%0 Journal Article %J International Journal Numerical Methods Biomedical Engineering %D 2012 %T Simulation-based uncertainty quantification of human arterial network hemodynamics %A Peng Chen %A Alfio Quarteroni %A Gianluigi Rozza %K uncertainty quantification, mathematical modelling of the cardiovascular system, fluid-structure interaction %X This work aims at identifying and quantifying uncertainties from various sources in human cardiovascular\r\nsystem based on stochastic simulation of a one dimensional arterial network. A general analysis of\r\ndifferent uncertainties and probability characterization with log-normal distribution of these uncertainties\r\nis introduced. Deriving from a deterministic one dimensional fluid structure interaction model, we establish\r\nthe stochastic model as a coupled hyperbolic system incorporated with parametric uncertainties to describe\r\nthe blood flow and pressure wave propagation in the arterial network. By applying a stochastic collocation\r\nmethod with sparse grid technique, we study systemically the statistics and sensitivity of the solution with\r\nrespect to many different uncertainties in a relatively complete arterial network with potential physiological\r\nand pathological implications for the first time. %B International Journal Numerical Methods Biomedical Engineering %I Wiley %G en %1 6467 %2 Mathematics %4 1 %# MAT/08 ANALISI NUMERICA %$ Submitted by Gianluigi Rozza (grozza@sissa.it) on 2013-03-07T12:33:02Z\nNo. of bitstreams: 1\nreport.pdf: 1605405 bytes, checksum: bb12cf074ce32a80567a0cde0c0861db (MD5)