which includes Ogden-type energy densities for nematic elastomers. For the corresponding geometrically linear problem we provide an explicit minimizer of the energy functional satisfying a nontrivial boundary condition. Other attainment results, both for the nonlinear and the linearized model, are obtained by using the theory of convex integration introduced by Mueller and Sverak in the context of crystalline solids. PB - SISSA UR - http://hdl.handle.net/1963/7174 U1 - 7201 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - JOUR T1 - Common dynamical features of sensory adaptation in photoreceptors and olfactory sensory neurons. JF - Nature. Scientific Reports 3, Article number: 1251, Published : 13 February 2013 Y1 - 2013 A1 - Giovanna De Palo A1 - Giuseppe Facchetti A1 - Monica Mazzolini A1 - Anna Menini A1 - Vincent Torre A1 - Claudio Altafini AB -Sensory systems adapt, i.e., they adjust their sensitivity to external stimuli according to the ambient level. In this paper we show that single cell electrophysiological responses of vertebrate olfactory receptors and of photoreceptors to different input protocols exhibit several common features related to adaptation, and that these features can be used to investigate the dynamical structure of the feedback regulation responsible for the adaptation. In particular, we point out that two different forms of adaptation can be observed, in response to steps and to pairs of pulses. These two forms of adaptation appear to be in a dynamical trade-off: the more adaptation to a step is close to perfect, the slower is the recovery in adaptation to pulse pairs and viceversa. Neither of the two forms is explained by the dynamical models currently used to describe adaptation, such as the integral feedback model.

PB - SISSA U1 - 6453 U2 - Mathematics U4 - 1 ER - TY - RPRT T1 - The curvature: a variational approach Y1 - 2013 A1 - Andrei A. Agrachev A1 - Davide Barilari A1 - Luca Rizzi KW - Crurvature, subriemannian metric, optimal control problem AB - The curvature discussed in this paper is a rather far going generalization of the Riemannian sectional curvature. We define it for a wide class of optimal control problems: a unified framework including geometric structures such as Riemannian, sub-Riemannian, Finsler and sub-Finsler structures; a special attention is paid to the sub-Riemannian (or Carnot-Caratheodory) metric spaces. Our construction of the curvature is direct and naive, and it is similar to the original approach of Riemann. Surprisingly, it works in a very general setting and, in particular, for all sub-Riemannian spaces. PB - SISSA UR - http://hdl.handle.net/1963/7226 N1 - 88 pages, 10 figures, (v2) minor typos corrected, (v3) added sections on Finsler manifolds, slow growth distributions, Heisenberg group U1 - 7260 U2 - Mathematics U4 - 1 U5 - MAT/03 GEOMETRIA ER - TY - JOUR T1 - Early phase of plasticity-related gene regulation and SRF dependent transcription in the hippocampus JF - PloS one. Volume 8, Issue 7, July 2013 : e68078 Y1 - 2013 A1 - Giovanni Iacono A1 - Claudio Altafini A1 - Vincent Torre AB - Hippocampal organotypic cultures are a highly reliable in vitro model for studying neuroplasticity: in this paper, we analyze the early phase of the transcriptional response induced by a 20 µM gabazine treatment (GabT), a GABA-Ar antagonist, by using Affymetrix oligonucleotide microarray, RT-PCR based time-course and chromatin-immuno-precipitation. The transcriptome profiling revealed that the pool of genes up-regulated by GabT, besides being strongly related to the regulation of growth and synaptic transmission, is also endowed with neuro-protective and pro-survival properties. By using RT-PCR, we quantified a time-course of the transient expression for 33 of the highest up-regulated genes, with an average sampling rate of 10 minutes and covering the time interval [10:90] minutes. The cluster analysis of the time-course disclosed the existence of three different dynamical patterns, one of which proved, in a statistical analysis based on results from previous works, to be significantly related with SRF-dependent regulation (p-value<0.05). The chromatin immunoprecipitation (chip) assay confirmed the rich presence of working CArG boxes in the genes belonging to the latter dynamical pattern and therefore validated the statistical analysis. Furthermore, an in silico analysis of the promoters revealed the presence of additional conserved CArG boxes upstream of the genes Nr4a1 and Rgs2. The chip assay confirmed a significant SRF signal in the Nr4a1 CArG box but not in the Rgs2 CArG box. PB - Public Library of Science UR - http://hdl.handle.net/1963/7287 N1 - The article is composed of 15 pages U1 - 7332 U2 - Neuroscience U4 - -1 ER - TY - JOUR T1 - Expanded degenerations and pairs JF - Communications in Algebra. Volume 41, Issue 6, May 2013, Pages 2346-2386 Y1 - 2013 A1 - Dan Abramovich A1 - Charles Cadman A1 - Barbara Fantechi A1 - Jonathan Wise KW - Expanded pairs AB - Since Jun Li's original definition, several other definitions of expanded pairs and expanded degenerations have appeared in the literature. We explain how these definitions are related and introduce several new variants and perspectives. Among these are the twisted expansions used by Abramovich and Fantechi as a basis for orbifold techniques in degeneation formulas. PB - Taylor and Francis UR - http://hdl.handle.net/1963/7383 N1 - This article is composed of 41 pages and is recorded in PDF format U1 - 7431 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - RPRT T1 - Minimal partitions and image classification using a gradient-free perimeter approximation Y1 - 2013 A1 - Samuel Amstutz A1 - Nicolas Van Goethem A1 - Antonio André Novotny KW - Image classification, deblurring, optimal partitions, perimeter approximation AB - In this paper a new mathematically-founded method for the optimal partitioning of domains, with applications to the classification of greyscale and color images, is proposed. Since optimal partition problems are in general ill-posed, some regularization strategy is required. Here we regularize by a non-standard approximation of the total interface length, which does not involve the gradient of approximate characteristic functions, in contrast to the classical Modica-Mortola approximation. Instead, it involves a system of uncoupled linear partial differential equations and nevertheless shows $\Gamma$-convergence properties in appropriate function spaces. This approach leads to an alternating algorithm that ensures a decrease of the objective function at each iteration, and which always provides a partition, even during the iterations. The efficiency of this algorithm is illustrated by various numerical examples. Among them we consider binary and multilabel minimal partition problems including supervised or automatic image classification, inpainting, texture pattern identification and deblurring. PB - SISSA UR - http://hdl.handle.net/1963/6976 U1 - 6964 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - JOUR T1 - The nonlinear multidomain model: a new formal asymptotic analysis. JF - Geometry Partial Differential Equations – proceedings, CRM Series (15), 2013. Y1 - 2013 A1 - Stefano Amato A1 - Giovanni Bellettini A1 - Maurizio Paolini KW - bidomain model, anisotropic mean curvature, star-shaped combination AB -We study the asymptotic analysis of a singularly perturbed weakly parabolic system of m- equations of anisotropic reaction-diffusion type. Our main result formally shows that solutions to the system approximate a geometric motion of a hypersurface by anisotropic mean curvature. The anisotropy, supposed to be uniformly convex, is explicit and turns out to be the dual of the star-shaped combination of the m original anisotropies.

SN - 8876424724 U1 - 7259 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - JOUR T1 - Quadratic cohomology Y1 - 2013 A1 - Andrei A. Agrachev AB - We study homological invariants of smooth families of real quadratic forms as\r\na step towards a \"Lagrange multipliers rule in the large\" that intends to\r\ndescribe topology of smooth vector functions in terms of scalar Lagrange\r\nfunctions. PB - SISSA N1 - 24 pages U1 - 6456 U2 - Mathematics U4 - 1 U5 - MAT/03 GEOMETRIA ER - TY - JOUR T1 - Some open problems Y1 - 2013 A1 - Andrei A. Agrachev KW - Geometry AB - We discuss some challenging open problems in the geometric control theory and sub-Riemannian geometry. PB - SISSA UR - http://hdl.handle.net/1963/7070 U1 - 7064 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - JOUR T1 - Stabilization of Stochastic Quantum Dynamics via Open and Closed Loop Control JF - IEEE Transactions on Automatic Control. Volume 58, Issue 1, 2013, Article number6228517, Pages 74-85 Y1 - 2013 A1 - Claudio Altafini A1 - Francesco Ticozzi A1 - K. Nishio AB - In this paper, we investigate parametrization-free solutions of the problem of quantum pure state preparation and subspace stabilization by means of Hamiltonian control, continuous measurement, and quantum feedback, in the presence of a Markovian environment. In particular, we show that whenever suitable dissipative effects are induced either by the unmonitored environment, or by non-Hermitian measurements, there is no need for feedback, as open-loop time-invariant control is sufficient to achieve stabilization of the target set in probability. Constructive necessary and sufficient conditions on the form of the control Hamiltonian can be provided in this case. When time-invariant control is not sufficient, state stabilization can be attained by the addition of filtering-based feedback control UR - http://hdl.handle.net/1963/6503 U1 - 6448 U2 - Mathematics U4 - 1 ER - TY - THES T1 - Topology of moduli spaces of framed sheaves Y1 - 2013 A1 - Gharchia Abdellaoui KW - Moduli spaces, framed sheaves, instantons PB - SISSA UR - http://hdl.handle.net/1963/7152 U1 - 7158 U2 - Mathematics U4 - 1 U5 - MAT/03 GEOMETRIA ER - TY - CHAP T1 - Computing optimal strokes for low reynolds number swimmers T2 - Natural locomotion in fluids and on surfaces : swimming, flying, and sliding / editors Stephen Childress, Anette Hosoi, William W. Schultz, and Z. Jane Wang, editors, Y1 - 2012 A1 - Antonio DeSimone A1 - Luca Heltai A1 - François Alouges A1 - Lefebvre-Lepot Aline KW - Numerical analysis. AB -We discuss connections between low-Reynolds-number swimming and geometric control theory, and present a general algorithm for the numerical computation of energetically optimal strokes. As an illustration of our approach, we show computed motility maps and optimal strokes for two model swimmers.

JF - Natural locomotion in fluids and on surfaces : swimming, flying, and sliding / editors Stephen Childress, Anette Hosoi, William W. Schultz, and Z. Jane Wang, editors, PB - Springer SN - 9781461439967 UR - http://hdl.handle.net/1963/6445 U1 - 6381 U2 - Mathematics U4 - 1 U5 - MAT/08 ANALISI NUMERICA ER - TY - JOUR T1 - Decompositions of large-scale biological systems based on dynamical properties JF - Bioinformatics (Oxford, England). 2012 Jan; 28(1):76-83 Y1 - 2012 A1 - Nicola Soranzo A1 - Fahimeh Ramezani A1 - Giovanni Iacono A1 - Claudio Altafini AB - MOTIVATION: Given a large-scale biological network represented as an influence graph, in this article we investigate possible decompositions of the network aimed at highlighting specific dynamical properties.\\r\\nRESULTS: The first decomposition we study consists in finding a maximal directed acyclic subgraph of the network, which dynamically corresponds to searching for a maximal open-loop subsystem of the given system. Another dynamical property investigated is strong monotonicity. We propose two methods to deal with this property, both aimed at decomposing the system into strongly monotone subsystems, but with different structural characteristics: one method tends to produce a single large strongly monotone component, while the other typically generates a set of smaller disjoint strongly monotone subsystems.\\r\\nAVAILABILITY: Original heuristics for the methods investigated are described in the article. PB - Oxford University Press UR - http://hdl.handle.net/1963/5226 U1 - 5049 U2 - Physics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - Deformed Lorentz symmetry and relative locality in a curved/expanding spacetime JF - Phys. Rev. D 86 (2012) 124035 Y1 - 2012 A1 - Giovanni Amelino-Camelia A1 - Antonino Marciano A1 - Marco Matassa A1 - Giacomo Rosati KW - Doubly special relativity AB - The interest of part of the quantum-gravity community in the possibility of\r\nPlanck-scale-deformed Lorentz symmetry is also fueled by the opportunities for testing the relevant scenarios with analyses, from a signal-propagation perspective, of observations of bursts of particles from cosmological distances. In this respect the fact that so far the implications of deformed Lorentz symmetry have been investigated only for flat (Minkowskian) spacetimes represents a very significant limitation, since for propagation over cosmological distances the curvature/expansion of spacetime is evidently tangible. We here provide a significant step toward filling this gap by exhibiting an explicit example of Planck-scale-deformed relativistic symmetries of a spacetime with constant rate of expansion (deSitterian). Technically we obtain the first ever example of a relativistic theory of worldlines of particles with 3 nontrivial relativistic invariants: a large speed scale (\"speed-of-light scale\"), a large distance scale (inverse of the \"expansion-rate scale\"), and a large momentum scale (\"Planck scale\"). We address some of the challenges that had obstructed success for previous attempts by exploiting the recent understanding of the connection between deformed Lorentz symmetry and relativity of spacetime locality. We also offer a preliminary analysis of the differences between the scenario we here propose and the most studied scenario for broken (rather than deformed) Lorentz symmetry in expanding spacetimes. PB - American Physical Society N1 - 12 pages, 5 figures U1 - 6496 U2 - Physics U4 - -1 ER - TY - JOUR T1 - Detection of transcriptional triggers in the dynamics of microbial growth: application to the respiratory-versatile bacterium Shewanella oneidensis JF - Nucleic Acids Research, Volume 40, Issue 15, August 2012, Pages 7132-7149 Y1 - 2012 A1 - Q Beg A1 - Mattia Zampieri A1 - N Klitgord A1 - S Collins A1 - M Serres A1 - Daniel Segrè A1 - Claudio Altafini AB - The capacity of microorganisms to respond to variable external conditions requires a coordination of environment-sensing mechanisms and decisionmaking regulatory circuits. Here, we seek to understand the interplay between these two processes by combining high-throughput measurement of time-dependent mRNA profiles with a novel computational approach that searches for key genetic triggers of transcriptional changes. Our approach helped us understand the regulatory strategies of a respiratorily versatile bacterium with promising bioenergy and bioremediation applications, Shewanella oneidensis, in minimal and rich media. By comparing expression profiles across these two conditions, we unveiled components of the transcriptional program that depend mainly on the growth phase. Conversely, by integrating our time-dependent data with a previously available large compendium of static perturbation responses, we identified transcriptional changes that cannot be explained solely by internal network dynamics, but are rather triggered by specific genes acting as key mediators of an environment-dependent response. These transcriptional triggers include known and novel regulators that respond to carbon, nitrogen and oxygen limitation. Our analysis suggests a sequence of physiological responses, including a coupling between nitrogen depletion and glycogen storage, partially recapitulated through dynamic flux balance analysis, and experimentally confirmed by metabolite measurements. Our approach is broadly applicable to other systems PB - SISSA UR - http://hdl.handle.net/1963/6506 U1 - 6452 U2 - Mathematics U4 - 1 ER - TY - JOUR