%0 Journal Article %J Biomechanics and Modeling in Mechanobiology %D 2017 %T Numerical modeling of hemodynamics scenarios of patient-specific coronary artery bypass grafts %A F. Ballarin %A Elena Faggiano %A Andrea Manzoni %A Alfio Quarteroni %A Gianluigi Rozza %A Sonia Ippolito %A Roberto Scrofani %B Biomechanics and Modeling in Mechanobiology %V 16 %P 1373-1399 %G eng %U https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015065851&doi=10.1007%2fs10237-017-0893-7&partnerID=40&md5=c388f20bd5de14187bad9ed7d9affbd0 %R 10.1007/s10237-017-0893-7 %0 Report %D 2016 %T A fast virtual surgery platform for many scenarios haemodynamics of patient-specific coronary artery bypass grafts %A F. Ballarin %A Elena Faggiano %A Andrea Manzoni %A Gianluigi Rozza %A Alfio Quarteroni %A Sonia Ippolito %A Roberto Scrofani %A Carlo Antona %X A fast computational framework is devised to the study of several configurations of patient-specific coronary artery bypass grafts. This is especially useful to perform a sensitivity analysis of the haemodynamics for different flow conditions occurring in native coronary arteries and bypass grafts, the investigation of the progression of the coronary artery disease and the choice of the most appropriate surgical procedure. A complete pipeline, from the acquisition of patientspecific medical images to fast parametrized computational simulations, is proposed. Complex surgical configurations employed in the clinical practice, such as Y-grafts and sequential grafts, are studied. A virtual surgery platform based on model reduction of unsteady Navier Stokes equations for blood dynamics is proposed to carry out sensitivity analyses in a very rapid and reliable way. A specialized geometrical parametrization is employed to compare the effect of stenosis and anastomosis variation on the outcome of the surgery in several relevant cases. %I Submitted %G en %U http://urania.sissa.it/xmlui/handle/1963/35240 %1 35545 %2 Mathematics %4 1 %# MAT/08 %$ Submitted by Gianluigi Rozza (grozza@sissa.it) on 2016-10-14T23:07:40Z No. of bitstreams: 1 BMMB_SISSA_report.pdf: 16374062 bytes, checksum: 7ee82fd9d989ed91bf9cc721ae2114a0 (MD5) %0 Report %D 2015 %T Fast simulations of patient-specific haemodynamics of coronary artery bypass grafts based on a POD-Galerkin method and a vascular shape parametrization %A F. Ballarin %A Elena Faggiano %A Sonia Ippolito %A Andrea Manzoni %A Alfio Quarteroni %A Gianluigi Rozza %A Roberto Scrofani %X In this work a reduced-order computational framework for the study of haemodynamics in three-dimensional patient-specific configurations of coronary artery bypass grafts dealing with a wide range of scenarios is proposed. We combine several efficient algorithms to face at the same time both the geometrical complexity involved in the description of the vascular network and the huge computational cost entailed by time dependent patient-specific flow simulations. Medical imaging procedures allow to reconstruct patient-specific configurations from clinical data. A centerlines-based parametrization is proposed to efficiently handle geometrical variations. POD–Galerkin reduced-order models are employed to cut down large computational costs. This computational framework allows to characterize blood flows for different physical and geometrical variations relevant in the clinical practice, such as stenosis factors and anastomosis variations, in a rapid and reliable way. Several numerical results are discussed, highlighting the computational performance of the proposed framework, as well as its capability to perform sensitivity analysis studies, so far out of reach. %G en %U http://urania.sissa.it/xmlui/handle/1963/34623 %1 34824 %2 Mathematics %4 1 %# MAT/08 %$ Submitted by Gianluigi Rozza (grozza@sissa.it) on 2015-10-07T00:30:27Z No. of bitstreams: 1 REPORT.pdf: 10426315 bytes, checksum: 6e5ddf4eb4cacdc7e803c2db1a540fc9 (MD5)