T1 - A dynamical feedback model for adaptation in the olfactory transduction pathway JF - Biophysical Journal. Volume 102, Issue 12, 20 June 2012, Pages 2677-2686 Y1 - 2012 A1 - Giovanna De Palo A1 - Anna Boccaccio A1 - Andrew Miri A1 - Anna Menini A1 - Claudio Altafini AB - Olfactory transduction exhibits two distinct types of adaptation, which we denote multipulse and step adaptation. In terms of measured transduction current, multipulse adaptation appears as a decrease in the amplitude of the second of two consecutive responses when the olfactory neuron is stimulated with two brief pulses. Step adaptation occurs in response to a sustained steplike stimulation and is characterized by a return to a steady-state current amplitude close to the prestimulus value, after a transient peak. In this article, we formulate a dynamical model of the olfactory transduction pathway, which includes the kinetics of the CNG channels, the concentration of Ca ions flowing through them, and the Ca-complexes responsible for the regulation. Based on this model, a common dynamical explanation for the two types of adaptation is suggested. We show that both forms of adaptation can be well described using different time constants for the kinetics of Ca ions (faster) and the kinetics of the feedback mechanisms (slower). The model is validated on experimental data collected in voltage-clamp conditions using different techniques and animal species. PB - Biophysical Society, Elsevier UR - http://hdl.handle.net/1963/7019 U1 - 7012 U2 - Neuroscience U4 - -1 ER - TY - JOUR T1 - Dynamics of opinion forming in structurally balanced social networks JF - PloS one. 2012 ; 7(6):e38135 Y1 - 2012 A1 - Claudio Altafini AB - A structurally balanced social network is a social community that splits into two antagonistic factions (typical example being a two-party political system). The process of opinion forming on such a community is most often highly predictable, with polarized opinions reflecting the bipartition of the network. The aim of this paper is to suggest a class of dynamical systems, called monotone systems, as natural models for the dynamics of opinion forming on structurally balanced social networks. The high predictability of the outcome of a decision process is explained in terms of the order-preserving character of the solutions of this class of dynamical systems. If we represent a social network as a signed graph in which individuals are the nodes and the signs of the edges represent friendly or hostile relationships, then the property of structural balance corresponds to the social community being splittable into two antagonistic factions, each containing only friends. PB - PLoS UR - http://hdl.handle.net/1963/6051 U1 - 5942 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - Exploring the low-energy landscape of large-scale signed social networks JF - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. Volume 86, Issue 3, 26 September 2012, Article number036116 Y1 - 2012 A1 - Giuseppe Facchetti A1 - Giovanni Iacono A1 - Claudio Altafini AB - Analogously to a spin glass, a large-scale signed social network is characterized by the presence of disorder, expressed in this context (and in the social network literature) by the concept of structural balance. If, as we have recently shown, the signed social networks currently available have a limited amount of true disorder (or frustration), it is also interesting to investigate how this frustration is organized, by exploring the landscape of near-optimal structural balance. What we obtain in this paper is that while one of the networks analyzed shows a unique valley of minima, and a funneled landscape that gradually and smoothly worsens as we move away from the optimum, another network shows instead several distinct valleys of optimal or near-optimal structural balance, separated by energy barriers determined by internally balanced subcommunities of users, a phenomenon similar to the replica-symmetry breaking of spin glasses. Multiple, essentially isoenergetic, arrangements of these communities are possible. Passing from one valley to another requires one to destroy the internal arrangement of these balanced subcommunities and then to reform it again. It is essentially this process of breaking the internal balance of the subcommunities which gives rise to the energy barriers. PB - SISSA UR - http://hdl.handle.net/1963/6504 U1 - 6451 U2 - Mathematics U4 - 1 ER - TY - JOUR T1 - Gamma-convergence and H-convergence of linear elliptic operators JF - Journal de Mathématiques Pures et Appliquées, Available online 12 September 2012 Y1 - 2012 A1 - Nadia Ansini A1 - Gianni Dal Maso A1 - Caterina Ida Zeppieri KW - Linear elliptic operators PB - Elsevier UR - http://hdl.handle.net/1963/5878 U1 - 5746 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - On the Hausdorff volume in sub-Riemannian geometry JF - Calculus of Variations and Partial Differential Equations. Volume 43, Issue 3-4, March 2012, Pages 355-388 Y1 - 2012 A1 - Andrei A. Agrachev A1 - Davide Barilari A1 - Ugo Boscain AB - For a regular sub-Riemannian manifold we study the Radon-Nikodym derivative\r\nof the spherical Hausdorff measure with respect to a smooth volume. We prove\r\nthat this is the volume of the unit ball in the nilpotent approximation and it\r\nis always a continuous function. We then prove that up to dimension 4 it is\r\nsmooth, while starting from dimension 5, in corank 1 case, it is C^3 (and C^4\r\non every smooth curve) but in general not C^5. These results answer to a\r\nquestion addressed by Montgomery about the relation between two intrinsic\r\nvolumes that can be defined in a sub-Riemannian manifold, namely the Popp and\r\nthe Hausdorff volume. If the nilpotent approximation depends on the point (that\r\nmay happen starting from dimension 5), then they are not proportional, in\r\ngeneral. PB - SISSA UR - http://hdl.handle.net/1963/6454 U1 - 6399 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - RPRT T1 - Introduction to Riemannian and sub-Riemannian geometry Y1 - 2012 A1 - Andrei A. Agrachev A1 - Davide Barilari A1 - Ugo Boscain PB - SISSA UR - http://hdl.handle.net/1963/5877 U1 - 5747 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - Linear elasticity obtained from finite elasticity by Gamma-convergence under weak coerciveness conditions JF - Ann. Inst. H. Poincare Anal. Non Lineaire Y1 - 2012 A1 - Virginia Agostiniani A1 - Gianni Dal Maso A1 - Antonio DeSimone KW - Nonlinear elasticity AB -The energy functional of linear elasticity is obtained as G-limit of suitable rescalings of the energies of finite elasticity...

PB - Gauthier-Villars;Elsevier VL - 29 UR - http://hdl.handle.net/1963/4267 U1 - 3996 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - Modeling and control of quantum systems: An introduction JF - IEEE Transactions on Automatic Control. Volume 57, Issue 8, 2012, Article number6189035, Pages 1898-1917 Y1 - 2012 A1 - Claudio Altafini A1 - Francesco Ticozzi AB - The scope of this work is to provide a self-contained introduction to a selection of basic theoretical aspects in the modeling and control of quantum mechanical systems, as well as a brief survey on the main approaches to control synthesis. While part of the existing theory, especially in the open-loop setting, stems directly from classical control theory (most notably geometric control and optimal control), a number of tools specifically tailored for quantum systems have been developed since the 1980s, in order to take into account their distinctive features: the probabilistic nature of atomic-scale physical systems, the effect of dissipation and the irreversible character of the measurements have all proved to be critical in feedback-design problems. The relevant dynamical models for both closed and open quantum systems are presented, along with the main results on their controllability and stability. A brief review of several currently available control design methods is meant to provide the interested reader with a roadmap for further studies PB - Institute of Electrical and Electronics Engineers UR - http://hdl.handle.net/1963/6505 U1 - 6449 U2 - Mathematics U4 - 1 ER - TY - JOUR T1 - Ogden-type energies for nematic elastomers JF - International Journal of Non-Linear mechanics Y1 - 2012 A1 - Virginia Agostiniani A1 - Antonio DeSimone KW - Nonlinear elasticity AB -Ogden-type extensions of the free-energy densities currently used to model the mechanical behavior of nematic elastomers are proposed and analyzed. Based on a multiplicative decomposition of the deformation gradient into an elastic and a spontaneous or remanent part, they provide a suitable framework to study the stiffening response at high imposed stretches. Geometrically linear versions of the models (Taylor expansions at order two) are provided and discussed. These small strain theories provide a clear illustration of the geometric structure of the underlying energy landscape (the energy grows quadratically with the distance from a non-convex set of spontaneous strains or energy wells). The comparison between small strain and finite deformation theories may also be useful in the opposite direction, inspiring finite deformation generalizations of small strain theories currently used in the mechanics of active and phase-transforming materials. The energy well structure makes the free-energy densities non-convex. Explicit quasi-convex envelopes are provided, and applied to compute the stiffening response of a specimen tested in plane strain extension experiments (pure shear).

PB - Elsevier VL - 47 IS - 2 U1 - 6971 U2 - Mathematics U4 - -1 ER - TY - JOUR T1 - Predicting and characterizing selective multiple drug treatments for metabolic diseases and cancer. JF - BMC Systems Biology. 29 August 2012, Page 115 Y1 - 2012 A1 - Giuseppe Facchetti A1 - Claudio Altafini A1 - Mattia Zampieri AB - Background: In the field of drug discovery, assessing the potential of multidrug therapies is a difficult task because of the combinatorial complexity (both theoretical and experimental) and because of the requirements on the selectivity of the therapy. To cope with this problem, we have developed a novel method for the systematic in silico investigation of synergistic effects of currently available drugs on genome-scale metabolic networks. The algorithm finds the optimal combination of drugs which guarantees the inhibition of an objective function, while minimizing the side effect on the overall network. Results: Two different applications are considered: finding drug synergisms for human metabolic diseases (like diabetes, obesity and hypertension) and finding antitumoral drug combinations with minimal side effect on the normal human metabolism.The results we obtain are consistent with some of the available therapeutic indications and predict some new multiple drug treatments.A cluster analysis on all possible interactions among the currently available drugs indicates a limited variety on the metabolic targets for the approved drugs. Conclusion: The in silico prediction of drug synergism can represent an important tool for the repurposing of drug in a realistic perspective which considers also the selectivty of the therapy. Moreover, for a more profitable exploitation of drug-drug interactions, also drugs which show a too low efficacy but which have a non-common mechanism of action, can be reconsider as potential ingredients of new multicompound therapeutic indications.Needless to say the clues provided by a computational study like ours need in any case to be thoroughly evaluated experimentally. PB - BioMed Central UR - http://hdl.handle.net/1963/6515 U1 - 6450 U2 - Mathematics U4 - 1 ER - TY - JOUR T1 - Reverse engineering the euglenoid movement JF - Proceedings of the National Academy of Sciences of the United States of America. Volume 109, Issue 44, 30 October 2012, Pages 17874-17879 Y1 - 2012 A1 - Marino Arroyo A1 - Luca Heltai A1 - Daniel Millán A1 - Antonio DeSimone KW - microswimmers AB - Euglenids exhibit an unconventional motility strategy amongst unicellular eukaryotes, consisting of large-amplitude highly concerted deformations of the entire body (euglenoid movement or metaboly). A plastic cell envelope called pellicle mediates these deformations. Unlike ciliary or flagellar motility, the biophysics of this mode is not well understood, including its efficiency and molecular machinery. We quantitatively examine video recordings of four euglenids executing such motions with statistical learning methods. This analysis reveals strokes of high uniformity in shape and pace. We then interpret the observations in the light of a theory for the pellicle kinematics, providing a precise understanding of the link between local actuation by pellicle shear and shape control. We systematically understand common observations, such as the helical conformations of the pellicle, and identify previously unnoticed features of metaboly. While two of our euglenids execute their stroke at constant body volume, the other two exhibit deviations of about 20% from their average volume, challenging current models of low Reynolds number locomotion. We find that the active pellicle shear deformations causing shape changes can reach 340%, and estimate the velocity of the molecular motors. Moreover, we find that metaboly accomplishes locomotion at hydrodynamic efficiencies comparable to those of ciliates and flagellates. Our results suggest new quantitative experiments, provide insight into the evolutionary history of euglenids, and suggest that the pellicle may serve as a model for engineered active surfaces with applications in microfluidics. UR - http://hdl.handle.net/1963/6444 U1 - 6380 U2 - Mathematics U4 - 1 U5 - MAT/08 ANALISI NUMERICA ER - TY - JOUR T1 - On robust Lie-algebraic stability conditions for switched linear systems JF - Systems and Control Letters. Volume 61, Issue 2, February 2012, Pages 347-353 Y1 - 2012 A1 - Andrei A. Agrachev A1 - Yurij Baryshnikov A1 - Daniel Liberzon AB - This paper presents new sufficient conditions for exponential stability of switched linear systems under arbitrary switching, which involve the commutators (Lie brackets) among the given matrices generating the switched system. The main novelty feature of these stability criteria is that, unlike their earlier counterparts, they are robust with respect to small perturbations of the system parameters. UR - http://hdl.handle.net/1963/6455 U1 - 6400 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - JOUR T1 - Second order approximations of quasistatic evolution problems in finite dimension JF - Discrete & Continuous Dynamical Systems - A Y1 - 2012 A1 - Virginia Agostiniani KW - discrete approximations KW - perturbation methods KW - saddle-node bifurcation KW - Singular perturbations KW - vanishing viscosity AB -In this paper, we study the limit, as ε goes to zero, of a particular solution of the equation $\epsilon^2A\ddot u^ε(t)+εB\dot u^ε(t)+\nabla_xf(t,u^ε(t))=0$, where $f(t,x)$ is a potential satisfying suitable coerciveness conditions. The limit $u(t)$ of $u^ε(t)$ is piece-wise continuous and verifies $\nabla_xf(t,u(t))=0$. Moreover, certain jump conditions characterize the behaviour of $u(t)$ at the discontinuity times. The same limit behaviour is obtained by considering a different approximation scheme based on time discretization and on the solutions of suitable autonomous systems.

VL - 32 UR - http://aimsciences.org//article/id/560b82d9-f289-498a-a619-a4b132aaf9f8 ER - TY - JOUR T1 - Sub-Riemannian structures on 3D Lie groups JF - Journal of Dynamical and Control Systems. Volume 18, Issue 1, January 2012, Pages 21-44 Y1 - 2012 A1 - Andrei A. Agrachev A1 - Davide Barilari AB -We give a complete classification of left-invariant sub-Riemannian structures on three dimensional Lie groups in terms of the basic differential invariants. As a corollary we explicitly find a sub-Riemannian isometry between the nonisomorphic Lie groups $SL(2)$ and $A^+(\mathbb{R})\times S^1$, where $A^+(\mathbb{R})$ denotes the group of orientation preserving affine maps on the real line.

PB - SISSA UR - http://hdl.handle.net/1963/6453 U1 - 6397 U2 - Mathematics U4 - 1 U5 - MAT/03 GEOMETRIA ER - TY - JOUR T1 - Systems of Quadratic Inequalities JF - Proceedings of the London Mathematical Society, Volume 105, Issue 3, September 2012, Pages 622-660 Y1 - 2012 A1 - Andrei A. Agrachev A1 - Antonio Lerario AB - We present a spectral sequence which efficiently computes Betti numbers of a closed semi-algebraic subset of RP^n defined by a system of quadratic inequalities and the image of the homology homomorphism induced by the inclusion of this subset in RP^n. We do not restrict ourselves to the term E_2 of the spectral sequence and give a simple explicit formula for the differential d_2. PB - SISSA UR - http://hdl.handle.net/1963/7072 U1 - 7066 U2 - Mathematics U4 - 1 U5 - MAT/03 GEOMETRIA ER - TY - RPRT T1 - Topological sensitivity analysis for high order elliptic operators Y1 - 2012 A1 - Samuel Amstutz A1 - Antonio André Novotny A1 - Nicolas Van Goethem KW - Topological derivative, Elliptic operators, Polarization tensor AB - The topological derivative is defined as the first term of the asymptotic expansion of a given shape functional with respect to a small parameter that measures the size of a singular domain perturbation. It has applications in many different fields such as shape and topology optimization, inverse problems, image processing and mechanical modeling including synthesis and/or optimal design of microstructures, fracture mechanics sensitivity analysis and damage evolution modeling. The topological derivative has been fully developed for a wide range of second order differential operators. In this paper we deal with the topological asymptotic expansion of a class of shape functionals associated with elliptic differential operators of order 2m, m>=1. The general structure of the polarization tensor is derived and the concept of degenerate polarization tensor is introduced. We provide full mathematical justifications for the derived formulas, including precise estimates of remainders. PB - SISSA UR - http://hdl.handle.net/1963/6343 U1 - 6272 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - JOUR T1 - Adaptation as a genome-wide autoregulatory principle in the stress response of yeast. JF - IET systems biology. 2011 Jul; 5(4):269-79 Y1 - 2011 A1 - F Eduati A1 - B Di Camillo A1 - G Toffolo A1 - Claudio Altafini A1 - Giovanna De Palo A1 - Mattia Zampieri AB - The gene expression response of yeast to various types of stresses/perturbations shows a common functional and dynamical pattern for the vast majority of genes, characterised by a quick transient peak (affecting primarily short genes) followed by a return to the pre-stimulus level. Kinetically, this process of adaptation following the transient excursion can be modelled using a genome-wide autoregulatory mechanism by means of which yeast aims at maintaining a preferential concentration in its mRNA levels. The resulting feedback system explains well the different time constants observable in the transient response, while being in agreement with all the known experimental dynamical features. For example, it suggests that a very rapid transient can be induced also by a slowly varying concentration of the gene products. PB - The Institution of Engineering and Technology UR - http://hdl.handle.net/1963/5106 U1 - 4922 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - Bishop and Laplacian Comparison Theorems on Three Dimensional Contact Subriemannian Manifolds with Symmetry Y1 - 2011 A1 - Andrei A. Agrachev A1 - Paul Lee AB - We prove a Bishop volume comparison theorem and a Laplacian comparison\r\ntheorem for three dimensional contact subriemannian manifolds with symmetry. PB - SISSA UR - http://hdl.handle.net/1963/6508 N1 - 25 pages U1 - 6455 U2 - Mathematics U4 - 1 ER - TY - JOUR T1 - Computing global structural balance in large-scale signed social networks. JF - Proceedings of the National Academy of Sciences of the United States of America. Volume 108, Issue 52, 27 December 2011, Pages 20953-20958 Y1 - 2011 A1 - Giuseppe Facchetti A1 - Giovanni Iacono A1 - Claudio Altafini KW - Combinatorial optimization AB - Structural balance theory affirms that signed social networks (i.e., graphs whose signed edges represent friendly/hostile interactions among individuals) tend to be organized so as to avoid conflictual situations, corresponding to cycles of negative parity. Using an algorithm for ground-state calculation in large-scale Ising spin glasses, in this paper we compute the global level of balance of very large online social networks and verify that currently available networks are indeed extremely balanced. This property is explainable in terms of the high degree of skewness of the sign distributions on the nodes of the graph. In particular, individuals linked by a large majority of negative edges create mostly \\\"apparent disorder,\\\" rather than true \\\"frustration.\\\" PB - National Academy of Sciences UR - http://hdl.handle.net/1963/6426 N1 - Free fulltext article in Pubmed Central U1 - 6362 U2 - Physics U4 - -1 ER - TY - JOUR T1 - Gamma-convergence of energies for nematic elastomers in the small strain limit JF - Continuum. Mech. Therm. Y1 - 2011 A1 - Virginia Agostiniani A1 - Antonio DeSimone KW - Liquid crystals AB -We study two variational models recently proposed in the literature to describe the mechanical behaviour of nematic elastomers either in the fully nonlinear regime or in the framework of a geometrically linear theory. We show that, in the small strain limit, the energy functional of the first one I\\\"-converges to the relaxation of the second one, a functional for which an explicit representation formula is available.

PB - Springer VL - 23 UR - http://hdl.handle.net/1963/4141 U1 - 3882 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - Generalized Ricci Curvature Bounds for Three Dimensional Contact Subriemannian manifolds Y1 - 2011 A1 - Andrei A. Agrachev A1 - Paul Lee PB - SISSA UR - http://hdl.handle.net/1963/6507 N1 - This is a revised extended version that contains new results. U1 - 6454 U2 - Mathematics U4 - 1 ER - TY - JOUR T1 - The geometry of Maximum Principle JF - Proceedings of the Steklov Institute of mathematics. vol. 273 (2011), page: 5-27 ; ISSN: 0081-5438 Y1 - 2011 A1 - Andrei A. Agrachev A1 - Revaz Gamkrelidze AB - An invariant formulation of the maximum principle in optimal control is presented, and some second-order invariants are discussed. UR - http://hdl.handle.net/1963/6456 U1 - 6401 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - JOUR T1 - Large Time Existence for Thin Vibrating Plates JF - Communication in Partial Differential Equations 36 (2011) 2062-2102 Y1 - 2011 A1 - Helmut Abels A1 - Maria Giovanna Mora A1 - Stefan Müller AB - We construct strong solutions for a nonlinear wave equation for a thin vibrating plate described by nonlinear elastodynamics. For sufficiently small thickness we obtain existence of strong solutions for large\\r\\ntimes under appropriate scaling of the initial values such that the limit system as h --> 0 is either the nonlinear von Karman plate equation or the linear fourth order Germain-Lagrange equation. In the case of the\\r\\nlinear Germain-Lagrange equation we even obtain a convergence rate of the three-dimensional solution to the solution of the two-dimensional linear plate equation. PB - Taylor & Francis UR - http://hdl.handle.net/1963/3755 U1 - 562 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Numerical Strategies for Stroke Optimization of Axisymmetric Microswimmers JF - Mathematical Models and Methods in Applied Sciences 21 (2011) 361-387 Y1 - 2011 A1 - François Alouges A1 - Antonio DeSimone A1 - Luca Heltai KW - Optimal swimming AB - We propose a computational method to solve optimal swimming problems, based on the boundary integral formulation of the hydrodynamic interaction between swimmer and surrounding fluid and direct constrained minimization of the energy consumed by the swimmer. We apply our method to axisymmetric model examples. We consider a classical model swimmer (the three-sphere swimmer of Golestanian et al.) as well as a novel axisymmetric swimmer inspired by the observation of biological micro-organisms. PB - World Scientific UR - http://hdl.handle.net/1963/3657 U1 - 648 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Osservazioni sui teoremi di inversione globale JF - Rendiconti Lincei - Matematica e Applicazioni 22 (2011) 3-15 Y1 - 2011 A1 - Antonio Ambrosetti AB - Some global inversion theorems with applications to semilinear elliptic equation are discussed. PB - European Mathematical Society UR - http://hdl.handle.net/1963/4068 U1 - 334 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Quasistatic evolution of sessile drops and contact angle hysteresis JF - Arch. Rational Mech. Anal. 202 (2011) 295-348 Y1 - 2011 A1 - Giovanni Alberti A1 - Antonio DeSimone AB - We consider the classical model of capillarity coupled with a rate-independent dissipation mechanism due to frictional forces acting on the contact line, and prove the existence of quasistatic evolutions with prescribed initial configuration. We also discuss in detail some explicit solutions to show that the model does account for contact angle hysteresis, and to compare its predictions with experimental observations. PB - Springer UR - http://hdl.handle.net/1963/4912 U1 - 4693 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - On the Space of Symmetric Operators with Multiple Ground States JF - Functional Analysis and its Applications, Volume 45, Issue 4, December 2011, Pages 241-251 Y1 - 2011 A1 - Andrei A. Agrachev KW - Multiple eigenvalue AB - We study homological structure of the filtrations of the spaces of self-adjoint operators by the multiplicity of the ground state. We consider only operators acting in a finite dimensional complex or real Hilbert space but infinite dimensional generalizations are easily guessed. PB - SISSA UR - http://hdl.handle.net/1963/7069 U1 - 6392 U2 - Mathematics U4 - 1 U5 - MAT/03 GEOMETRIA ER - TY - RPRT T1 - Structure of level sets and Sard-type properties of Lipschitz maps Y1 - 2011 A1 - Giovanni Alberti A1 - Stefano Bianchini A1 - Gianluca Crippa PB - SISSA UR - http://hdl.handle.net/1963/4657 U1 - 4424 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - A system-level approach for deciphering the transcriptional response to prion infection JF - Bioinformatics (Oxford, England). 2011 Dec; 27(24):3407-14 Y1 - 2011 A1 - Mattia Zampieri A1 - Giuseppe Legname A1 - Daniel Segrè A1 - Claudio Altafini AB - MOTIVATION: Deciphering the response of a complex biological system to an insulting event, at the gene expression level, requires adopting theoretical models that are more sophisticated than a one-to-one comparison (i.e. t-test). Here, we investigate the ability of a novel reverse engineering approach (System Response Inference) to unveil non-obvious transcriptional signatures of the system response induced by prion infection.\\r\\nRESULTS: To this end, we analyze previously published gene expression data, from which we extrapolate a putative full-scale model of transcriptional gene-gene dependencies in the mouse central nervous system. Then, we use this nominal model to interpret the gene expression changes caused by prion replication, aiming at selecting the genes primarily influenced by this perturbation. Our method sheds light on the mode of action of prions by identifying key transcripts that are the most likely to be responsible for the overall transcriptional rearrangement from a nominal regulatory network. As a first result of our inference, we have been able to predict known targets of prions (i.e. PrP(C)) and to unveil the potential role of previously unsuspected genes.\\r\\nCONTACT: altafini@sissa.it\\r\\nSUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. PB - Oxford University Press UR - http://hdl.handle.net/1963/5745 U1 - 5600 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - The time-dependent von Kármán plate equation as a limit of 3d nonlinear elasticity JF - Calculus of Variations and Partial Differential Equations 41 (2011) 241-259 Y1 - 2011 A1 - Helmut Abels A1 - Maria Giovanna Mora A1 - Stefan Müller AB - The asymptotic behaviour of the solutions of three-dimensional nonlinear elastodynamics in a thin plate is studied, as the thickness $h$ of the plate tends to zero. Under appropriate scalings of the applied force and of the initial values in terms of $h$, it is shown that three-dimensional solutions of the nonlinear elastodynamic equation converge to solutions of the time-dependent von K\\\\\\\'arm\\\\\\\'an plate equation. PB - Springer UR - http://hdl.handle.net/1963/3835 U1 - 492 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - RPRT T1 - A uniqueness result for the continuity equation in two dimensions Y1 - 2011 A1 - Giovanni Alberti A1 - Stefano Bianchini A1 - Gianluca Crippa PB - SISSA UR - http://hdl.handle.net/1963/4663 U1 - 4425 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - Continuity of optimal control costs and its application to weak KAM theory JF - Calculus of Variations and Partial Differential Equations. Volume 39, Issue 1, 2010, Pages 213-232 Y1 - 2010 A1 - Andrei A. Agrachev A1 - Paul Lee AB - We prove continuity of certain cost functions arising from optimal control of\\r\\naffine control systems. We give sharp sufficient conditions for this\\r\\ncontinuity. As an application, we prove a version of weak KAM theorem and\\r\\nconsider the Aubry-Mather problems corresponding to these systems. PB - SISSA UR - http://hdl.handle.net/1963/6459 N1 - 23 pages, 1 figures U1 - 6405 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - JOUR T1 - Dynamics control by a time-varying feedback JF - Journal of Dynamical and Control Systems. Volume 16, Issue 2, April 2010, Pages :149-162 Y1 - 2010 A1 - Andrei A. Agrachev A1 - Marco Caponigro KW - Discrete-time dynamics AB - We consider a smooth bracket generating control-affine system in R^d and show that any orientation preserving diffeomorphism of R^d can be approximated, in the very strong sense, by a diffeomorphism included in the flow generated by a time-varying feedback control which is polynomial with respect to the state variables and trigonometric-polynomial with respect to the time variable. PB - SISSA UR - http://hdl.handle.net/1963/6461 U1 - 6407 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - JOUR T1 - Feedback schemes for radiation damping suppression in NMR: a control-theoretical perspective JF - Systems and Control Letters, 59 (12):782-786, 2010 Y1 - 2010 A1 - Claudio Altafini A1 - Paola Cappellaro A1 - David Cory AB - In NMR spectroscopy, the collective measurement is weakly invasive and its back-action is called radiation damping. The aim of this paper is to provide a control-theoretical analysis of the problem of suppressing this radiation damping. It is shown that the two feedback schemes commonly used in the NMR practice correspond one to a high gain oputput feedback for the simple case of maintaining the spin 1/2 in its inverted state, and the second to a 2-degree of freedom control design with a prefeedback that exactly cancels the radiation damping field. A general high gain feedback stabilization design not requiring the knowledge of the radiation damping time constant is also investigated. PB - Elsevier UR - http://hdl.handle.net/1963/4384 U1 - 4132 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - Invariant Lagrange submanifolds of dissipative systems JF - Russian Mathematical Surveys. Volume 65, Issue 5, 2010, Pages: 977-978 Y1 - 2010 A1 - Andrei A. Agrachev AB - We study solutions of modified Hamilton-Jacobi equations H(du/dq,q) + cu(q) =\\r\\n0, q \\\\in M, on a compact manifold M . PB - SISSA UR - http://hdl.handle.net/1963/6457 U1 - 6403 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - JOUR T1 - A kinetic mechanism inducing oscillations in simple chemical reactions networks JF - Mathematical Biosciences and Engineering 7(2):301-312, 2010 Y1 - 2010 A1 - Julien Coatleven A1 - Claudio Altafini AB - It is known that a kinetic reaction network in which one or more secondary substrates are acting as cofactors may exhibit an oscillatory behavior. The aim of this work is to provide a description of the functional form of such a cofactor action guaranteeing the\\r\\nonset of oscillations in sufficiently simple reaction networks. PB - American Institute of Mathematical Sciences UR - http://hdl.handle.net/1963/2393 U1 - 2304 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Monotonicity, frustration, and ordered response: an analysis of the energy landscape of perturbed large-scale biological networks JF - BMC Systems Biology 2010, 4:83 Y1 - 2010 A1 - Giovanni Iacono A1 - Claudio Altafini AB - Background. \\nFor large-scale biological networks represented as signed graphs, the index of frustration measures how far a network is from a monotone system, i.e., how incoherently the system responds to perturbations.\\nResults. \\nIn this paper we find that the frustration is systematically lower in transcriptional networks (modeled at functional level) than in signaling and metabolic networks (modeled at stoichiometric level). A possible interpretation of this result is in terms of energetic cost of an interaction: an erroneous or contradictory transcriptional action costs much more than a signaling/metabolic error, and therefore must be avoided as much as possible. Averaging over all possible perturbations, however, we also find that unlike for transcriptional networks, in the signaling/metabolic networks the probability of finding the system in its least frustrated configuration tends to be high also in correspondence of a moderate energetic regime, meaning that, in spite of the higher frustration, these networks can achieve a globally ordered response to perturbations even for moderate values of the strength of the interactions. Furthermore, an analysis of the energy landscape shows that signaling and metabolic networks lack energetic barriers around their global optima, a property also favouring global order.\\nConclusion. \\nIn conclusion, transcriptional and signaling/metabolic networks appear to have systematic differences in both the index of frustration and the transition to global order. These differences are interpretable in terms of the different functions of the various classes of networks. PB - BioMed Central UR - http://hdl.handle.net/1963/4055 U1 - 347 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - RPRT T1 - On the number of positive solutions of some semilinear elliptic problems Y1 - 2010 A1 - Antonio Ambrosetti UR - http://hdl.handle.net/1963/4083 U1 - 320 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - RPRT T1 - Numerical Solution of the Small Dispersion Limit of the Camassa-Holm and Whitham Equations and Multiscale Expansions Y1 - 2010 A1 - Simonetta Abenda A1 - Tamara Grava A1 - Christian Klein AB - The small dispersion limit of solutions to the Camassa-Holm (CH) equation is characterized by the appearance of a zone of rapid modulated oscillations. An asymptotic description of these oscillations is given, for short times, by the one-phase solution to the CH equation, where the branch points of the corresponding elliptic curve depend on the physical coordinates via the Whitham equations. We present a conjecture for the phase of the asymptotic solution. A numerical study of this limit for smooth hump-like initial data provides strong evidence for the validity of this conjecture.... UR - http://hdl.handle.net/1963/3840 U1 - 487 U2 - Mathematics U3 - Mathematical Physics ER - TY - RPRT T1 - Optimally swimming Stokesian Robots Y1 - 2010 A1 - François Alouges A1 - Antonio DeSimone A1 - Luca Heltai A1 - Aline Lefebvre A1 - Benoit Merlet AB - We study self propelled stokesian robots composed of assemblies of balls, in dimen-\\nsions 2 and 3, and prove that they are able to control their position and orientation. This is a result of controllability, and its proof relies on applying Chow\\\'s theorem in an analytic framework, similarly to what has been done in [3] for an axisymmetric system swimming along the axis of symmetry. However, we simplify drastically\\nthe analyticity result given in [3] and apply it to a situation where more complex swimmers move either in a plane or in three-dimensional space, hence experiencing also rotations. We then focus our attention on energetically optimal strokes, which we are able to compute numerically. Some examples of computed optimal strokes are discussed in detail. UR - http://hdl.handle.net/1963/3929 U1 - 472 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - RPRT T1 - The role of membrane viscosity in the dynamics of fluid membranes Y1 - 2010 A1 - Marino Arroyo A1 - Antonio DeSimone A1 - Luca Heltai AB - Fluid membranes made out of lipid bilayers are the fundamental separation structure in eukaryotic cells. Many physiological processes rely on dramatic shape and topological changes (e.g. fusion, fission) of fluid membrane systems. Fluidity is key to the versatility and constant reorganization of lipid bilayers. Here, we study the role of the membrane intrinsic viscosity, arising from the friction of the lipid molecules as they rearrange to accommodate shape changes, in the dynamics of morphological changes of fluid vesicles. In particular, we analyze the competition between the membrane viscosity and the viscosity of the bulk fluid surrounding the vesicle as the dominant dissipative mechanism. We consider the relaxation dynamics of fluid vesicles put in an out-of-equilibrium state, but conclusions can be drawn regarding the kinetics or power consumption in regulated shape changes in the cell. On the basis of numerical calculations, we find that the dynamics arising from the membrane viscosity are qualitatively different from the dynamics arising from the bulk viscosity. When these two dissipation mechanisms are put in competition, we find that for small vesicles the membrane dissipation dominates, with a relaxation time that scales as the size of the vesicle to the power 2. For large vesicles, the bulk dissipation dominates, and the exponent in the relaxation time vs. size relation is 3. UR - http://hdl.handle.net/1963/3930 U1 - 471 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Two-dimensional almost-Riemannian structures with tangency points JF - Ann. Inst. H. Poincare Anal. Non Lineaire Y1 - 2010 A1 - Andrei A. Agrachev A1 - Ugo Boscain A1 - Grégoire Charlot A1 - Roberta Ghezzi A1 - Mario Sigalotti AB -Two-dimensional almost-Riemannian structures are generalized Riemannian structures on surfaces for which a local orthonormal frame is given by a Lie bracket generating pair of vector fields that can become collinear. We study the relation between the topological invariants of an almost-Riemannian structure on a compact oriented surface and the rank-two vector bundle over the surface which defines the structure. We analyse the generic case including the presence of tangency points, i.e. points where two generators of the distribution and their Lie bracket are linearly dependent. The main result of the paper provides a classification of oriented almost-Riemannian structures on compact oriented surfaces in terms of the Euler number of the vector bundle corresponding to the structure. Moreover, we present a Gauss-Bonnet formula for almost-Riemannian structures with tangency points.

PB - Elsevier VL - 27 UR - http://hdl.handle.net/1963/3870 U1 - 839 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Well-posed infinite horizon variational problems on a compact manifold JF - Proceedings of the Steklov Institute of Mathematics. Volume 268, Issue 1, 2010, Pages 17-31 Y1 - 2010 A1 - Andrei A. Agrachev AB - We give an effective sufficient condition for a variational problem with infinite horizon on a compact Riemannian manifold M to admit a smooth optimal synthesis, i. e., a smooth dynamical system on M whose positive semi-trajectories are solutions to the problem. To realize the synthesis, we construct an invariant Lagrangian submanifold (well-projected to M) of the flow of extremals in the cotangent bundle T*M. The construction uses the curvature of the flow in the cotangent bundle and some ideas of hyperbolic dynamics PB - SISSA UR - http://hdl.handle.net/1963/6458 U1 - 6404 U2 - Mathematics U4 - 1 U5 - MAT/05 ANALISI MATEMATICA ER - TY - CHAP T1 - Biological Fluid Dynamics, Non-linear Partial Differential Equations T2 - Encyclopedia of Complexity and Systems Science / Robert A. Meyers (ed.). - Springer, 2009, 548-554 Y1 - 2009 A1 - Antonio DeSimone A1 - François Alouges A1 - Aline Lefebvre JF - Encyclopedia of Complexity and Systems Science / Robert A. Meyers (ed.). - Springer, 2009, 548-554 UR - http://hdl.handle.net/1963/2630 U1 - 1493 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Characterization of the time course of changes of the evoked electrical activity in a model of a chemically-induced neuronal plasticity JF - BMC Research Notes (2009) 2:13 Y1 - 2009 A1 - Frederic D. Broccard A1 - Silvia Pegoraro A1 - Maria Elisabetta Ruaro A1 - Claudio Altafini A1 - Vincent Torre AB - BACKGROUND: Neuronal plasticity is initiated by transient elevations of neuronal networks activity leading to changes of synaptic properties and providing the basis for memory and learning 1. An increase of electrical activity can be caused by electrical stimulation 2 or by pharmacological manipulations: elevation of extracellular K+ 3, blockage of inhibitory pathways 4 or by an increase of second messengers intracellular concentrations 5. Neuronal plasticity is mediated by several biochemical pathways leading to the modulation of synaptic strength, density of ionic channels and morphological changes of neuronal arborisation 6. On a time scale of a few minutes, neuronal plasticity is mediated by local protein trafficking 7 while, in order to sustain modifications beyond 2-3 h, changes of gene expression are required 8. FINDINGS: In the present manuscript we analysed the time course of changes of the evoked electrical activity during neuronal plasticity and we correlated it with a transcriptional analysis of the underlying changes of gene expression. Our investigation shows that treatment for 30 min. with the GABAA receptor antagonist gabazine (GabT) causes a potentiation of the evoked electrical activity occurring 2-4 hours after GabT and the concomitant up-regulation of 342 genes. Inhibition of the ERK1/2 pathway reduced but did not abolish the potentiation of the evoked response caused by GabT. In fact not all the genes analysed were blocked by ERK1/2 inhibitors. CONCLUSION: These results are in agreement with the notion that neuronal plasticity is mediated by several distinct pathways working in unison. PB - BioMed Central UR - http://hdl.handle.net/1963/3706 U1 - 599 U2 - Neuroscience U3 - Neurobiology ER - TY - JOUR T1 - Controllability and simultaneous controllability of isospectral bilinear control systems on complex flag manifolds JF - Systems Control Lett. 58 (2009) 213-216 Y1 - 2009 A1 - Claudio Altafini AB - For isospectral bilinear control systems evolving on the so-called complex flag manifolds (i.e., on the orbits of the Hermitian matrices under unitary conjugation action) it is shown that controllability is almost always verified. Easy and generic sufficient conditions are provided. The result applies to the problem of density operator controllability of finite dimensional quantum mechanical systems. In addition, we show that systems having different drifts (corresponding for example to different Larmor frequencies) are simultaneously controllable by the same control field. PB - Elsevier UR - http://hdl.handle.net/1963/3523 U1 - 741 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Controllability on the group of diffeomorphisms JF - Ann. Inst. H. Poincaré Anal. Non Linéaire 26 (2009) 2503-2509 Y1 - 2009 A1 - Andrei A. Agrachev A1 - Marco Caponigro AB - Given a compact manifold M, we prove that any bracket generating family of vector fields on M, which is invariant under multiplication by smooth functions, generates the connected component of identity of the group of diffeomorphisms of M. UR - http://hdl.handle.net/1963/3396 U1 - 936 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - ERNEST: a toolbox for chemical reaction network theory JF - Bioinformatics 25 (2009) 2853-2854 Y1 - 2009 A1 - Nicola Soranzo A1 - Claudio Altafini AB - Summary: ERNEST Reaction Network Equilibria Study Toolbox is a MATLAB package which, by checking various different criteria on the structure of a chemical reaction network, can exclude the multistationarity of the corresponding reaction system. The results obtained are independent of the rate constants of the reactions, and can be used for model discrimination.\\nAvailability and Implementation: The software, implemented in MATLAB, is available under the GNU GPL free software license from http://people.sissa.it/~altafini/papers/SoAl09/. It requires the MATLAB Optimization Toolbox. PB - Oxford University Press UR - http://hdl.handle.net/1963/3826 U1 - 501 U2 - Physics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - The intrinsic hypoelliptic Laplacian and its heat kernel on unimodular Lie groups JF - J. Funct. Anal. 256 (2009) 2621-2655 Y1 - 2009 A1 - Andrei A. Agrachev A1 - Ugo Boscain A1 - Jean-Paul Gauthier A1 - Francesco Rossi AB - We present an invariant definition of the hypoelliptic Laplacian on sub-Riemannian structures with constant growth vector, using the Popp\\\'s volume form introduced by Montgomery. This definition generalizes the one of the Laplace-Beltrami operator in Riemannian geometry. In the case of left-invariant problems on unimodular Lie groups we prove that it coincides with the usual sum of squares.\\nWe then extend a method (first used by Hulanicki on the Heisenberg group) to compute explicitly the kernel of the hypoelliptic heat equation on any unimodular Lie group of type I. The main tool is the noncommutative Fourier transform. We then study some relevant cases: SU(2), SO(3), SL(2) (with the metrics inherited by the Killing form), and the group SE(2) of rototranslations of the plane.\\nOur study is motivated by some recent results about the cut and conjugate loci on these sub-Riemannian manifolds. The perspective is to understand how singularities of the sub-Riemannian distance reflect on the kernel of the corresponding hypoelliptic heat equation. UR - http://hdl.handle.net/1963/2669 U1 - 1428 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Investigating the Conformational Stability of Prion Strains through a Kinetic Replication Model JF - PLoS Comput Biol 2009;5(7): e1000420 Y1 - 2009 A1 - Mattia Zampieri A1 - Giuseppe Legname A1 - Claudio Altafini AB - Prion proteins are known to misfold into a range of different aggregated forms, showing different phenotypic and pathological states. Understanding strain specificities is an important problem in the field of prion disease. Little is known about which PrPSc structural properties and molecular mechanisms determine prion replication, disease progression and strain phenotype. The aim of this work is to investigate, through a mathematical model, how the structural stability of different aggregated forms can influence the kinetics of prion replication. The model-based results suggest that prion strains with different conformational stability undergoing in vivo replication are characterizable in primis by means of different rates of breakage. A further role seems to be played by the aggregation rate (i.e. the rate at which a prion fibril grows). The kinetic variability introduced in the model by these two parameters allows us to reproduce the different characteristic features of the various strains (e.g., fibrils\\\' mean length) and is coherent with all experimental observations concerning strain-specific behavior. PB - PLoS UR - http://hdl.handle.net/1963/3989 U1 - 413 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - mRNA stability and the unfolding of gene expression in the long-period yeast metabolic cycle JF - BMC Systems Biology (2009) 3:18 Y1 - 2009 A1 - Nicola Soranzo A1 - Mattia Zampieri A1 - Lorenzo Farina A1 - Claudio Altafini AB - Background: In yeast, genome-wide periodic patterns associated with energy-metabolic oscillations have been shown recently for both short (approx. 40 min) and long (approx. 300 min) periods.\\nResults: The dynamical regulation due to mRNA stability is found to be an important aspect of the genome-wide coordination of the long-period yeast metabolic cycle. It is shown that for periodic genes, arranged in classes according either to expression profile or to function, the pulses of mRNA abundance have phase and width which are directly proportional to the corresponding turnover rates.\\nConclusion: The cascade of events occurring during the yeast metabolic cycle (and their correlation with mRNA turnover) reflects to a large extent the gene expression program observable in other dynamical contexts such as the response to stresses/stimuli. PB - BioMed Central UR - http://hdl.handle.net/1963/3630 U1 - 674 U2 - Physics U3 - Statistical and Biological Physics ER - TY - JOUR T1 - Optimal transportation under nonholonomic constraints JF - Trans. Amer. Math. Soc. 361 (2009) 6019-6047 Y1 - 2009 A1 - Andrei A. Agrachev A1 - Paul Lee AB - We study the Monge\\\'s optimal transportation problem where the cost is given by optimal control cost. We prove the existence and uniqueness of optimal map under certain regularity conditions on the Lagrangian, absolute continuity of the measures and most importantly the absent of sharp abnormal minimizers. In particular, this result is applicable in the case of subriemannian manifolds with a 2-generating distribution and cost given by d2, where d is the subriemannian distance. Also, we discuss some properties of the optimal plan when abnormal minimizers are present. Finally, we consider some examples of displacement interpolation in the case of Grushin plane. UR - http://hdl.handle.net/1963/2176 U1 - 2068 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Relaxation dynamics of fluid membranes JF - Phys. Rev. E 79 (2009) 031915 Y1 - 2009 A1 - Marino Arroyo A1 - Antonio DeSimone AB - We study the effect of membrane viscosity in the dynamics of liquid membranes-possibly with free or internal boundaries-driven by conservative forces (curvature elasticity and line tension) and dragged by the bulk dissipation of the ambient fluid and the friction occurring when the amphiphilic molecules move relative to each other. To this end, we formulate a continuum model which includes a form of the governing equations for a two-dimensional viscous fluid moving on a curved, time-evolving surface. The effect of membrane viscosity has received very limited attention in previous continuum studies of the dynamics of fluid membranes, although recent coarse-grained discrete simulations suggest its importance. By applying our model to the study of vesiculation and membrane fusion in a simplified geometry, we conclude that membrane viscosity plays a dominant role in the relaxation dynamics of fluid membranes of sizes comparable to those found in eukaryotic cells, and is not negligible in many large synthetic systems of current interest. PB - American Physical Society UR - http://hdl.handle.net/1963/3618 U1 - 686 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Discerning static and causal interactions in genome-wide reverse engineering problems JF - Bioinformatics 24 (2008) 1510-1515 Y1 - 2008 A1 - Mattia Zampieri A1 - Nicola Soranzo A1 - Claudio Altafini AB - Background. In the past years devicing methods for discovering gene regulatory mechanisms at a genome-wide level has become a fundamental topic in the field of system biology. The aim is to infer gene-gene interactions in a more sophisticated and reliable way through the continuously improvement of reverse engineering algorithms exploiting microarray technologies. Motivation. This work is inspired by the several studies suggesting that co-expression is mostly related to \\\"static\\\" stable binding relationships, like belonging to the same protein complex, rather than other types of interactions more of a \\\"causal\\\" and transient nature (metabolic pathway or transcription factor-binding site interaction). Discerning static relationships from causal ones on the basis of their characteristic regulatory structures and in particular identifing \\\"dense modules\\\" with protein complex, and \\\"sparse modules\\\" with causal interactions such as those between transcription factor and corresponding binding site, the performances of different network inference algorithms in artificial and real networks (derived from E.coli and S.cerevisiae) can be tested and compared. Results. Our study shows that methods that try to prune indirect interactions from the inferred gene networks may fail to retrieve genes co-participating in a protein complex. On the other hand they are more robust in the identification of transcription factor-binding sites dependences when multiple transcription factors regulate the expression of the same gene. In the end we confirm the stronger co-expression regarding genes belonging to a protein complex than transcription factor-binding site, according, also, to the effect of multiple transcription factors and a low expression variance. UR - http://hdl.handle.net/1963/2757 U1 - 1943 U2 - Physics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - A Gauss-Bonnet-like formula on two-dimensional almost-Riemannian manifolds JF - Discrete Contin. Dyn. Syst. 20 (2008) 801-822 Y1 - 2008 A1 - Andrei A. Agrachev A1 - Ugo Boscain A1 - Mario Sigalotti AB - We consider a generalization of Riemannian geometry that naturally arises in the framework of control theory. Let $X$ and $Y$ be two smooth vector fields on a two-dimensional manifold $M$. If $X$ and $Y$ are everywhere linearly independent, then they define a classical Riemannian metric on $M$ (the metric for which they are orthonormal) and they give to $M$ the structure of metric space. If $X$ and $Y$ become linearly dependent somewhere on $M$, then the corresponding Riemannian metric has singularities, but under generic conditions the metric structure is still well defined. Metric structures that can be defined locally in this way are called almost-Riemannian structures. They are special cases of rank-varying sub-Riemannian structures, which are naturally defined in terms of submodules of the space of smooth vector fields on $M$. Almost-Riemannian structures show interesting phenomena, in particular for what concerns the relation between curvature, presence of conjugate points, and topology of the manifold. The main result of the paper is a generalization to almost-Riemannian structures of the Gauss-Bonnet formula. UR - http://hdl.handle.net/1963/1869 U1 - 2353 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Multiple bound states for the Schroedinger-Poisson problem JF - Commun. Contemp. Math. 10 (2008) 391-404 Y1 - 2008 A1 - Antonio Ambrosetti A1 - David Ruiz UR - http://hdl.handle.net/1963/2679 U1 - 1421 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Optimal Strokes for Low Reynolds Number Swimmers: An Example JF - J. Nonlinear Sci. 18 (2008) 277-302 Y1 - 2008 A1 - François Alouges A1 - Antonio DeSimone A1 - Aline Lefebvre AB - Swimming, i.e., being able to advance in the absence of external forces by performing cyclic shape changes, is particularly demanding at low Reynolds numbers. This is the regime of interest for micro-organisms and micro- or nano-robots. We focus in this paper on a simple yet representative example: the three-sphere swimmer of Najafi and Golestanian (Phys. Rev. E, 69, 062901-062904, 2004). For this system, we show how to cast the problem of swimming in the language of control theory, prove global controllability (which implies that the three-sphere swimmer can indeed swim), and propose a numerical algorithm to compute optimal strokes (which turn out to be suitably defined sub-Riemannian geodesics). PB - Springer UR - http://hdl.handle.net/1963/4006 U1 - 396 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Origin of Co-Expression Patterns in E.coli and S.cerevisiae Emerging from Reverse Engineering Algorithms JF - PLoS ONE 3 (2008) e2981 Y1 - 2008 A1 - Mattia Zampieri A1 - Nicola Soranzo A1 - Daniele Bianchini A1 - Claudio Altafini AB - Background: The concept of reverse engineering a gene network, i.e., of inferring a genome-wide graph of putative genegene interactions from compendia of high throughput microarray data has been extensively used in the last few years to deduce/integrate/validate various types of \\\"physical\\\" networks of interactions among genes or gene products. Results: This paper gives a comprehensive overview of which of these networks emerge significantly when reverse engineering large collections of gene expression data for two model organisms, E.coli and S.cerevisiae, without any prior information. For the first organism the pattern of co-expression is shown to reflect in fine detail both the operonal structure of the DNA and the regulatory effects exerted by the gene products when co-participating in a protein complex. For the second organism we find that direct transcriptional control (e.g., transcription factor-binding site interactions) has little statistical significance in comparison to the other regulatory mechanisms (such as co-sharing a protein complex, colocalization on a metabolic pathway or compartment), which are however resolved at a lower level of detail than in E.coli. Conclusion: The gene co-expression patterns deduced from compendia of profiling experiments tend to unveil functional categories that are mainly associated to stable bindings rather than transient interactions. The inference power of this systematic analysis is substantially reduced when passing from E.coli to S.cerevisiae. This extensive analysis provides a way to describe the different complexity between the two organisms and discusses the critical limitations affecting this type of methodologies. UR - http://hdl.handle.net/1963/2722 U1 - 1379 U2 - Physics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Relaxation of some transversally isotropic energies and applications to smectic A elastomers JF - Math. Models Methods Appl. Sci. 18 (2008) 1-20 Y1 - 2008 A1 - James Adams A1 - Sergio Conti A1 - Antonio DeSimone A1 - Georg Dolzmann UR - http://hdl.handle.net/1963/1912 U1 - 2325 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Solitons of linearly coupled systems of semilinear non-autonomous equations on Rn JF - J. Funct. Anal. 254 (2008) 2816-2845 Y1 - 2008 A1 - Antonio Ambrosetti A1 - Giovanna Cerami A1 - David Ruiz AB - Using concentration compactness type arguments, we prove some results about the existence of positive ground and bound state of linearly coupled systems of nonlinear Schrödinger equations. UR - http://hdl.handle.net/1963/2175 U1 - 2069 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Comparing association network algorithms for reverse engineering of large scale gene regulatory networks: synthetic vs real data JF - Bioinformatics 23 (2007) 1640-1647 Y1 - 2007 A1 - Nicola Soranzo A1 - Ginestra Bianconi A1 - Claudio Altafini AB - Motivation: Inferring a gene regulatory network exclusively from microarray expression profiles is a difficult but important task. The aim of this work is to compare the predictive power of some of the most popular algorithms in different conditions (like data taken at equilibrium or time courses) and on both synthetic and real microarray data. We are in particular interested in comparing similarity measures both of linear type (like correlations and partial correlations) and of nonlinear type (mutual information and conditional mutual information), and in investigating the underdetermined case (less samples than genes). Results: In our simulations we see that all network inference algorithms obtain better performances from data produced with \\\"structural\\\" perturbations, like gene knockouts at steady state, than with any dynamical perturbation. The predictive power of all algorithms is confirmed on a reverse engineering problem from E. coli gene profiling data: the edges of the \\\"physical\\\" network of transcription factor-binding sites are significantly overrepresented among the highest weighting edges of the graph that we infer directly from the data without any structure supervision. Comparing synthetic and in vivo data on the same network graph allows us to give an indication of how much more complex a real transcriptional regulation program is with respect to an artificial model. Availability: Software and supplementary material are freely available at the URL http://people.sissa.it/~altafini/papers/SoBiAl07/ UR - http://hdl.handle.net/1963/2028 U1 - 2168 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - CHAP T1 - Concentration phenomena for nonlinear Schrödinger equations: Recent results and new perspectives T2 - Perspectives in Nonlinear Partial Differential Equations: In Honor of Haïm Brezis / ed. by Henri Beresticky [et al.]. - Providence : American Mathematical Society, 2007. - (Contemporary mathematics ; 446). - p. 19-30 Y1 - 2007 A1 - Antonio Ambrosetti A1 - Andrea Malchiodi AB - We survey some results on (NLSepsilon), discussing also new perspectives and open problems. JF - Perspectives in Nonlinear Partial Differential Equations: In Honor of Haïm Brezis / ed. by Henri Beresticky [et al.]. - Providence : American Mathematical Society, 2007. - (Contemporary mathematics ; 446). - p. 19-30 PB - American Mathematical Society UR - http://hdl.handle.net/1963/3516 U1 - 748 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - On feedback classification of control-affine systems with one and two-dimensional inputs JF - SIAM J. Control Optim. 46 (2007) 1431-1460 Y1 - 2007 A1 - Andrei A. Agrachev A1 - Igor Zelenko AB - The paper is devoted to the local classification of generic control-affine systems on an n-dimensional manifold with scalar input for any n>3 or with two inputs for n=4 and n=5, up to state-feedback transformations, preserving the affine structure. First using the Poincare series of moduli numbers we introduce the intrinsic numbers of functional moduli of each prescribed number of variables on which a classification problem depends. In order to classify affine systems with scalar input we associate with such a system the canonical frame by normalizing some structural functions in a commutative relation of the vector fields, which define our control system. Then, using this canonical frame, we introduce the canonical coordinates and find a complete system of state-feedback invariants of the system. It also gives automatically the micro-local (i.e. local in state-input space) classification of the generic non-affine n-dimensional control system with scalar input for n>2. Further we show how the problem of feedback-equivalence of affine systems with two-dimensional input in state space of dimensions 4 and 5 can be reduced to the same problem for affine systems with scalar input. In order to make this reduction we distinguish the subsystem of our control system, consisting of the directions of all extremals in dimension 4 and all abnormal extremals in dimension 5 of the time optimal problem, defined by the original control system. In each classification problem under consideration we find the intrinsic numbers of functional moduli of each prescribed number of variables according to its Poincare series. UR - http://hdl.handle.net/1963/2186 U1 - 2058 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - RPRT T1 - Feedback control of spin systems Y1 - 2007 A1 - Claudio Altafini AB - The feedback stabilization problem for ensembles of coupled spin 1/2 systems is discussed from a control theoretic perspective. The noninvasive nature of the bulk measurement allows for a fully unitary and deterministic closed loop. The Lyapunov-based feedback design presented does not require spins that are selectively addressable. With this method, it is possible to obtain control inputs also for difficult tasks, like suppressing undesired couplings in identical spin systems. JF - Quantum Inf. Process. 6 (2007) 9-36 UR - http://hdl.handle.net/1963/1808 N1 - Proc. of the 44th IEEE Conf. on Decision and Control,. Seville, Spain, December 2005 (to appear). U1 - 2406 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Feedback stabilization of quantum ensembles: a global convergence analysis on complex flag manifolds JF - 45th IEEE Conference on Decision and Control (2007) 2471-2476 Y1 - 2007 A1 - Claudio Altafini AB - In an N-level quantum mechanical system, the problem of unitary feedback stabilization of mixed density operators to periodic orbits admits a natural Lyapunov-based time-varying feedback design. A global description of the domain of attraction of the closed-loop system can be provided based on a \\\"root-space\\\"-like structure of the space of density operators. This convex set foliates as a complex flag manifold where each leaf is identified with the coadjoint orbit of the eigenvalues of the density operator. The converging conditions are time-independent but depend from the topology of the flag manifold: it is shown that the closed loop must have a number of equilibria at least equal to the Euler characteristic of the manifold, thus imposing obstructions of topological nature to global stabilizability. UR - http://hdl.handle.net/1963/1729 U1 - 2422 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - On finite-dimensional projections of distributions for solutions of randomly forced PDE\\\'s JF - Ann. Inst. Henri Poincare-Prob. Stat. 43 (2007) 399-415 Y1 - 2007 A1 - Andrei A. Agrachev A1 - Sergei Kuksin A1 - Andrey Sarychev A1 - Armen Shirikyan AB - The paper is devoted to studying the image of probability measures on a Hilbert space under finite-dimensional analytic maps. We establish sufficient conditions under which the image of a measure has a density with respect to the Lebesgue measure and continuously depends on the map. The results obtained are applied to the 2D Navier-Stokes equations perturbed by various random forces of low dimension. UR - http://hdl.handle.net/1963/2012 U1 - 2184 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - RPRT T1 - Multi-bump solitons to linearly coupled systems of nonlinear Schrödinger equations Y1 - 2007 A1 - Antonio Ambrosetti A1 - Eduardo Colorado A1 - David Ruiz JF - Calc. Var. Partial Differential Equations 30 (2007) 85-112 UR - http://hdl.handle.net/1963/1835 U1 - 2381 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Nearly time optimal stabilizing patchy feedbacks JF - Ann. Inst. H. Poincare Anal. Non Lineaire 24 (2007) 279-310 Y1 - 2007 A1 - Fabio Ancona A1 - Alberto Bressan AB - We consider the time optimal stabilization problem for a nonlinear control system $\\\\dot x=f(x,u)$. Let $\\\\tau(y)$ be the minimum time needed to steer the system from the state $y\\\\in\\\\R^n$ to the origin, and call $\\\\A(T)$ the set of initial states that can be steered to the origin in time $\\\\tau(y)\\\\leq T$. Given any $\\\\ve>0$, in this paper we construct a patchy feedback $u=U(x)$ such that every solution of $\\\\dot x=f(x, U(x))$, $x(0)=y\\\\in \\\\A(T)$ reaches an $\\\\ve$-neighborhood of the origin within time $\\\\tau(y)+\\\\ve$. UR - http://hdl.handle.net/1963/2185 U1 - 2059 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - The number of eigenvalues of three-particle Schrödinger operators on lattices JF - J. Phys. A 40 (2007) 14819-14842 Y1 - 2007 A1 - Sergio Albeverio A1 - Gianfausto Dell'Antonio A1 - Saidakhmat N. Lakaev AB - We consider the Hamiltonian of a system of three quantum mechanical particles (two identical fermions and boson)on the three-dimensional lattice $\\\\Z^3$ and interacting by means of zero-range attractive potentials. We describe the location and structure of the essential spectrum of the three-particle discrete Schr\\\\\\\"{o}dinger operator $H_{\\\\gamma}(K),$ $K$ being the total quasi-momentum and $\\\\gamma>0$ the ratio of the mass of fermion and boson.\\nWe choose for $\\\\gamma>0$ the interaction $v(\\\\gamma)$ in such a way the system consisting of one fermion and one boson has a zero energy resonance.\\nWe prove for any $\\\\gamma> 0$ the existence infinitely many eigenvalues of the operator $H_{\\\\gamma}(0).$ We establish for the number $N(0,\\\\gamma; z;)$ of eigenvalues lying below $z<0$ the following asymptotics $$ \\\\lim_{z\\\\to 0-}\\\\frac{N(0,\\\\gamma;z)}{\\\\mid \\\\log \\\\mid z\\\\mid \\\\mid}={U} (\\\\gamma) .$$ Moreover, for all nonzero values of the quasi-momentum $K \\\\in T^3 $ we establish the finiteness of the number $ N(K,\\\\gamma;\\\\tau_{ess}(K))$ of eigenvalues of $H(K)$ below the bottom of the essential spectrum and we give an asymptotics for the number $N(K,\\\\gamma;0)$ of eigenvalues below zero. UR - http://hdl.handle.net/1963/2576 U1 - 1545 U2 - Mathematics U3 - Mathematical Physics ER - TY - JOUR T1 - Reciprocal transformations and flat metrics on Hurwitz spaces JF - J. Phys. A 40 (2007) 10769-10790 Y1 - 2007 A1 - Simonetta Abenda A1 - Tamara Grava AB - We consider hydrodynamic systems which possess a local Hamiltonian structure of Dubrovin-Novikov type. To such a system there are also associated an infinite number of nonlocal Hamiltonian structures. We give necessary and sufficient conditions so that, after a nonlinear transformation of the independent variables, the reciprocal system still possesses a local Hamiltonian structure of Dubrovin-Novikov type. We show that, under our hypotheses, bi-hamiltonicity is preserved by the reciprocal transformation. Finally we apply such results to reciprocal systems of genus g Whitham-KdV modulation equations. UR - http://hdl.handle.net/1963/2210 U1 - 2034 U2 - Mathematics U3 - Mathematical Physics ER - TY - RPRT T1 - Soft elasticity and microstructure in smectic C elastomers Y1 - 2007 A1 - Antonio DeSimone A1 - James Adams A1 - Sergio Conti AB - Smectic C elastomers are layered materials exhibiting a solid-like elastic response along the layer normal and a rubbery one in the plane. The set of strains minimizing the elastic energy contains a one-parameter family of simple stretches associated with an internal degree of freedom, coming from the in-plane component of the director. We investigate soft elasticity and the corresponding microstructure by determining the quasiconvex hull of the set , and use this to propose experimental tests that should make the predicted soft response observable. JF - Contin. Mech. Thermodyn. 18 (2007) 319-334 UR - http://hdl.handle.net/1963/1811 U1 - 2403 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - RPRT T1 - Standing waves of some coupled Nonlinear Schrödinger Equations Y1 - 2007 A1 - Antonio Ambrosetti A1 - Eduardo Colorado AB - We deal with a class of systems of NLS equations, proving the existence of bound and ground states provided the coupling parameter is small, respectively, large. JF - J. Lond. Math. Soc. 75 (2007) 67-82 UR - http://hdl.handle.net/1963/1821 U1 - 2393 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - RPRT T1 - Almost Global Stochastic Feedback Stabilization of Conditional Quantum Dynamics Y1 - 2006 A1 - Claudio Altafini A1 - Francesco Ticozzi AB - We propose several parametrization-free solutions to the problem of quantum state reduction control by means of continuous measurement and smooth quantum feedback. In particular, we design a feedback law for which almost global stochastic feedback stabilization can be proved analytically by means of Lyapunov techinques. This synthesis arises very naturally from the physics of the problem, as it relies on the variance associated with the quantum filtering process. UR - http://hdl.handle.net/1963/1727 U1 - 2424 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Bound and ground states of coupled nonlinear Schrödinger equations JF - C. R. Acad. Sci. Paris, Ser. I 342 (2006) 453-458 Y1 - 2006 A1 - Antonio Ambrosetti A1 - Eduardo Colorado AB - We prove existence of bound and ground states of some systems of coupled nonlinear Schrodinger equations. UR - http://hdl.handle.net/1963/2149 U1 - 2094 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Bound states of Nonlinear Schroedinger Equations with Potentials Vanishing at Infinity JF - J. Anal. Math. 98 (2006) 317-348 Y1 - 2006 A1 - Antonio Ambrosetti A1 - Andrea Malchiodi A1 - David Ruiz UR - http://hdl.handle.net/1963/1756 U1 - 2788 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - A cyclic integral on k-Minkowski noncommutative space-time JF - Int. J. Mod. Phys. A 21 (2006) 3133-3150 Y1 - 2006 A1 - Alessandra Agostini A1 - Giovanni Amelino-Camelia A1 - Michele Arzano A1 - Francesco D'Andrea AB - We examine some alternative possibilities for an action functional for $\\\\kappa$-Minkowski noncommutative spacetime, with an approach which should be applicable to other spacetimes with coordinate-dependent commutators of the spacetime coordinates ($[x_\\\\mu,x_\\\\nu]=f_{\\\\mu,\\\\nu}(x)$). Early works on $\\\\kappa$-Minkowski focused on $\\\\kappa$-Poincar\\\\\\\'e covariance and the dependence of the action functional on the choice of Weyl map, renouncing to invariance under cyclic permutations of the factors composing the argument of the action functional. A recent paper (hep-th/0307149), by Dimitrijevic, Jonke, Moller, Tsouchnika, Wess and Wohlgenannt, focused on a specific choice of Weyl map and, setting aside the issue of $\\\\kappa$-Poincar\\\\\\\'e covariance of the action functional, introduced in implicit form a cyclicity-inducing measure. We provide an explicit formula for (and derivation of) a choice of measure which indeed ensures cyclicity of the action functional, and we show that the same choice of measure is applicable to all the most used choices of Weyl map. We find that this ``cyclicity-inducing measure\\\'\\\' is not covariant under $\\\\kappa$-Poincar\\\\\\\'e transformations. We also notice that the cyclicity-inducing measure can be straightforwardly derived using a map which connects the $\\\\kappa$-Minkowski spacetime coordinates and the spacetime coordinates of a ``canonical\\\'\\\' noncommutative spacetime, with coordinate-independent commutators. UR - http://hdl.handle.net/1963/2158 U1 - 2086 U2 - Mathematics U3 - Mathematical Physics ER - TY - JOUR T1 - An estimation of the controllability time for single-input systems on compact Lie Groups JF - ESAIM Control Optim. Calc. Var. 12 (2006) 409-441 Y1 - 2006 A1 - Andrei A. Agrachev A1 - Thomas Chambrion AB - Geometric control theory and Riemannian techniques are used to describe the reachable set at time t of left invariant single-input control systems on semi-simple compact Lie groups and to estimate the minimal time needed to reach any point from identity. This method provides an effective way to give an upper and a lower bound for the minimal time needed to transfer a controlled quantum system with a drift from a given initial position to a given final position. The bounds include diameters of the flag manifolds; the latter are also explicitly computed in the paper. UR - http://hdl.handle.net/1963/2135 U1 - 2108 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Experimental and modeling studies of desensitization of P2X3 receptors. JF - Molecular pharmacology. 2006 Jul; 70(1):373-82 Y1 - 2006 A1 - Elena Sokolova A1 - Andrei Skorinkin A1 - Igor Moiseev A1 - Andrei A. Agrachev A1 - Andrea Nistri A1 - Rashid Giniatullin AB - The function of ATP-activated P2X3 receptors involved in pain sensation is modulated by desensitization, a phenomenon poorly understood. The present study used patch-clamp recording from cultured rat or mouse sensory neurons and kinetic modeling to clarify the properties of P2X3 receptor desensitization. Two types of desensitization were observed, a fast process (t1/2 = 50 ms; 10 microM ATP) following the inward current evoked by micromolar agonist concentrations, and a slow process (t1/2 = 35 s; 10 nM ATP) that inhibited receptors without activating them. We termed the latter high-affinity desensitization (HAD). Recovery from fast desensitization or HAD was slow and agonist-dependent. When comparing several agonists, there was analogous ranking order for agonist potency, rate of desensitization and HAD effectiveness, with 2-methylthioadenosine triphosphate the strongest and beta,gamma-methylene-ATP the weakest. HAD was less developed with recombinant (ATP IC50 = 390 nM) than native P2X3 receptors (IC50 = 2.3 nM). HAD could also be induced by nanomolar ATP when receptors seemed to be nondesensitized, indicating that resting receptors could express high-affinity binding sites. Desensitization properties were well accounted for by a cyclic model in which receptors could be desensitized from either open or closed states. Recovery was assumed to be a multistate process with distinct kinetics dependent on the agonist-dependent dissociation rate from desensitized receptors. Thus, the combination of agonist-specific mechanisms such as desensitization onset, HAD, and resensitization could shape responsiveness of sensory neurons to P2X3 receptor agonists. By using subthreshold concentrations of an HAD-potent agonist, it might be possible to generate sustained inhibition of P2X3 receptors for controlling chronic pain. PB - the American Society for Pharmacology and Experimental Therapeutics UR - http://hdl.handle.net/1963/4974 U1 - 4799 U2 - Neuroscience U3 - Neurobiology U4 - -1 ER - TY - JOUR T1 - Homogeneous polynomial forms for simultaneous stabilizability of families of linear control systems: a tensor product approach JF - IEEE Trans. Automat. Control 51 (2006) 1566-1571 Y1 - 2006 A1 - Claudio Altafini AB - The paper uses the formalism of tensor products in order to deal with the problem of simultaneous\\nstabilizability of a family of linear control systems by means of Lyapunov functions which are homogeneous polynomial forms. While the feedback synthesis seems to be nonconvex, the simultaneous stability by means of homogeneous polynomial forms of the uncontrollable modes yields (convex) necessary but not sufficient conditions for simultaneous stabilizability. UR - http://hdl.handle.net/1963/2226 U1 - 2018 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Radial solutions concentrating on spheres of nonlinear Schrödinger equations with vanishing potentials JF - Proc. Roy. Soc. Edinburgh Sect. A 136 (2006) 889-907 Y1 - 2006 A1 - Antonio Ambrosetti A1 - David Ruiz AB - We prove the existence of radial solutions of 1.2) concentrating at a sphere for potentials which might be zero and might decay to zero at\\r\\ninfinity. The proofs use a perturbation technique in a variational setting, through a Lyapunov-Schmidt reduction. UR - http://hdl.handle.net/1963/1755 U1 - 2789 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Reflection symmetries for multiqubit density operators JF - J. Math. Phys. 47 (2006) 032104 Y1 - 2006 A1 - Claudio Altafini A1 - Timothy F. Havel AB - For multiqubit density operators in a suitable tensorial basis, we show that a number of nonunitary operations used in the detection and synthesis of entanglement are classifiable as reflection symmetries, i.e., orientation changing rotations. While one-qubit reflections correspond to antiunitary symmetries, as is known for example from the partial transposition criterion, reflections on the joint density of two or more qubits are not accounted for by the Wigner Theorem and are well-posed only for sufficiently mixed states. One example of such nonlocal reflections is the unconditional NOT operation on a multiparty density, i.e., an operation yelding another density and such that the sum of the two is the identity operator. This nonphysical operation is admissible only for sufficiently mixed states. UR - http://hdl.handle.net/1963/2121 U1 - 2122 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - On the attainable set for Temple class systems with boundary controls JF - SIAM J. Control Optim. 43 (2005) 2166-2190 Y1 - 2005 A1 - Fabio Ancona A1 - Giuseppe Maria Coclite AB - Consider the initial-boundary value problem for a strictly hyperbolic, genuinely nonlinear, Temple class system of conservation laws % $$ u_t+f(u)_x=0, \\\\qquad u(0,x)=\\\\ov u(x), \\\\qquad {{array}{ll} &u(t,a)=\\\\widetilde u_a(t), \\\\noalign{\\\\smallskip} &u(t,b)=\\\\widetilde u_b(t), {array}. \\\\eqno(1) $$ on the domain $\\\\Omega =\\\\{(t,x)\\\\in\\\\R^2 : t\\\\geq 0, a \\\\le x\\\\leq b\\\\}.$ We study the mixed problem (1) from the point of view of control theory, taking the initial data $\\\\bar u$ fixed, and regarding the boundary data $\\\\widetilde u_a, \\\\widetilde u_b$ as control functions that vary in prescribed sets $\\\\U_a, \\\\U_b$, of $\\\\li$ boundary controls. In particular, we consider the family of configurations $$ \\\\A(T) \\\\doteq \\\\big\\\\{u(T,\\\\cdot); ~ u {\\\\rm is a sol. to} (1), \\\\quad \\\\widetilde u_a\\\\in \\\\U_a, \\\\widetilde u_b \\\\in \\\\U_b \\\\big\\\\} $$ that can be attained by the system at a given time $T>0$, and we give a description of the attainable set $\\\\A(T)$ in terms of suitable Oleinik-type conditions. We also establish closure and compactness of the set $\\\\A(T)$ in the $lu$ topology. PB - SISSA Library UR - http://hdl.handle.net/1963/1581 U1 - 2537 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Commuting multiparty quantum observables and local compatibility JF - Phys. Rev. A 72 (2005) 012112 Y1 - 2005 A1 - Claudio Altafini AB - A formula for the commutator of tensor product matrices is used to shows that, for qubits, compatibility of quantum multiparty observables almost never implies local compatibility at each site and to predict when this happens/does not happen in a concise manner. In particular, it is shown that two ``fully nontrivial\\\'\\\' $n$-qubit observables are compatible locally and globally if and only if they are equal up to sign. In addition, the formula gives insight into the construction of new paradoxes of the type of the Kochen-Specker Theorem, which can then be easily rephrased into proposals for new no hidden variable experiments of the type of the ``Bell Theorem without inequalities\\\'\\\'. UR - http://hdl.handle.net/1963/2228 U1 - 2016 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - On curvatures and focal points of distributions of dynamical Lagrangian distributions and their reductions by first integrals JF - J. Dyn. Control Syst. 11 (2005) 297-327 Y1 - 2005 A1 - Andrei A. Agrachev A1 - Natalia N. Chtcherbakova A1 - Igor Zelenko AB - Pairs (Hamiltonian system, Lagrangian distribution), called dynamical Lagrangian distributions, appear naturally in Differential Geometry, Calculus of Variations and Rational Mechanics. The basic differential invariants of a dynamical Lagrangian distribution w.r.t. the action of the group of symplectomorphisms of the ambient symplectic manifold are the curvature operator and the curvature form. These invariants can be seen as generalizations of the classical curvature tensor in Riemannian Geometry. In particular, in terms of these invariants one can localize the focal points along extremals of the corresponding variational problems. In the present paper we study the behavior of the curvature operator, the curvature form and the focal points of a dynamical Lagrangian distribution after its reduction by arbitrary first integrals in involution. The interesting phenomenon is that the curvature form of so-called monotone increasing Lagrangian dynamical distributions, which appear naturally in mechanical systems, does not decrease after reduction. It also turns out that the set of focal points to the given point w.r.t. the monotone increasing dynamical Lagrangian distribution and the corresponding set of focal points w.r.t. its reduction by one integral are alternating sets on the corresponding integral curve of the Hamiltonian system of the considered dynamical distributions. Moreover, the first focal point corresponding to the reduced Lagrangian distribution comes before any focal point related to the original dynamical distribution. We illustrate our results on the classical $N$-body problem. UR - http://hdl.handle.net/1963/2254 U1 - 1993 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Explicit Wei–Norman formulae for matrix Lie groups via Putzer\\\'s method JF - Systems and Control Letters, 54 (11):1121-1130, 2005 Y1 - 2005 A1 - Claudio Altafini AB - The Wei–Norman formula locally relates the Magnus solution of a system of linear time-varying ODEs with the solution expressed in terms of products of exponentials by means of a set of nonlinear differential equations in the parameters of the two types of solutions. A closed form expression of such formula is proposed based on the use of Putzer\\\'s method. PB - Elsevier UR - http://hdl.handle.net/1963/4538 U1 - 4299 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - Ground states of nonlinear Schroedinger equations with potentials vanishing at infinity JF - J. Eur. Math. Soc. 7 (2005) 117-144 Y1 - 2005 A1 - Antonio Ambrosetti A1 - Veronica Felli A1 - Andrea Malchiodi AB - We deal with a class on nonlinear Schr\\\\\\\"odinger equations \\\\eqref{eq:1} with potentials $V(x)\\\\sim |x|^{-\\\\a}$, $0<\\\\a<2$, and $K(x)\\\\sim |x|^{-\\\\b}$, $\\\\b>0$. Working in weighted Sobolev spaces, the existence of ground states $v_{\\\\e}$ belonging to $W^{1,2}(\\\\Rn)$ is proved under the assumption that $p$ satisfies \\\\eqref{eq:p}. Furthermore, it is shown that $v_{\\\\e}$ are {\\\\em spikes} concentrating at a minimum of ${\\\\cal A}=V^{\\\\theta}K^{-2/(p-1)}$, where $\\\\theta= (p+1)/(p-1)-1/2$. UR - http://hdl.handle.net/1963/2352 U1 - 1664 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Modulation of the Camassa-Holm equation and reciprocal transformations JF - Ann. Inst. Fourier (Grenoble) 55 (2005) 1803-1834 Y1 - 2005 A1 - Simonetta Abenda A1 - Tamara Grava AB - We derive the modulation equations or Whitham equations for the Camassa-Holm (CH) equation. We show that the modulation equations are hyperbolic and admit bi-Hamiltonian structure. Furthermore they are connected by a reciprocal transformation to the modulation equations of the first negative flow of the Korteweg de Vries (KdV) equation. The reciprocal transformation is generated by the Casimir of the second Poisson bracket of the KdV averaged flow. We show that the geometry of the bi-Hamiltonian structure of the KdV and CH modulation equations is quite different: indeed the KdV averaged bi-Hamiltonian structure can always be related to a semisimple Frobenius manifold while the CH one cannot. UR - http://hdl.handle.net/1963/2305 U1 - 1711 U2 - Mathematics U3 - Mathematical Physics ER - TY - RPRT T1 - Nonlinear Schrödinger Equations with vanishing and decaying potentials Y1 - 2005 A1 - Antonio Ambrosetti A1 - Wang Zhi-Qiang JF - Differential Integral Equations 18 (2005), no. 12, 1321-1332 UR - http://hdl.handle.net/1963/1760 U1 - 2784 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Wetting of rough surfaces: a homogenization approach JF - Proc. R. Soc. Lon. Ser. A 461 (2005) 79-97 Y1 - 2005 A1 - Antonio DeSimone A1 - Giovanni Alberti AB - The contact angle of a drop in equilibrium on a solid is strongly affected by the roughness of the surface on which it rests. We study the roughness-induced enhancement of the hydrophobic or hydrophilic properties of a solid surface through homogenization theory. By relying on a variational formulation of the problem, we show that the macroscopic contact angle is associated with the solution of two cell problems, giving the minimal energy per unit macroscopic area for a transition layer between the rough solid surface and a liquid or vapor phase. Our results are valid for both chemically heterogeneous and homogeneous surfaces. In the latter case, a very transparent structure emerges from the variational\\napproach: the classical laws of Wenzel and Cassie-Baxter give bounds for the optimal energy, and configurations of minimal energy are those leading to the smallest macroscopic contact angle in the hydrophobic case, to the largest one in the hydrophilic case. UR - http://hdl.handle.net/1963/2253 U1 - 1994 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Blow-up solutions for the Schrödinger equation in dimension three with a concentrated nonlinearity JF - Ann. Inst. H. Poincare Anal. Non Lineaire 21 (2004) 121-137 Y1 - 2004 A1 - Riccardo Adami A1 - Gianfausto Dell'Antonio A1 - Rodolfo Figari A1 - Alessandro Teta AB - We present some results on the blow-up phenomenon for the Schroedinger equation in dimension three with a nonlinear term supported in a fixed point. We find sufficient conditions for the blow up exploiting the moment of inertia of the solution and the uncertainty principle. In the critical case, we discuss the additional symmetry of the equation and construct a family of explicit blow up solutions. PB - Elsevier UR - http://hdl.handle.net/1963/2998 U1 - 1335 U2 - Mathematics U3 - Mathematical Physics ER - TY - JOUR T1 - Coherent control of open quantum dynamical systems JF - Phys. Rev. A 70 (2004) 062321 Y1 - 2004 A1 - Claudio Altafini AB - A systematic analysis of the behavior of the quantum Markovian master equation driven by coherent control fields is proposed. Its irreversible character is formalized using control-theoretic notions and the sets of states that can be reached via cohere nt controls are described. The analysis suggests to which extent (and how) it is possible to counteract the effect of dissipation. UR - http://hdl.handle.net/1963/2227 U1 - 2017 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Energetics and switching of quasi-uniform states in small ferromagnetic particles JF - M2AN Math. Model. Numer. Anal. 38 (2004) 235-248 Y1 - 2004 A1 - François Alouges A1 - Sergio Conti A1 - Antonio DeSimone A1 - Ivo Pokern AB - We present a numerical algorithm to solve the micromagnetic equations based on tangential-plane minimization for the magnetization update and a homothethic-layer decomposition of outer space for the computation of the demagnetization field. As a first application, detailed results on the flower-vortex transition in the cube of Micromagnetic Standard Problem number 3 are obtained, which confirm, with a different method, those already present in the literature, and validate our method and code. We then turn to switching of small cubic or almost-cubic particles, in the single-domain limit. Our data show systematic deviations from the Stoner-Wohlfarth model due to the non-ellipsoidal shape of the particle, and in particular a non-monotone dependence on the particle size. PB - EDP Sciences UR - http://hdl.handle.net/1963/2999 U1 - 1334 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Reduction by group symmetry of second order variational problems on a semidirect product of Lie groups with positive definite Riemannian metric JF - ESAIM: COCV 10 (2004) 526-548 Y1 - 2004 A1 - Claudio Altafini AB - For a Riemannian structure on a semidirect product of Lie groups, the variational problems can be reduced using the group symmetry. Choosing the Levi-Civita connection of a positive definite metric tensor, instead of any of the canonical connections for the Lie group, simplifies the reduction of the variations but complicates the expression for the Lie algebra valued covariant derivatives. The origin of the discrepancy is in the semidirect product structure, which implies that the Riemannian exponential map and the Lie group exponential map do not coincide. The consequence is that the reduced equations look more complicated than the original ones. The main scope of this paper is to treat the reduction of second order variational problems (corresponding to geometric splines) on such semidirect products of Lie groups. Due to the semidirect structure, a number of extra terms appears in the reduction, terms that are calculated explicitely. The result is used to compute the necessary conditions of an optimal control problem for a simple mechanical control system having invariant Lagrangian equal to the kinetic energy corresponding to the metric tensor. As an example, the case of a rigid body on the Special Euclidean group is considered in detail. PB - EDP Sciences UR - http://hdl.handle.net/1963/3521 U1 - 743 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Representing multiqubit unitary evolutions via Stokes tensors JF - Phys. Rev. A 70 (2004) 032331 Y1 - 2004 A1 - Claudio Altafini AB - For the Stokes tensor parametrization of a multiqubit density operator, we provide an explicit formulation of the corresponding unitary dynamics at the infinitesimal level. The main advantage of this formalism (clearly reminiscent of the ideas of ``coherences\\\'\\\' and ``coupling Hamiltonians\\\'\\\' of spin systems) is that the pattern of correlation between qubits and the pattern of infinitesimal correlation are highlighted simultaneously and can be used constructively for qubit manipulation. For example, it allows to compute explicitly a Rodrigues\\\' formula for the one-parameter orbits of nonlocal Hamiltonians. The result is easily generalizable to orbits of Cartan subalgebras and allows to express the Cartan decomposition of unitary propagators as a linear action directly in terms of the infinitesimal generators. UR - http://hdl.handle.net/1963/2307 U1 - 1709 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Singularity perturbed elliptic equations with symmetry: existence of solutions concetrating on spheres, Part II JF - Indiana Univ. Math. J. 53 (2004) 297-392 Y1 - 2004 A1 - Antonio Ambrosetti A1 - Andrea Malchiodi A1 - Wei-Ming Ni PB - Indiana University Mathematics Journal UR - http://hdl.handle.net/1963/1663 U1 - 2455 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Stability rates for patchy vector fields JF - ESAIM COCV 10 (2004) 168-200 Y1 - 2004 A1 - Fabio Ancona A1 - Alberto Bressan AB - This paper is concerned with the stability of the set of trajectories of a patchy vector field, in the presence of impulsive perturbations. Patchy vector fields are discontinuous, piecewise smooth vector fields that were introduced in Ancona and Bressan (1999) to study feedback stabilization problems. For patchy vector fields in the plane, with polygonal patches in generic position, we show that the distance between a perturbed trajectory and an unperturbed one is of the same order of magnitude as the impulsive forcing term. PB - EDP Sciences UR - http://hdl.handle.net/1963/2959 U1 - 1741 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Tensor of coherences parametrization of multiqubit density operators for entanglement characterization JF - Phys. Rev. A 69 (2004) 012311 Y1 - 2004 A1 - Claudio Altafini AB - For multiqubit densities, the tensor of coherences (or Stokes tensor) is a real parameterization obtained by the juxtaposition of the affine Bloch vectors of each qubit. While it maintains the tensorial structure of the underlying space, it highlights the pattern of correlations, both classical and quantum, between the subsystems and, due to the affine parameterization, it contains in its components all reduced densities of all orders. The main purpose of our use of this formalism is to deal with entanglement. For example, the detection of bipartite entanglement is straightforward, as it is the synthesis of densities having positive partial transposes between desired qubits. In addition, finding explicit mixtures for families of separable states becomes a feasible issue for few qubit symmetric densities (we compute it for Werner states) and, more important, it provides some insight on the possible origin of entanglement for such densities. PB - American Physical Society UR - http://hdl.handle.net/1963/2845 U1 - 1855 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Well-posedness for general 2x2 systems of conservation laws JF - Mem. Amer. Math. Soc. 169 (2004), no. 801, x+170 pp. Y1 - 2004 A1 - Fabio Ancona A1 - Andrea Marson PB - SISSA Library UR - http://hdl.handle.net/1963/1241 U1 - 2702 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - The calibration method for the Mumford-Shah functional and free-discontinuity problems JF - Calc. Var. Partial Differential Equations 16 (2003) 299-333 Y1 - 2003 A1 - Giovanni Alberti A1 - Guy Bouchitte A1 - Gianni Dal Maso AB - We present a minimality criterion for the Mumford-Shah functional, and more generally for non convex variational integrals on SBV which couple a surface and a bulk term. This method provides short and easy proofs for several minimality results. PB - Springer UR - http://hdl.handle.net/1963/3051 U1 - 1282 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Controllability properties for finite dimensional quantum Markovian master equations JF - J. Math. Phys. 44 (2003) 2357-2372 Y1 - 2003 A1 - Claudio Altafini AB - Various notions from geometric control theory are used to characterize the behavior of the Markovian master equation for N-level quantum mechanical systems driven by unitary control and to describe the structure of the sets of reachable states. It is shown that the system can be accessible but neither small-time controllable nor controllable in finite time. In particular, if the generators of quantum dynamical semigroups are unital, then the reachable sets admit easy characterizations as they monotonically grow in time. The two level case is treated in detail. PB - American Institute of Physics UR - http://hdl.handle.net/1963/2909 U1 - 1791 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Geometric motion control for a kinematically redundant robotic chain: application to a holonomic mobile manipulator JF - J. Robotic Syst. 20 (2003) 211-227 Y1 - 2003 A1 - Claudio Altafini AB - For kinematically redundant robotic manipulators, the extra degrees of freedom available allows freedom in the generation of the trajectories of the end-effector. In this paper, for this scope, we use techniques for motion control of rigid bodies on Riemannian manifolds (and Lie groups in particular) to design workspace control algorithms for the end-effector of the robotic chain and then to pull them back to joint space, all respecting the different geometric structures of the two underlying model spaces. The trajectory planner makes use of geometric splines. Examples of the different kinds of curves that are obtained via the De Casteljau algorithm in correspondence of different metric structures in SE(3) are reported. The feedback module, instead, consists of a Lyapunov based PD controller defined from a suitable notion of error distance on the Lie group. The motivating application of our work is a holonomic mobile manipulator for which simulation results are described in detail. PB - Wiley UR - http://hdl.handle.net/1963/3019 U1 - 1314 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - On the local structure of optimal trajectories in R3 JF - SIAM J. Control Optim. 42 (2003) 513-531 Y1 - 2003 A1 - Andrei A. Agrachev A1 - Mario Sigalotti AB - We analyze the structure of a control function u(t) corresponding to an optimal trajectory for the system $\\\\dot q =f(q)+u\\\\, g(q)$ in a three-dimensional manifold, near a point where some nondegeneracy conditions are satisfied. The kind of optimality which is studied includes time-optimality. The control turns out to be the concatenation of some bang and some singular arcs. Studying the index of the second variation of the switching times, the number of such arcs is bounded by four. PB - SISSA Library UR - http://hdl.handle.net/1963/1612 U1 - 2506 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Motion on submanifolds of noninvariant holonomic constraints for a kinematic control system evolving on a matrix Lie group JF - Syst. Control Lett. 50 (2003) 241-250 Y1 - 2003 A1 - Claudio Altafini A1 - Ruggero Frezza AB - For a control system on a matrix Lie group with one or more configuration constraints that are not left/right invariant, finding the combinations of (kinematic) control inputs satisfying the motion constraints is not a trivial problem. Two methods, one coordinate-dependent and the other coordinate-free are suggested. The first is based on the Wei-Norman formula; the second on the calculation of the annihilator of the coadjoint action of the constraint one-form at each point of the group manifold. The results are applied to a control system on SE(3) with a holonomic inertial constraint involving the noncommutative part in a nontrivial way. The difference in terms of compactness of the result between the two methods is considerable. PB - Elsevier UR - http://hdl.handle.net/1963/3018 U1 - 1315 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Parameter differentiation and quantum state decomposition for time varying Schrödinger equations JF - Rep. Math. Phys. 52 (2003) 381-400 Y1 - 2003 A1 - Claudio Altafini AB - For the unitary operator, solution of the Schroedinger equation corresponding to a time-varying Hamiltonian, the relation between the Magnus and the product of exponentials expansions can be expressed in terms of a system of first order differential equations in the parameters of the two expansions. A method is proposed to compute such differential equations explicitly and in a closed form. PB - Elsevier UR - http://hdl.handle.net/1963/3017 U1 - 1316 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Positive solutions to a class of quasilinear elliptic equations on R JF - Discrete Contin.Dyn.Syst. 9 (2003), no.1, 55-68 Y1 - 2003 A1 - Antonio Ambrosetti A1 - Wang Zhi-Qiang AB - We discuss the existence of positive solutions of perturbation to a class of quasilinear elliptic equations on R. PB - American Institute of Mathematical Sciences UR - http://hdl.handle.net/1963/1628 U1 - 2490 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Prescribing scalar and boundary mean curvature on the three dimensional half sphere JF - J. Geom. Anal. 13 (2003) 255-289 Y1 - 2003 A1 - Zindine Djadli A1 - Andrea Malchiodi A1 - Mohameden Ould Ahmedou AB - We consider the problem of prescribing the scalar curvature and the boundary mean curvature of the standard half three sphere, by deforming conformally its standard metric. Using blow up analysis techniques and minimax arguments, we prove some existence and compactness results. PB - Springer UR - http://hdl.handle.net/1963/3086 U1 - 1247 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Singularly perturbed elliptic equations with symmetry: existence of solutions concentrating on spheres, Part I JF - Comm. Math. Phys. 235 (2003) no.3, 427-466 Y1 - 2003 A1 - Antonio Ambrosetti A1 - Andrea Malchiodi A1 - Wei-Ming Ni PB - Springer UR - http://hdl.handle.net/1963/1633 U1 - 2485 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Some results on the boundary control of systems of conservation laws JF - SIAM J.Control Optim. 41 (2003),no.2, 607 Y1 - 2003 A1 - Alberto Bressan A1 - Fabio Ancona A1 - Giuseppe Maria Coclite PB - SISSA Library UR - http://hdl.handle.net/1963/1615 U1 - 2503 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Controllability of quantum mechanical systems by root space decomposition of su(N) JF - J.Math.Phys. 43(2002), no.5, 2051 Y1 - 2002 A1 - Claudio Altafini PB - SISSA Library UR - http://hdl.handle.net/1963/1613 U1 - 2505 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Flow Stability of Patchy Vector Fields and Robust Feedback Stabilization JF - SIAM J. Control Optim. 41 (2002) 1455-1476 Y1 - 2002 A1 - Fabio Ancona A1 - Alberto Bressan AB - The paper is concerned with patchy vector fields, a class of discontinuous, piecewise smooth vector fields that were introduced in AB to study feedback stabilization problems. We prove the stability of the corresponding solution set w.r.t. a wide class of impulsive perturbations. These results yield the robusteness of patchy feedback controls in the presence of measurement errors and external disturbances. PB - SIAM UR - http://hdl.handle.net/1963/3073 U1 - 1260 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Following a path of varying curvature as an output regulation problem JF - IEEE Trans. Automatic Control 47 (2002) 1551-1556 Y1 - 2002 A1 - Claudio Altafini AB - Given a path of nonconstant curvature, local asymptotic stability can be proven for the general n trailer whenever the curvature can be considered as the output of an exogenous dynamical system. The controllers that provide convergence to zero of the tracking error chosen for the path-following problem are composed of a prefeedback that input-output linearizes the system, plus a linear controller. PB - IEEE UR - http://hdl.handle.net/1963/3143 U1 - 1190 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - On the generation of sequential unitary gates from continuous time Schrodinger equations driven by external fields JF - Quantum Inf.Process. 1 (2002),no.3,207 Y1 - 2002 A1 - Claudio Altafini PB - SISSA Library UR - http://hdl.handle.net/1963/1614 U1 - 2504 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Geometry of Jacobi Curves I JF - J. Dynam. Control Systems 8 (2002) 93-140 Y1 - 2002 A1 - Andrei A. Agrachev A1 - Igor Zelenko AB - Jacobi curves are deep generalizations of the spaces of \\\"Jacobi fields\\\" along Riemannian geodesics. Actually, Jacobi curves are curves in the Lagrange Grassmannians. In our paper we develop differential geometry of these curves which provides basic feedback or gauge invariants for a wide class of smooth control systems and geometric structures. Two principal invariants are the generalized Ricci curvature, which is an invariant of the parametrized curve in the Lagrange Grassmannian endowing the curve with a natural projective structure, and a fundamental form, which is a fourth-order differential on the curve. The so-called rank 1 curves are studied in more detail. Jacobi curves of this class are associated with systems with scalar controls and with rank 2 vector distributions.\\nIn the forthcoming second part of the paper we will present the comparison theorems (i.e., the estimates for the conjugate points in terms of our invariants( for rank 1 curves an introduce an important class of \\\"flat curves\\\". PB - Springer UR - http://hdl.handle.net/1963/3110 U1 - 1223 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Geometry of Jacobi curves II JF - J. Dynam. Control Systems 8 (2002), no. 2, 167--215 Y1 - 2002 A1 - Andrei A. Agrachev A1 - Igor Zelenko PB - SISSA Library UR - http://hdl.handle.net/1963/1589 U1 - 2529 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Multiplicity results for the Yamabe problem on Sn JF - Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov; 99(24):15252-6 Y1 - 2002 A1 - Antonio Ambrosetti AB - We discuss some results related to the existence of multiple solutions for the Yamabe problem. PB - National Academy of Sciences UR - http://hdl.handle.net/1963/5885 U1 - 5757 U2 - Mathematics U3 - Functional Analysis and Applications U4 - -1 ER - TY - JOUR T1 - Prescribing a fourth oder conformal invariant on the standard sphere - Part I: a perturbation result JF - Commun. Contemp. Math., 2002, 4, 375 Y1 - 2002 A1 - Zindine Djadli A1 - Mohameden Ould Ahmedou A1 - Andrea Malchiodi PB - SISSA Library UR - http://hdl.handle.net/1963/1539 U1 - 2624 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Prescribing a fourth oder conformal invariant on the standard sphere - Part II: blow up analysis and applications JF - Ann. Sc. Norm. Super. Pisa Cl. Sci., 2002, 1, 387 Y1 - 2002 A1 - Zindine Djadli A1 - Andrea Malchiodi A1 - Mohameden Ould Ahmedou PB - SISSA Library UR - http://hdl.handle.net/1963/1540 U1 - 2623 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - The reachable set of a linear endogenous switching system JF - Systems Control Lett. 47 (2002) 343-353 Y1 - 2002 A1 - Claudio Altafini AB - In this work, switching systems are named endogenous when their switching pattern is controllable. Linear endogenous switching systems can be considered as a particular class of bilinear control systems. The key idea is that both types of systems are equivalent to polysystems, i.e. to systems whose flow is piecewise smooth. The reachable set of a linear endogenous switching system can be studied consequently. The main result is that, in general, it has the structure of a semigroup, even when the Lie algebra rank condition is satisfied since the logic inputs cannot reverse the direction of the flow. The adaptation of existing controllability criteria for bilinear systems is straightforward. PB - Elsevier UR - http://hdl.handle.net/1963/3142 U1 - 1191 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Solutions concentrating on spheres to symmetric singularly perturbed problems JF - C.R.Math.Acad.Sci. Paris 335 (2002),no.2,145-150 Y1 - 2002 A1 - Antonio Ambrosetti A1 - Andrea Malchiodi A1 - Wei-Ming Ni AB - We discuss some existence results concerning problems (NLS) and (N), proving the existence of radial solutions concentrating on a sphere. PB - SISSA Library UR - http://hdl.handle.net/1963/1594 U1 - 2524 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - On the Yamabe problem and the scalar curvature problems under boundary conditions JF - Math. Ann., 2002, 322, 667 Y1 - 2002 A1 - Antonio Ambrosetti A1 - Li YanYan A1 - Andrea Malchiodi PB - SISSA Library UR - http://hdl.handle.net/1963/1510 U1 - 2653 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Multiplicity results for some nonlinear Schrodinger equations with potentials JF - Arch. Ration. Mech. An., 2001, 159, 253 Y1 - 2001 A1 - Antonio Ambrosetti A1 - Andrea Malchiodi A1 - Simone Secchi PB - SISSA Library UR - http://hdl.handle.net/1963/1564 U1 - 2554 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - On the subanalyticity of Carnot-Caratheodory distances JF - Ann. I. H. Poincare - An., 2001, 18, 359 Y1 - 2001 A1 - Andrei A. Agrachev A1 - Jean-Paul Gauthier PB - SISSA Library UR - http://hdl.handle.net/1963/1483 U1 - 2680 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - On the symmetric scalar curvature problem on S\\\\sp n JF - J. Differential Equations 170 (2001) 228-245 Y1 - 2001 A1 - Antonio Ambrosetti A1 - Andrea Malchiodi AB - We discuss some existence results dealing with the scalar curvature problem on S\\\\sp n in the presence of various symmetries. PB - Elsevier UR - http://hdl.handle.net/1963/3095 U1 - 1238 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Elliptic variational problems in $ R\\\\sp N$ with critical growth JF - J. Differential Equations 168 (2000), no. 1, 10--32 Y1 - 2000 A1 - Antonio Ambrosetti A1 - Jesus Garcia Azorero A1 - Ireneo Peral PB - SISSA Library UR - http://hdl.handle.net/1963/1258 U1 - 3197 ER - TY - JOUR T1 - Existence and multiplicity results for some nonlinear elliptic equations: a survey. JF - Rend. Mat. Appl., 2000, 20, 167 Y1 - 2000 A1 - Antonio Ambrosetti A1 - Jesus Garcia Azorero A1 - Ireneo Peral PB - SISSA Library UR - http://hdl.handle.net/1963/1462 U1 - 3078 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - A note on the scalar curvature problem in the presence of symmetries JF - Ricerche Mat. 49 (2000), suppl., 169-176 Y1 - 2000 A1 - Antonio Ambrosetti A1 - Li YanYan A1 - Andrea Malchiodi PB - SISSA Library UR - http://hdl.handle.net/1963/1365 U1 - 3090 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - CHAP T1 - Principal invariants of Jacobi curves T2 - Nonlinear control in the Year 2000 / Alberto Isidori, Francoise Lamnabhi-Lagarrigue, Witold Respondek (eds.) - Springer : Berlin, 2001. - (Lecture notes in control and information sciences ; 258). - ISBN 1-85233-363-4 (v. 1). - p. 9-22. Y1 - 2000 A1 - Andrei A. Agrachev A1 - Igor Zelenko AB - Jacobi curves are far going generalizations of the spaces of \\\"Jacobi fields\\\" along Riemannian geodesics. Actually, Jacobi curves are curves in the Lagrange Grassmannians. Differential geometry of these curves provides basic feedback or gauge invariants for a wide class of smooth control systems and geometric structures. In the present paper we mainly discuss two principal invariants: the generalized Ricci curvature, which is an invariant of the parametrized curve in the Lagrange Grassmanian providing the curve with a natural projective structure, and a fundamental form, which is a 4-oder differential on the curve. JF - Nonlinear control in the Year 2000 / Alberto Isidori, Francoise Lamnabhi-Lagarrigue, Witold Respondek (eds.) - Springer : Berlin, 2001. - (Lecture notes in control and information sciences ; 258). - ISBN 1-85233-363-4 (v. 1). - p. 9-22. PB - Springer UR - http://hdl.handle.net/1963/3825 U1 - 502 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - A Remark on One-Dimensional Many-Body Problems with Point Interactions JF - Int. J. Mod. Phys. B 14 (2000) 721-727 Y1 - 2000 A1 - Sergio Albeverio A1 - Ludwik Dabrowski A1 - Shao-Ming Fei AB - The integrability of one dimensional quantum mechanical many-body problems with general contact interactions is extensively studied. It is shown that besides the pure (repulsive or attractive) $\\\\delta$-function interaction there is another singular point interactions which gives rise to a new one-parameter family of integrable quantum mechanical many-body systems. The bound states and scattering matrices are calculated for both bosonic and fermionic statistics. PB - World Scientific UR - http://hdl.handle.net/1963/3214 U1 - 1087 U2 - Mathematics U3 - Mathematical Physics ER - TY - JOUR T1 - Scalar curvature under boundary conditions JF - Cr. Acad. Sci. I-Math, 2000, 330, 1013 Y1 - 2000 A1 - Antonio Ambrosetti A1 - Li YanYan A1 - Andrea Malchiodi PB - SISSA Library UR - http://hdl.handle.net/1963/1506 U1 - 2657 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - The calibration method for the Mumford-Shah functional JF - C. R. Acad. Sci. Paris Ser. I Math. 329 (1999), no. 3, 249-254 Y1 - 1999 A1 - Giovanni Alberti A1 - Guy Bouchitte A1 - Gianni Dal Maso AB - In this Note we adapt the calibration method to functionals of Mumford-Shah type, and provide a criterion (Theorem 1) to verify that a given function is energy minimizing. Among other applications, we use this criterion to show that certain triple-junction configurations are minimizing (Example 3). PB - Elsevier UR - http://hdl.handle.net/1963/1235 U1 - 2708 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - A multiplicity result for the Yamabe problem on $S\\\\sp n$ JF - J. Funct. Anal. 168 (1999), no. 2, 529-561 Y1 - 1999 A1 - Antonio Ambrosetti A1 - Andrea Malchiodi AB - We prove a multiplicity result for the Yamabe problem on the manifold (S, g), where g is a perturbation of the standard metric g0 of Sn. Solutions are found by variational methods via an abstract perturbation result. PB - Elsevier UR - http://hdl.handle.net/1963/1264 U1 - 3191 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Nonclassical Shocks and the Cauchy Problem for Nonconvex Conservation Laws JF - J. Differential Equations 151 (1999) 345-372 Y1 - 1999 A1 - Debora Amadori A1 - Paolo Baiti A1 - Philippe G. LeFloch A1 - Benedetto Piccoli AB - The Riemann problem for a conservation law with a nonconvex (cubic) flux can be solved in a class of admissible nonclassical solutions that may violate the Oleinik entropy condition but satisfy a single entropy inequality and a kinetic relation. We use such a nonclassical Riemann solver in a front tracking algorithm, and prove that the approximate solutions remain bounded in the total variation norm. The nonclassical shocks induce an increase of the total variation and, therefore, the classical measure of total variation must be modified accordingly. We prove that the front tracking scheme converges strongly to a weak solution satisfying the entropy inequality. PB - Elsevier UR - http://hdl.handle.net/1963/3312 U1 - 1018 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Perturbation of $\Delta u+u^(N+2)/(N-2)=0$, the scalar curvature problem in $R^N$, and related topics JF - J. Funct. Anal. 165 (1999) 117-149 Y1 - 1999 A1 - Antonio Ambrosetti A1 - Jesus Garcia Azorero A1 - Ireneo Peral AB -Some nonlinear elliptic equations on $R^N$ which arise perturbing the problem with the critical Sobolev exponent are studied. In particular, some results dealing with the scalar curvature problem in $R^N$ are given.

PB - Elsevier UR - http://hdl.handle.net/1963/3255 U1 - 1446 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - On the scalar curvature problem under symmetry Y1 - 1999 A1 - Antonio Ambrosetti A1 - Andrea Malchiodi PB - SISSA Library UR - http://hdl.handle.net/1963/1287 U1 - 3168 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Branching points for a class of variational operators JF - J. Anal. Math. 76 (1998) 321-335 Y1 - 1998 A1 - Antonio Ambrosetti PB - Springer UR - http://hdl.handle.net/1963/3314 U1 - 1016 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Special functions with bounded variation and with weakly differentiable traces on the jump set JF - NoDEA Nonlinear Differential Equations Appl. 5 (1998), no. 2, 219--243 Y1 - 1998 A1 - Luigi Ambrosio A1 - Andrea Braides A1 - Adriana Garroni PB - SISSA Library UR - http://hdl.handle.net/1963/1025 U1 - 2831 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Homogeneous tangent vectors and high order necessary conditions for optimal controls JF - J. Dynam. Control Systems 3 (1997), no. 2, 205--240 Y1 - 1997 A1 - Fabio Ancona PB - SISSA Library UR - http://hdl.handle.net/1963/1015 U1 - 2841 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - THES T1 - Analysis of Singularity Structures for Quasi-Integrable Hamiltonian Systems Y1 - 1994 A1 - Simonetta Abenda KW - Hamiltonian systems PB - SISSA UR - http://hdl.handle.net/1963/5685 U1 - 5534 U2 - Mathematics U3 - Mathematical Physics U4 - -1 ER - TY - JOUR T1 - Existence of solutions for a class of non-convex differential inclusions JF - Rend.Sem.Mat.Univ. Padova, 83 (1990), 71-76 Y1 - 1990 A1 - Fabio Ancona A1 - Giovanni Colombo PB - SISSA Library UR - http://hdl.handle.net/1963/792 U1 - 2999 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - A general chain rule for distributional derivatives JF - Proc. Amer. Math. Soc. 108 (1990), no. 3, 691-702 Y1 - 1990 A1 - Luigi Ambrosio A1 - Gianni Dal Maso PB - SISSA Library UR - http://hdl.handle.net/1963/650 U1 - 3276 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Solutions with minimal period for Hamiltonian systems in a potential well. JF - Ann. Inst. H. Poincare Anal. Non Lineaire 4 (1987), no. 3, 275-296 Y1 - 1987 A1 - Antonio Ambrosetti A1 - Vittorio Coti Zelati PB - SISSA Library UR - http://hdl.handle.net/1963/466 U1 - 3437 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Symmetry breaking in Hamiltonian systems JF - J. Differential Equations 67 (1987), no. 2, 165-184 Y1 - 1987 A1 - Antonio Ambrosetti A1 - Vittorio Coti Zelati A1 - Ivar Ekeland PB - SISSA Library UR - http://hdl.handle.net/1963/409 U1 - 3558 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Dirichlet problems for demicoercive functionals JF - Nonlinear anal. 10(1986), no.6, 603-613 Y1 - 1986 A1 - Gabriele Anzellotti A1 - Giuseppe Buttazzo A1 - Gianni Dal Maso PB - SISSA Library UR - http://hdl.handle.net/1963/390 U1 - 3577 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Differential equations with multiple solutions and nonlinear functional analysis JF - Equadiff 82 (Wurzburg, 1982), 10--37, Lecture Notes in Math., 1017, Springer, Berlin, 1983 Y1 - 1982 A1 - Antonio Ambrosetti PB - SISSA Library UR - http://hdl.handle.net/1963/222 U1 - 3745 U2 - Mathematics U3 - Functional Analysis and Applications ER - TY - JOUR T1 - Recent advances in the study of the existence of periodic orbits of Hamiltonian systems JF - Advances in Hamiltonian systems (Rome, 1981), 1--22, Ann. CEREMADE, Birkhauser Boston, Boston, MA, 1983. Y1 - 1981 A1 - Antonio Ambrosetti PB - SISSA Library UR - http://hdl.handle.net/1963/159 U1 - 3808 U2 - Mathematics U3 - Functional Analysis and Applications ER -